Wei-Lie Xiao, Ph. D.
Professor
Email：xiaoweilie@ynu.edu.cn
Key Laboratory of Medicinal Chemistry for Natural Resource
Yunnan University
Address:Cuihubei Road 2#, Kunming, Yunnan, PR China
Education
2002-2005:Doctor of Medicinal Chemistry,major innatural productsand biological medicinefrom medicinal herbs, fromState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS),PRChina
1999-2002: Master ofPlant Physiology,Department of Agriculture, Nanjing Agricultural University,PRChina
1995-1999: Bachelor of biology,Department of Biology, HuaiBei Normal University,P RChina
Working experience
2017-Present:Professor, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming,PRChina
2012-2016:Professor,State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS),PRChina
2006-2011:Associate professor,State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS),PRChina
2005-2006: Assistant professor of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS),PRChina
2008-2010:Postdoctoral fellow, studying on the bioactive chemical constituents from herbs and their antitumor andimmunosuppressive functions inMemorial Sloan Kettering Cancer Center(MSKCC) and City University of New York (CUNY), New York, USA.
Awards:
2014: Fund for Excellent Young Scholars by National Natural Science Foundation of China
2015:Biopharmaceutical awards by Sanofi and Chinese Pharmaceutical Association
2015: Wang Kuancheng "the western scholars' outstanding contribution award" by Chinese Academy of Sciences.
2012: Young talent chemistry Prize awarded by Chinese Chemical Society.
2008: Lujiaxi young talent prize awarded by Chinese Academy of Sciences.
2007: The tenth medicinal chemistry award by Chinese Pharmaceutical Association and SERVIER.
2007: Ph.D. dissertation entitled “Study on the Chemical Constituents and Bioactivity of Four Medicinal Plants” was evaluated to be one of excellent doctor's degree dissertations of Yunnan Province.
2006: Ph.D. dissertation entitled “Study on the Chemical Constituents and Bioactivity of Four Medicinal Plants” was evaluated to be one of excellent doctor's degree dissertations of CAS.
2005: The Honghe Young Technical Prize awarded by Yunnan Province.
2005: The Prize of Distinguished Graduate Students ofChinese Academy of Sciences.
Research Interest
Dr. Wei-Lie Xiao has been engaged in natural product chemistry, biological medicines, and drug design and new drug development, based mainly on the medicinal effects of traditional Chinese herbal medicine. (1) Systematic research on the chemical constituents of medicinal plants. Up to now, 1500 compounds were isolated and characterized, including more than 400 new ones, especiallya series of novel compounds possessing 15 new carbon skeletons. (2) Some of the isolates were evaluated for their effects on anti-HIV-1, cytotoxic, and anti-neurodegenerative bioactivities. Their preliminary structure-activity relationships were also discussed. (3) One compound named as Erbenanzhi (SJP-L-5) showed potent anti-HIV-1 bioactivity with newmechanism of action, which can act as a leading compound in anti-HIV drug development.
In total, 170 papers were published. As the first author or corresponding (co-corresponding) author, the applicant has published more than 70 peer-review articles in international journals like Nat. Prod. Rep. (IF=10.178, 1 paper), Org. Lett. (IF=6.142, 9 papers), and J. Nat. Prod.( IF=3.285, 11 papers). He also presided over 20 grants includingNational Natural Science Funds for outstanding Young Scholar, the Special National Major Drug Discovery, National Natural Science Foundation projects and other types of projects.
Publications
1. Xi-Bao Zhao, De-Bing Pu, Zi-Zhao Zhao, Hui-Hui Zhu, Hong-Rui Li, Ya-Ping Shen,Xing-Jie Zhang, Rui-Han Zhang, Jian-Zhong Shen,Wei-Lie Xiao*and Wei-Lin Chen*,Teuvincenone F SuppressesLPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination,Frontiers in Pharmacology, 2017, 8, 565-580.
2. Zhong-Hua Gao，Yi-Ming Shi，Zhe Qiang，Xia Wang，Shan-Zhai Shang，Yan Yang，Bao-Wen Du，Hui-Pan Peng，Xu Ji，Hong-Lin Li*，Fei Wang*，Wei-Lie Xiao*，Plasiatine, an Unprecedented Indole-Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2.，Sci Rep，2016.4.22，6：24945~24945.
3. Yi-Ming Shi, Jie Yang, Li Xu, Xiao-Nian Li, Shan-Zhai Shang, Peng Cao*,Wei-Lie Xiao*, and Han-Dong Sun*, Structural Characterization and Antioxidative Activity of Lancifonins: Unique Nortriterpenoids from Schisandra lancifolia, Org. Lett., 2014, 16, 1370−1373.
4. Yi-Ming Shi,Xin-Bo Wang, Xiao-Nian Li, Xiao Luo, Zi-Ying Shen, Yi-Ping Wang, *;Wei-Lie Xiao*; Han-Dong Sun.* Lancolides, Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.02,11]undecane-Bridged System fromSchisandra lancifolia. Org. Lett.,2013, 15, 5068-5071.
5. Wei-Lie Xiao, Rong-Tao Li, Sheng-Xiong Huang, Jian-Xin Pu, Han-Dong Sun*, Triterpenoids from the Schisandraceae family,Nat. Prod. Rep., 2008, 25, 871-891.
6. Wei-Lie Xiao,Chun Lei, Jie Ren, Tou-Gen Liao, Jian-Xin Pu, Charles U. Pittman Jr., Yang Lu, Yong-Tang Zheng, Hua-Jie Zhu*, Han-Dong Sun*, Structure elucidation and theor etical investigation of key steps in the biogenetic pathway of schisanartane nortriterpenoids by using DFT methods,Chem. Eur. J., 2008, 14(36), 11584-11592.
