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Professor Doctor Advisor |
Office: Chemistry Building 601 |
Tel.: 86-(0)871-65033644-8899 |
Email: xdyang@ynu.edu.cn |
Address: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, No. 2 Cuihu North Road, 650091 Kunming, P.R.China |
Brief Introduction
Visiting Scholar, University of Pennsylvania (2015 - 2016)
Professor, Yunnan University (2010 - )
Associate Professor, Yunnan University (2005 - 2010)
Ph.D., Yunnan University (2005 - 2009)
M.S., Yunnan University (2000 - 2003)
Research Interests
Organic synthetic chemistry, total synthesis and medicinal chemistry
Foundation and Projects
1. National Natural Science Foundation of China, 21662043 (2017-2020), Studies on the synthesis, biological activity and mechanism of natural-product-like compounds containing the tetracyclic skeleton of Brazilin, responsible.
2. National Natural Science Foundation of China, 21462049 (2015-2016), Studies on the design, synthesis and antitumor activity of mTOR signaling pathway inhibitors based on natural product pharmacophores, responsible.
3. Natural Science Foundation of Yunnan Province, 2013FA028 (2013-2016), Studies on the design, synthesis and antitumor activity of molecular targeted drugs: Novel protein kinases inhibitors, responsible.
4. National Natural Science Foundation of China, 21062026 (2011-2013), Studies on the synthetic methods of aryl quaternary carbon-type Amaryllidaceae alkaloids, responsible.
5. National Natural Science Foundation of China, 30960460 (2010-2012), Studies on the design, synthesis and antitumor activity of natural product-like hybrid compounds between dihydrobenzofuran and imidazole, responsible.
Representative Publications
1. Xiaodong Yang*, Byeong-Seon Kim, Minyan Li, Patrick J. Walsh*, Palladium-catalyzed selective α-alkenylation of pyridylmethyl ethers with vinyl bromides, Org. Lett., 2016, 18(10), 2371-2374.
2. Xuequan Wang, Hongbin Zhang*, Xiaodong Yang*, Jingfeng Zhao, Chengxue Pan, Enantio-selective total synthesis of (+)-brazilin, (–)-brazilein and (+)-brazilide A, Chem. Commum., 2013, 49(47), 5405-5407.
3. Wen Chen, Jian Ren, Minshou Wang, Lingjing Dang, Xianfu Shen, Xiaodong Yang*, Hongbin Zhang*, Iodine mediated deprotection of N-tert-butanesulfinyl amines: a functional group compatible method, Chem. Commum., 2014, 50(47), 6259-6262.
4. Xue-Quan Wang, Lan-Xiang Liu, Yan Li, Cheng-Jun Sun, Wen Chen, Liang Li, Hong-Bin Zhang, Xiao-Dong Yang*, Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents, Eur. J. Med. Chem., 2013, 62, 111-121.
5. Lan-Xiang Liu, Xue-Quan Wang, Ju-Ming Yan, Yan Li*, Cheng-Jun Sun, Wen Chen, Bei Zhou, Hong-Bin Zhang, Xiao-Dong Yang*, Synthesis and antitumor activities of novel dibenzo[b,d]furane imidazole hybrid compounds, Eur. J. Med. Chem., 2013, 66, 423-437.
6. Wen Chen, Xiao-Dong Yang, Wen-Yun Tan, Xiang-Yang Zhang, Xia-Li Liao, Hongbin Zhang*, Total Synthesis of (‒)-Vindorosine, Angew. Chem. Int. Ed., 2017, 56(40), 12327-12331.
Patents
1. Xiao-Dong Yang, Hong-Bin Zhang, Wen Chen, Xue-Quan Wang, Li-Juan Yang, Liang Li, Dihydrofuran[b]indane-imidazolium salt compounds and their preparation method, ZL 201210237387.3, 207/05/03.
2. Xiao-Dong Yang, Hong-Bin Zhang, Xue-Quan Wang, Wen Chen, Liang Li, Jian-Ping Liu, 2-Benzyl substituted benzofuran-imidazolium salt compounds and their preparation method, ZL 201210237371.2, 2014/10/15.
