云南大学化学科学与工程学院
专业:有机化学
电子信箱: anp@ynu.edu.cn ORCID: 0000-0002-2313-5181
受教育经历及工作经历: 2008和2014 年先后获兰州大学(Lanzhou University)理学学士和博士学位,专业: 有机化学;
2011–2013年,纽约州立大学布法罗 (SUNY, Buffalo)化学系公派联合培养,方向: 化学生物学;
2014-2015,香港中文大学(CUHK)化学系 博士后,研究方向: 多环芳烃的合成;
2015-2018,纽约州立大学布法罗(SUNY, Buffalo)化学系 博士后,研究方向: 生物正交反应的开发及生物应用; 2019至今,云南大学(Yunnan University)化学科学与工程学院。
教学: 主讲有机化学,有机波谱分析等课程。
研究领域和兴趣: 有机多环芳烃的设计合成及性质研究;光诱导活性分子的激活与释放。
代表论文:
[1] Li, R.; Ma, B.; Li, M.; Wang, D.; Liu, P.; An, P.*“Multi-Heteroatom Doped Nanographenes: Enhancing Photosensitization Capacity by Forming Electron Donor-Acceptor Architecture” Chem. Sci. 2024, 15, 10.1039/D4SC02416H.
[2] Ruan, L.; Luo, W.; Zhang, H.; Liu, P.; Shi, Y.; An, P.* “Cycl[2,2,4]azine-embedded Non-alternant Nanographenes Containing Fused Antiaromatic Azepine Ring” Chem. Sci. 2024, 15, 1511–1519.
[3] Zhang, Y.; An, P.* “Construction of Substituted 2-Pyrazolines” in “Targets in Heterocyclic Synthesis Chemistry and Properties” Attanasi, O. etc, Eds. Italian Society of Chemistry, 2023, chapter 6, 116–133.
[4] Li, R.; Ma, B.; Li, S.; Lu, C.; An, P.* “Chalcogen-doped, (seco)-hexabenzocoronenebased nanographenes: synthesis, properties, and chalcogen extrusion conversion” Chem. Sci. 2023, 14, 8905–8913. (Highlighted by Synfacts 2023, 19 (12), 1203)
[5] Li, R.; Wang, D.; Li, S.; An, P.* “Construction of hexabenzocoronene-based chiral nanographenes” Beilstein J. Org. Chem. 2023, 19, 736–751. (Top cited articles of 2022–2023 in the Beilstein Journal of Organic Chemistry)
[6] Li, S.; Li, R.; Zhang, Y.-K.; Wang, S.; Ma, B.; Zhang, B.; An, P.* “BINOL-Like Atropisomeric Chiral Nanographene” Chem. Sci. 2023, 14, 3286–3292.
[7] Zhang, B.; Ruan, L.; Zhang, Y.-K.; Zhang, H.; Li, R.; An, P.* “Azepine-Embedded Seco-Hexabenzocoronene-Based Helix Nanographenes: Access to Modification of the Core by N-H Functionalization” Org. Lett. 2023, 25, 732–737.
[8] Zhang, Y.-K.; Li, M.; Ruan, L.; An, P.* “Tetrazole-ene Photoactivatable Fluorophore with Improved Brightness and Stability in Protic Solution” Chem. Commun. 2022, 58, 10404–10407.
[9] Xiao, M.; Zhang, Y.-K.; Li, R.; Li, S.; Wang, D.; An, P.* “Photoactivatable Fluorogenic Azide-Alkyne Click Reaction: A Dual-Activation Fluorescent Probe” Chem. Asian J 2022, 17, e202200634. (Cover paper, Top Downloaded Article 2023)
[10] Lewandowski, T. M.; An, P.; Ramil, C.; Fang, M.; Lin, Q.* “Dual Fluorescent Labeling of GLP-1R in Live Cells via Enzymatic Tagging and Bioorthogonal Chemistry” RSC Chem. Biol. 2022, 3, 702–706.
[11] Ma, B.; Xiao, M.; Liu, P.; An, P.* “Synthesis of Azepine- or Azocine-Embedded Hexabenzocoronene-Based Nanographenes” Synlett, 2022, 33, 409–414.
[12] Li, R.; Ma, B.; He, R.; Zhang, B.; Zhang, Y.; Feng, S. An, P.* “Azepine- or Oxepine-embedded Double Saddle-Helix Nanographenes” Chem. Asian J. 2022, 17, e202101365. (Highlighted by WileyChem)
[13] An, P.*; Li, R.; Ma, B.; He, R.; Zhang, Y.; Xiao, M.; Zhang, B. “Azepine- or Azocine-Embedded Hexabenzocoronene Derivatives as Nitrogen-Doped Saddle or Saddle-Helix Nanographenes” Angew. Chem. Int. Ed. 2021, 60, 24478–24483. (Highlighted by Wiley Chem & X-mol, Synlett, 2022, 33, 409)
[14] An, P.; Lewandowski, T. M.; Erbay, T. G.; Liu, P.; Lin, Q.* “Sterically Shielded, Stabilized Nitrile imine for Rapid Bioorthogonal Protein Labelling in Live Cells” J. Am. Chem. Soc. 2018, 140, 4860.
[15] An, P.; Wu,H.-Y.; Lewandowski, T. M.; Lin, Q.* “Hydrophilic azaspiroalkenes as robust bioorthogonal reporters” Chem. Commun. 2018, 54, 14005.
[16] An, P.; Lin, Q.* “Sterically Shielded Tetrazoles for Fluorogenic Photoclick Reaction: Tuning Cycloaddition Rate and Product Fluorescence” Org. Biomol. Chem. 2018, 16, 5241.
[17] An, P.; Lewandowski, T. M.; Lin, Q*. “Design and Synthesis of a BODIPY-Tetrazole Based "Off-On" In-Cell Fluorescent Reporter of Hydrogen Peroxide” ChemBioChem. 2018, 19. 1326.
[18] Ramil, C.; Dong, M.; An, P.; Lewandowski, T. M.; Yu, Z.; Miller, L. J. *; Lin, Q. * “Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells” J. Am. Chem. Soc. 2017, 139, 13376.
[19] An, P.; Chow, H.-F.*, Kuck, D.* “A Polycyclic Aromatic Hydrocarbon Bearing an all-cis-Tetrabenzo[5.5.5.5] fenestrane (Fenestrindane) Core Merged with Two Hexa-peri-hexabenzocoronene Units” Synlett, 2016, 27, 1255. (Highlighted by Synfacts 2016, 12 (07), 0681)
[20] Ramil, C.; An, P; Yu, Z.; Lin, Q.* “Sequence-Specific 2-Cyanobenzothiazole Ligation” J. Am. Chem. Soc. 2016, 138, 5499.
[21] Shi, Z.*; An, P.; Wen, W.; Xing, Z.; Cao, X.*; Zhang, H. “Dendron-Enhanced Emission from 1,4-Bis[2,2-bis(4-alkoxyphenyl)vinyl]benzene Derivatives” Asian J. Org. Chem. 2016, 5, 786.
[22] An, P.; Xu, N.; Zhang, H.; Cao, X.*; Shi, Z.*; Wen, W. “Facile Preparation of α-Cyano-α,ω-Diaryloligovinylenes: A New Class of Color-Tunable Solid Emitters” Chem. Asian J. 2015, 10, 1959.
[23] An, P.; Yu, Z.; Lin, Q. * “Design and Synthesis of Laser-Activatable Tetrazoles for Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction” Org. Lett. 2013, 15, 5496.
[24] An, P.; Yu, Z.; Lin, Q.* “Design of Oligothiophene-Based Tetrazoles for Laser-Inducible Photoclick Chemistry in Living Cells” Chem. Commun. 2013, 49, 9920.
[25] Yu, Z.; Ohulchanskyy, T.; An, P.; Prasad, P. N.; Lin, Q. “Fluorogenic, Two-Photon Triggered Photoclick Chemistry in Live Mammalian Cells” J. Am. Chem. Soc. 2013, 135, 16766.
[26] An, P.; Shi, Z. F.*; Dou, W.; Cao, X. P.*; Zhang, H. L. “Synthesis of 1,4-Bis [2,2-bis(4-alkoxyphenyl) vinyl] benzenes and Side Chain Modulation of Their Solid-State Emission” Org. Lett. 2010, 12, 4364. (Highlighted by ACS as a "Noteworthy Chemistry" item. October 18, 2010)
科研项目和奖励:
1. Thieme Chemistry Journals Award (2023)
2. 云南省高层次人才青年项目,2021-2025。(负责)
3. 国家自然科学基金地区基金(22061046),2021.1-2024.12。(负责)
4. 国家自然科学基金青年基金(21901226),2020.1-2022.12。(负责)