云南大学化学科学与工程学院
蔡乐（博士，教授，博士生导师）
专业：分析化学，微生物与生化药学，有机化学
团队：分离分析团队
电话：0871-65033719
电子信箱：caile@ynu.edu.cn
受教育经历及工作经历：
2000、2003和2006年先后获华西医科大学理学学士、四川大学理学硕士和博士学位；
2007年，云南大学化学科学与工程学院·药学院工作；
2016年，评为教授，并担任云南大学化学科学与工程学院•药学院副院长。
教 学：
主讲《生药学》和《物质结构鉴定与表征》。
研究领域和兴趣：
微生物发酵改性中药材，微生物转化反应以及天然药物化学研究。
论文、专著：
学术论文
[1] Wang Jiapeng, Yu Jing, Shu Yan, Shi Yaxian, Luo Ping, Cai Le*, Ding Zhongtao*. Peniroquesines A−C: Sesterterpenoids Possessing a 5−6−5−6−5-Fused Pentacyclic Ring System from Penicillium roqueforti YJ-14. Organic Letters, 20(18): 5853-5856, 2018
[2] Wang Jiapeng, Shu Yan, Liu Shixi , Hu Juntao , Sun Chengtong , Zhou Hao, Gan Dong, Cai Xueyun , Pu Wei, Cai Le*, Ding Zhongtao*. Expanstines A-D: four unusual isoprenoid epoxycyclohexenones generated by Penicillium expansum YJ-15 fermentation and photopromotion. Organic Chemistry Frontiers, 6: 3839-3846, 2019
[3] Wang Jiapeng, Shu Yan, Hu Juntao, Liu Rui, Cai Xueyun, Sun Chengtong, Gan Dong, Zhou Dijiao, Mei Ruifeng, Ding Hao, Zhang Xiaoran, Cai Le*, Ding Zhongtao*. Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14. Organic Chemistry Frontiers, 7: 1463-1468, 2020
[4] Xing Yun, Cai Le*, Yin Tianpeng, Chen Yang, Yu Jing, Wang Yarong, Ding Zhongtao*. Improving the antioxidant activity and enriching salvianolic acids by the fermentation of Salvia miltiorrhizae with Geomyces luteus. Journal of Zhejiang University. Science. B, 17: 391-398, 2016
[5] Cai Le, Dong Jianwei, Zhao Lixing, Zhou Hao, Xing Yun, Li Ying, Li Zhenjie, Duan Weihe, Li Xuejiao, Ding Zhongtao*. An improved water-soluble/stereospecific biotransformation of aporphine alkaloids in Stephania epigaea to 4R-hydroxyaporphine alkaloids by Clonostachys rogersoniana. Process Biochemistry, 91: 933-940, 2016
[6] Yang Minghui, Fang Yunshan, Cai Le*, Li Ying, Dong Jianwei, Yin Tianpeng, Huang Caili, Ding Zhongtao. A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum. Natural product research, 30: 1617-1622, 2016
[7] Dong Jianwei, Cai Le*, Fang Yunshan, Duan Weihe. Li Zhenjie, Ding Zhongtao*. Simultaneous, Simple and Rapid Determination of Five Bioactive Free Anthraquinones in Radix et Rhizoma Rhei by Quantitative 1H NMR. Journal of the Brazilian Chemical Society, 27: 2120-2126, 2016
[8] 马迎聪, 俞静, 王家鹏, 蔡乐*, 丁中涛. 韭菜根的化学成分研究. 中国药学杂志, 51: 972-975, 2016
[9] Li Xuejiao, Dong Jianwei, Cai Le*, Mei Ruifeng, Ding Zhongtao. Improving the acetylcholinesterase inhibitory effect of Illigera henryi by solid-state fermentation with Clonostachys rogersoniana. Journal of Bioscience and Bioengineering, 124(5): 493-497, 2017
[10] Yin Tianpen, Shu Yan, Zhou Hao, Cai Le*, Ding Zhongtao*.Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum. Fitoterapia, 135: 1-4, 2019
[11] Dong Jianwei, Cai Le*, Li Xuejiao, Wang Jiapeng, Mei Ruifeng, Ding Zhongtao*. Monoterpene esters and aporphine alkaloids from Illigera aromatica with inhibitory effects against cholinesterase and NO production in LPS-stimulated RAW264.7 macrophages. Archives of pharmacal research, 40(12): 1394-1402, 2017
[12] Dong Jianwei, Cai Le*, Li Xuejiao, Mei Ruifeng, Wang Jiapeng, Luo ping, Shu Yan, Ding Zhongtao*. Fermentation of Illigera aromatica with Clonostachys rogersoniana producing novel cytotoxic menthane-type monoterpenoid dimers. RSC Advances, 7: 38956-38964, 2017
[13] Fang Yunshan, Liu Shixi, Ma Yingcong, Dong Jianwei, Cai Le*, Ding Zhongtao. A new phenylpropanoid glucoside and a chain compound from the roots of Allium tuberosum. Natural product research, 31: 70-76, 2017
[14] Li Xuejiao, Dong Jianwei, Cai Le*, Wang Jiapeng, Yu Nenxiang, Ding Zhongtao*. Illigerones A and B, two new long-chain secobutanolides from Illigera henryi W. W. Sm. Phytochemistry Letters, 19: 181-186, 2017
[15] Yin Tianpeng, Xing Yun, Cai Le*, Yu Jing, Luo Ping, Ding Zhongtao*. A new polyketide glycoside from the rhizospheric Clonostachys rogersoniana associated with Panax notoginseng. Journal of Asian Natural Products Research, 19(12): 1258-1263, 2017
[16] Yu Jing, Yin Tianpeng, Wang Jiapeng, Mei Ruifeng, Cai Le*, Ding Zhongtao*. A new C20-diterpenoid alkaloid from the lateral roots of Aconitum carmichaeli. Natural product research, 31: 228-232, 2017
[17] Dong Jianwei, Cai Le*, Li Xuejiao, Shu Yan, Wang Jiapeng, Ding Zhongtao*. A novel sesquiterpene derivative with a seven-membered B ring from Illigera aromatic. Natural Product Research, 32: 2589-2595, 2018
[18] Dong Jianwei, Cai Le*, Li Xuejiao, Mei Ruifeng, Luo Ping; Ding Zhongtao*. Improving antioxidant activity of Ophioglossum thermale Kom. by fermentation with Talaromyces purpurogenus M18-11. Journal of the Brazilian Chemical Society, 29: 1927-1933, 2018
[19] Fang Yunshan, Yang Minghui, Cai Le*, Wang Jiapeng, Yin Tianpeng, Yu Jing, Ding Zhongtao*. New phenylpropanoids from Bulbophyllum retusiusculum. Archives of Pharmacal Research, 41: 1074-1081, 2018
[20] Shu Yan, Yin Tianpeng, Wang Jiapeng, Gan Dong, Zhang Qinyan, Cai Le*, Ding Zhongtao*. Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum. Chinese Journal of Natural Medicines, 16: 866-870, 2018
[21] Yin Tianpeng, Shu Yan, Mei Ruifeng, Wang Jiapeng, Cai Le*, Ding Zhongtao*. Diterpenoid alkaloids from Aconitum taronense and their chemotaxonomic significance. Biochemical Systematics and Ecology, 81: 99-101, 2018
[22] Yin Tianpeng, Hu Xiaofang, Mei Ruifeng, Shu Yan, Gan Dong, Cai Le*, Ding Zhongtao*. Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener. Phytochemistry Letters, 25: 152-155, 2018
[23] Mei Ruifeng, Shi Yaxian, Duan Weihe, Ding Hao, Zhang Xiaoran, Cai Le*, Ding Zhongtao*. Biotransformation of α-terpineol by Alternaria alternata. RSC Adv., 10: 6491-6496, 2020
[24] Yin Tianpeng , Zhou Hao, Cai Le*, Ding Zhongtao*. Non-alkaloidal constituents from the genus Aconitum: a review. RSC Advances, 9: 10184-10194, 2019
[25] 董建伟, 李雪娇, 蔡乐*, 缪应纯. 以去氢弯孢霉素NMR结构解析讲授本科生波谱分析课程. 大学化学, 35 (3): 113-119, 2020
专著及教材
[1] 蔡乐主编，高等学校化学实验室安全基础，化学工业出版社，2018年，北京。
科研项目、成果和专利：
1．苏铁蕨活性成分研究以及brainicine B 及其异构体的合成研究，国家自然科学基金（21002084，青年基金），2011.01-2013.12。（主持）
2．四种滇产乌头的发酵改性及发酵乌头的镇痛抗炎活性物质基础研究，国家自然科学基金（81460648，地区基金），2015.01-2018.12。（主持）
3．Clonostachys rogersoniana发酵改性香青藤的化学机制及抗肿瘤活性物质基础研究，国家自然科学基金（81660719，地区基金），2017.01-2020.12。（主持）
4．尖孢镰刀菌对滇产土牛膝的发酵改性研究，国家自然科学基金（81960760，地区基金），2020.01-2023.12。（主持）
5．棠梨花和短瓣兰的抗肿瘤和抗氧化活性成分研究，云南省自然科学基金（2010CD017，面上项目），2011.01-2013.12。（主持）
6．云南省中青年学术和技术带头人后备人才，云南省科技厅（2018HB036），2018.01-2022.12。
7．蔡乐，丁中涛，王家鹏，舒燕. “一种倍半萜环己烯酮类化合物及其制备方法和应用”，中国发明专利，专利号：ZL201910323259.2。
8．蔡乐，丁中涛，邢赟，尹田鹏. “一种通过固体发酵微生物Clonostachys rogersoniana产生抗生素TMC-154的方法”，中国发明专利，专利号：ZL201610976539.X。
9．蔡乐，罗伟，丁中涛，董建伟．“通过罗杰斯无性穗霉发酵处理香青藤制备化合物的方法及应用”，中国发明专利，专利号：ZL201710603948.X。
10．丁中涛，蔡乐，李莹．“通过尖孢镰刀菌发酵改性小百部富集红苋甾酮的新方法”，中国发明专利，专利号：ZL201510284205.1。
11．丁中涛，蔡乐，董建伟．“一种通过固体发酵镰孢菌Fusarium sp.产生新抗菌剂sambacide的方法”，中国发明专利，专利号：ZL201610421717.2。
12．丁中涛，蔡乐，王家鹏，俞静．“一种抗炎活性化合物peniroquesine A及其制备方法和应用”，中国发明专利，专利号：ZL201711259540.1。
奖励、荣誉和学术兼职：
云南省高等学校药学类（含临床药学、制药工程等）专业教学指导委员会副主任委员。
