Zhao Li-Xing, Ph. D.
Professor
Key Laboratory of Medicinal Chemistry for Natural Resource
Yunnan University
No.2 North Cuihu Road, Kunming, P. R. China
Email: lixingzhao@ynu.edu.cn
Education
1997.8 – 2000.6, Ph. D., Microbiology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang
1994.9 – 1997.7, M. Sc., Botany, Chinese Academy of Forestry, Beijing
1990.9 – 1994.7, Bachelor of Agriculture, Department of Forestry, Anhui Agricultural University, Hefei
Working experience
2018.11 – Present, Professor, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University
2012.11 – 2018.10, Associate Professor, Yunnan Institute of Microbiology, Yunnan University
2007.05 – 2012.10, Assistant Professor, Yunnan Institute of Microbiology, Yunnan University,
2007.08 – 2008.07, Visiting Scholar, School of Pharmacy, University of Wisconsin-Madison
2000.06 – 2007.05, Engineer, Center of Research and Development, KPC Pharmaceuticals, Inc, Kunming
Research Interests
Computer-aided drug design, bioinformatics and chemical informatics: exploring the bioactivity of natural products, discovery of lead compound via structure modification.
Structure dynamics of nucleosome and enzymes related to epigenetic modifications, and the modulating mechanism of small molecules.
i. Microbial resource and bioactive-screening Pharmaceuticals from microorganisms play key roles in clinical and agronomy. It is an important way to solve the drug resistance and develop new pharmaceutical from the microorganism harbored in different niches.
ii. Research on microbial natural drugs Microorganisms have being the most important source of antimicrobial and antitumor pharmaceuticals in clinical, and are widely used in agronomy and animal husbandry. Natural products or lead compounds from diverse niches is a reservoir for research and development of microbial drugs.
Publications
1. Peng, G.; Xiong, D.-S.; Li, L.-C.; Hu, J.-Y.; Bao, S.; Chen, Y.-W.; Li, Y.-Q.; Xu, L.-H.; Miao, C.-P.; Zhao, L.-X.* Amycolatopsis panacis sp. nov., isolated from Panax notoginseng rhizospheric soil. International Journal of Systematic and Evolutionary Microbiology, 2019, 69:567-571
2. Luo, N.; Yang, Y.-B.; Yang, X.-Q.; Miao, C.-P.; Li, Y.-Q.; Xu, L.-H.; Ding, Z.-T.; Zhao, L.-X.* The streptazolin- and obscurolide-type metabolites from soil-derived Streptomyce alboniger YIM20533 and the mechanism of influence of γ-butyrolactone on the growth of Streptomyces by their non-enzymatic reaction biosynthesis. RSC Advances, 2018, 8:35042-35049
3. Wang, Q.; Yang, Y.-B.; Yang, X.-Q.; Miao, C.-P.; Li, Y.-Q.; Liu, S.-X.; Luo, N.; Ding, Z.-T.; Zhao, L.-X.* Lovastatin analogues and other metabolites from soil-derived Aspergillus terreus YIM PH30711. Phytochemistry, 2018,145(1):146-152
4. Zheng, Y.-K.; Miao, C.-P.; Chen, H.-H.; Huang, F.-F.; Xia, Y.-M.; Chen, Y.-W.; Zhao L.-X.*. Endophytic fungi harbored in Panax notoginseng - diversity and potential as biological control agents against host plant pathogens of root-rot disease. Journal of Ginseng Research, 2017, 41:353-360
5. Chen, J.-L.; Sun, S.-Z.; Miao, C.-P.; Wu, K.; Chen Y.-W.; Xu, L.-H.; Guan, H.-L; Zhao L.-X.* Endophytic Trichoderma gamsii YIM PH30019: a promising biocontrol agent with hyperosmolar, mycoparasitism, and antagonistic activities of induced volatile organic compounds on root-rot pathogenic fungi of Panax notoginseng. Journal of Ginseng Research. 2016, 40:315-324
6. Miao, C.-P.; Mi, Q.-L.; Qiao, X.-G.; Zheng, Y.-K.; Chen, Y.-W.; Xu, L.-H.; Guan H.-L.; Zhao L.-X.* Rhizospheric fungi of Panax notoginseng: diversity and antagonism to host phytopathogens. Journal of Ginseng Research. 2016, 40:127-134
7. Fan, Z.-Y.; Miao, C.-P.; Qiao, X.-G.; Zheng, Y.-K.; Chen, H.-H.; Chen, Y.-W.; Xu, L.-H.; Zhao L.-X.;* Guan, H.-L. Diversity, distribution, and antagonistic activities of rhizobacteria of Panax notoginseng. Journal of Ginseng Research. 2016, 40:97-104
8. Cao, P.; Yang, J.; Miao, C.-P.; Yan, Y.J.; Ma, Y.-T.; Li, X.-N.; Zhao L.-X.;* Huang, S.-X. New duclauxamide from Penicillium manginii YIM PH30375 and structure revision of the duclauxin family. Organic Letters. 2015, 17:1146-1149
9. Liu, K.; Yang, Y.-B.; Miao, C.-P.; Zheng, Y.-K.; Chen, J.-L.; Chen, Y.-W.; Xu, L.-H.; Guan, H.-L.; Ding, Z.-T.; Zhao L.-X.* Koningiopsins A-H, polyketides with synergistic antifungal activities from the endophytic fungus Trichoderma koningiopsis. Planta Medica. 2016, 82:371-376
10. Xiong, Z.-J.; Miao, C.-P.; Zheng, Y.-K.; Liu, K.; Li, W.-J.; Liu, W.-H.; Xu, L.-H.; Zhao L.-X.* Stackebrandtia endophytica sp. nov., an actinobacterium isolated from Tripterygium wilfordii. International Journal of Systematic and Evolutionary Microbiology. 2015, 65:1709-1713
11. Zhao, L.-X.; Xu, L.-H.; Jiang, C.-L. Methods for the study of endophytic microorganisms from traditional Chinese medicine plants. Methods in Enzymology. 2012, 517:3-21
12. Zhao, L.-X.; Huang, S.-X.; Tang, S.-K.; Jiang, C.-L.; Duan, Y.; Beutler, J.-A.; Henrich, C.-J.; McMahon, J.-B., Schmid, T.; Blees, J.-S.; Colburn, N.-H.; Rajski, S.-R.; Shen, B. Actinopolysporins A-C and Tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Journal of Natural Products. 2011, 74:1990-1995
