Zhang Ruihan, Ph. D.
Assistant research fellow
Key Laboratory of Medicinal Chemistry for Natural Resource
Yunnan University
No.2 North Cuihu Road, Kunming, P. R. China
Email:zhangruihan@ynu.edu.cn
Education
2013- 2016: Ph. D, Biology (Biophysics), German Cancer Research Center/University of Heidelberg, Heidelberg Germany (funded by DFG Excellence Initiative)
2011- 2013: M. Sc, Drug Design , Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences
2006- 2010: B. Eng, Pharmaceutical Engineering , Zhejiang University, Department of Chemical and Biological Engineering, Hangzhou, Zhejiang
Working experience
2017-Present: Assistant research fellow, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming, China
Apr.-June.2015: Visiting scholar at Purdue University, West Lafayette, Indiana, USA
Research Interest
Computer-aided drug design, bioinformatics and chemical informatics: exploring the bioactivity of natural products, discovery of lead compound via structure modification.
Structure dynamics of nucleosome and enzymes related to epigenetic modifications, and the modulating mechanism of small molecules.
Publications
1. Gao, J. B.#; Yang, S. J.#; Yan, Z. R.; Zhang, X. J.; Pu, D. B.; Wang, L. X.; Li, X. L.;Zhang, R. H.*; Xiao, W. L.*, Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. Journal of Natural Products 2018, 81, (4), 998-1006.
2. Zhang, R. H.; Liu, Z. K.; Yang, D. S.; Zhang, X. J.; Sun, H. D.; Xiao, W. L.*, Phytochemistry and pharmacology of the genus Leonurus: The herb to benefit the mothers and more. Phytochemistry 2018, 147, 167-183.
3. Zhang, R.; Erler, J.; Langowski, J., Histone Acetylation Regulates Chromatin.Accessibility: Role of H4K16 in Inter-nucleosome Interaction.Biophysical Journal2017, 112 (3), 450-459.
4. Lehmann, K.;Zhang, R. (co-first); Schwarz, N.; Gansen, A.; Mucke, N.; Langowski, J.; Toth, K., Effects of charge-modifying mutations in histone H2A alpha3-domain on nucleosome stability assessed by
5. Erler, J.;Zhang, R.; Petridis, L.; Cheng, X.; Smith, J.; Langowski, J., The role of histone tails in the nucleosome: A computational study.Biophysical Journal2014,107
6. Zhang, R.; Li, X.; Liang, Z.; Zhu, K.; Lu, J.; Kong, X.; Ouyang, S.; Li, L.; Zheng, Y. G.; Luo, C., Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.Plos One2013,8(8).
7. Zhang, R.; Lu, J.; Kong, X.; Jin, L.; Luo, C., Targeting epigenetics in nervous system disease.Cns & Neurological Disorders-Drug Targets2013,12(1), 126-141.
8. Zhang, J.; Liu, H.; Zhu, K.; Gong, S.; Dramsi, S.; Wang Y.; Li, J.; Chen, F.;Zhang, R.; Zhou, L.; Lan, L.; Jiang, H.; Schneewind, O.; Luo, C.; and Yang, CG., Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase , Proc. Natl. Acad. Sci. USA,2014, 111(37), 13517–13522
