Xing-Jie Zhang, Ph.D.
Assistant Research Fellow
Key Laboratory of Medicinal Chemistry for Natural Resource
Yunnan University
No.2 North Cuihu Road, Kunming, P. R. China
Email: zhangxj@ynu.edu.cn
Education
2003-2007 B.S., Yunnan University
2007-2014 Ph.D. candidate, the Chinese Academy of Sciences, Kunming Institute of zoology
2014-2016 Engineer, Yunnan Bai Yao Group Innovation and R&D Center/ Yunnan Institute of Materia Medica
2016-present Assistant Research Fellow, Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education
Research Interests
Anti-inflammatory, immunoregulatory, anti-cancer biological mechanisms of natural products and synthetic compounds.
Representative Publications
1.Zhang X J, Lu L H, Wang R R, Wang Y P, Luo R H, Lai C C, Yang L M, He Y P, Zheng Y T.2013. DB-02, a C-6-cyclohexylmethyl substituted pyrimidinone HIV-1 reverse transcriptase inhibitor with nanomolar activity, displays an improved sensitivity against K103N or Y181C thanS-DABOs.PLoS ONE, 8(11): e81489
2.Zhang X J, Yang G Y, Wang R R, Pu J X, Sun H D, Xiao W L, Zheng Y T.2010. 7,8-secolignans fromSchisandra wilsonianaand their anti-HIV-1 activities.Chemistry and Biodiversity, 7: 2692-2701.
3. Guo D L#,Zhang X J#, Wang R R, Zhou Y, Li Z, Xu J Y, Chen K X, Zheng Y T, Liu H.2012. Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity.Bioorganic and Medicinal Chemistry Letters, 22: 7114-7118.
4. Bai R,Zhang X J, Li Y L, Liu J P, Zhang H B, Xiao W L, Pu J X, Sun H D, Zheng Y T and Liu L X. SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry.BMC Microbiology,2015, 15:274.
5. Wang L X, Fang Y D, Zhang R H, Ren FC,Zhang X J, Wang F, and Xiao W L. Hispanane-type Diterpenoid and Secoiridoid Glucosides from Viburnum cylindricum. Chemistry & biodiversity,2017(ePub ahead).
6. Wang R R, Yang Q H, Luo R H, Peng Y M, Dai S X,Zhang X J, et al.2014. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PloS one, 9(8): e105617. (IF=3.234)
7. Liu G N, Luo R H, Zhou Y,Zhang X J, et al.2016. Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives [J]. Molecules, 21(9): 1198 (IF=2.465)
8. Rashed K,Zhang X J, Luo M T and Zheng Y T.2012. Anti-HIV-1 activity of phenolic compounds isolated fromDiospyros lotusfruits.Phytopharmacology, 3: 199-207
9. Huang S Z,Zhang X J, Li X Y, Jiang H Z, Ma Q Y, Wang P C, Liu Y Q, Hu J M, Zheng Y T, Zhou J, Zhao Y X.2012. Phenols with anti-HIV activity fromDaphne acutiloba.Planta Medica, 78: 182-185.
10. Huang S Z,Zhang X J, Li X Y, Kong L M, Jiang H Z, Ma Q Y, Liu Y Q, Hu J M, Zheng Y T, Li Y, Zhou J, Zhao Y X.2012. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.Phytochemistry, 75: 99-107.
