黄荣, Rong HUANG, researcher, PhD
High-level young talents in Shaanxi Province
Xi 'an Jiaotong University "Top Young Talents"
Email: huangrong(at)xjtu.edu.cn, Please manually replace (at) with @
Home - 黄 荣
Main research interests:
1. The molecular mechanism and physiological function of CiVDS, a new theory of synaptic transmission;
2. Study on the pathogenesis and new clinical targets of chronic pain;
3. Support students to explore interesting and potential good directions;
Understanding the working mechanism of the brain is one of the greatest challenges for mankind and science. Calcium activity and vesicular secretion activity in the nervous system are one of the most basic life activities of the brain and neurons. They are the basis for maintaining normal physiological functions of the brain. Its regulation mechanism has always been this field's most basic and important key scientific issue. The applicant has made a series of breakthroughs in the triggering and regulation mechanism of nerve secretion, the coupling and balance mechanism of exocytosis and endocytosis, spontaneous calcium activity, and chronic pain by combining electrophysiological, electrochemical, high-resolution TIRFM imaging, pharmacology, and other tools: ① Revealing the new regulation mechanism of "calcium-independent secretion-CiVDS", proving that CiVDS is widely distributed in the sympathetic system and regulates heart function, and clarifying that CiVDS participates in central synaptic transmission, which is the most basic for the secretion field. ② The "throttle and brake" mechanism of two-way regulation of endocytosis was revealed for the first time, and a new mechanism of "coupling and balance of exocytosis and endocytosis" was discovered. ③ Based on the above neural activities triggered by external stimuli, the regulatory function of spontaneous calcium activity in the pathological process of chronic pain and other related diseases was further revealed. All the original discoveries mentioned above were made in China, which is a major original innovation and key contribution to the field of neurosecretion in China in recent years.
2014.09-2020.01 北京大学，前沿交叉学科研究院，整合生命科学，博士
2010.09-2014.07 四川大学，轻工科学与工程学院，轻工生物技术，学士
2023.01-2028.12 西安交通大学，生命学院，研究员，博士生导师
2020.07-2022.12 北京大学，未来技术学院，博士后，助理研究员，师从海内外著名神经生物学家周专教授
8. 国家自然科学基金，32400650，2025.01-2027.12，在研，主持；
7. 陕西省项目，2023SYJ09，2024.01-2029.12，在研，主持；
6. 陕西省面上项目，2024JC-YBMS-141，2024.01-2025.12，在研，主持；
5. 西安交通大学“青年拔尖人才”计划，2023.01-2028.12，在研，主持；
4. 北京大学“博雅博士后”项目，2020.07-2022.06，结题，主持；
3. 中国博士后科学基金，第14批特别资助(站中)，2021T140014，2021.01-2022.12，结题，主持；
2. 中国博士后科学基金，第68批面上资助，2020M680211，2021.01-2022.12，结题，主持；
1. 国家自然科学基金，重点项目，31930061，2020.01-2024.12，结题，参与。
2024 中国神经学会突触可塑性分会委员
2023 陕西省高层次青年人才
2023 Biophysics Reports期刊青年编委
2023 西安市“地区优秀人才”
2022 西安交通大学“青年拔尖人才”
2020 北京大学“博雅博士后”
2020 北京市优秀毕业生
2020 北京大学优秀毕业生
2014 四川省优秀大学毕业生
2014 四川大学优秀毕业生干部
2013 国家奖学金
2011 国家奖学金
2015 中国生物物理学会“Best Poster Award”
2018 北京大学三好学生
2017 北京大学五四奖学金
2011 四川大学优秀团员干部
2010 四川大学党校优秀学员
代表性论文(通讯*，一作#)：
Zhuoyu Zhang, Rong Huang*. Stronger stimulus triggers synaptic transmission faster through earlier started action potential. Cell Communication and Signaling. 2024, DOI: 10.1186/s12964-024-01483-3 (期刊论文，IF：8.4)
Yang Chen, Shaoqin Hu, Xuanang Wu, Zhenli Xie, Yuan Wang, Bianbian Wang, Xiaopeng Li, Yingmei Pei, Yuhao Gu, Kai Huang, Jingxiao Huo, Anqi Wei, Cheng Bi, Zhe Lu, Qian Song, Huadong Xu, Xinjiang Kang, Shuli Shao, Jiangang Long, Jiankang Liu, Zhuan Zhou, Rong Huang*, Zuying Chai*, and Changhe Wang*. Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis. PNAS. 2022, DOI: 10.1073/pnas.2111051119 (期刊论文，IF：12.8)
Yuan Wang#, Rong Huang#, Zuying Chai#, Changhe Wang#, Xingyu Du, Yuqi Hang, Yongxin Xu, Jie Li, Xiaohan Jiang, Xi Wu, Zhongjun Qiao, Yinglin Li, Bing Liu, Xianying Zhang, Peng Cao, Feipeng Zhu, Zhuan Zhou. Ca2+-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Reports. 2022, DOI: 10.15252/embr.202154507 (期刊论文，IF：9.1)
Rong Huang#, Yuan Wang#, Jie Li#, Xiaohan Jiang#, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang, Zuying Chai, and Zhuan Zhou. Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system. PNAS. 2019, DOI: 10.1073/pnas.1902444116 (期刊论文，IF：12.8)
Zuying Chai#, Changhe Wang#, Rong Huang#, Yuan Wang#, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, Zhuan Zhou. CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons. Neuron. 2017, DOI: 10.1016/j.neuron.2017.10.028 (期刊论文，IF：18.7)
Highlighted in Nature Reviews Neuroscience (Natasha Bray, A discrete form of secretion, 2017, 19(1):6. doi: 10.1038/nrn.2017.162).
Recommended by the Faculty of 1000 (F1000Prime recommendations by Ronald W Holz, Yang Yang and William Colmers).
其它论文：
Quanfeng Zhang#, Bing Liu#, Yinglin Li#, Lili Yin, Muhammad Younus, Xiaohan Jiang, Zhaohan Lin, Xiaoxuan Sun, Rong Huang, Bin Liu, Qihui Wu, Feipeng Zhu, and Zhuan Zhou. Regulating quantal size of neurotransmitter release through a GPCR voltage sensor. PNAS. 2020, DOI: 10.1073/pnas.2005274117 (期刊论文，IF：12.8)
Changhe Wang#, Xinjiang Kang#, Li Zhou#, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, Zhuan Zhou. Synaptotagmin-11 is a critical mediator of parkin-linked Parkinson’s disease. Nature Communications. 2017, DOI: 10.1038/s41467-017-02593-y (期刊论文，IF：17.7)
Highlighted in Movement Disorders (Moghaddam HS and Arabi MH, Synaptotagmin-11 is a novel hotspot in the pathogenesis of parkin-linked Parkinson’s disease: new implications for clinical targeting, 2018, 33(4):582).
Yeshi Wang#, Qihui Wu#, Meiqin Hu, Bin Liu, Zuying Chai, Rong Huang, Yuan Wang, Zhou Li, Huadong Xu, Changhe Wang, and Zhuan Zhou. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Science Signaling. 2017, DOI: 10.1126/scisignal.aal1683 (期刊论文，IF：9.5)
Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p).
Changhe Wang#, Yeshi Wang#, Meiqin Hu#, Zuying Chai, Qihui Wu, Rong Huang, Weiping Han, ClaireXi Zhang, Zhuan Zhou. Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports. 2016, DOI: 10.15252/embr.201540689 (期刊论文，IF：9.1)
Shujiang Shang#, Feipeng Zhu#, Bin Liu#, Zuying Chai, Qihui Wu, Meiqin Hu, Yuan Wang, Rong Huang, Xiaoyu Zhang, Xi Wu, Lei Sun, Yeshi Wang, Li Wang, Huadong Xu, Sasa Teng, Bing Liu, Lianghong Zheng, Chen Zhang, Fukang Zhang, Xinghua Feng, Desheng Zhu, Changhe Wang, Tao Liu, Michael Xi Zhu, Zhuan Zhou. Intracellular TRPA1 Mediates Ca2+ Release from lysosomes in dorsal root ganglion neurons. Journal of Cell Biology. 2016, DOI: 10.1083/jcb.201603081 (期刊论文，IF：8.1)
Highlighted in Journal of Cell Biology (Mingxue Gu and Haoxing Xu, A painful TR(i)P to lysosomes, 2016, 215(3):309-312).
