基本信息

 

 

王昌河 教授

Ph.D. 博士生导师 国家级人才

神经科学研究中心主任

生物系主任

陕西省科技创新团队带头人

陕西省杰出青年基金获得者

陕西省百人计划青年学者

西安交通大学师德标兵

西安交通大学青年拔尖人才

贝时璋青年生物物理学家奖

陕西青年科技奖

教育部自然科学一等奖（第3完成人）

脑科学与类脑智能科创新青年30人

 

 

 

 

      王昌河，教授，博士生导师，国家级人才，陕西省科技创新团队带头人、陕西省杰出青年基金获得者，西安交通大学师德标兵，西安交通大学青年拔尖人才，荣获第六届贝时璋青年生物物理学家奖、第十三届陕西省青年科技奖、教育部自然科学一等奖（第三）、脑科学与类脑智能科创青年30人、北京大学优秀博士后、北大-清华生命科学联合中心优秀博士后等；目前担任生物系主任、神经科学研究中心主任、中国生物物理学会理事、中国生物物理学会神经生物物理分会副主任兼秘书长、中国神经科学学会突触可塑性分会副主任、中国神经科学学会离子通道与受体分会委员、中国生理学会衰老与健康专业委员会委员、中国生物物理学会科普委员会委员、中国老年学学会衰老与抗衰老科学委员会委员、CAMPUS Asia Project学术委员会委员、中国神经修复学会精准治疗分会委员、科普中国特聘专家、Neuroscience Bulletin青年编委。

联系方式

西安交通大学

生命科学与技术学院

E-mail: changhewang@xjtu.edu.cn

           changhecool@163.com

通讯地址：陕西省西安市碑林区咸宁西路28号西安交通大学生命科学与技术学院, 西安，710049

站点计数器

科研背景

 

2003年于四川大学吴玉章学院(原创新班学院)四川大学-华盛顿大学联合创新班获理学学士学位；2006年于四川大学生命学院获动物学硕士学位；2012年于北京大学分子医学研究所获生理学博士学位；2012-2015年于北京大学分子医学研究所、北大-清华生命科学联合中心从事博士后研究。2016年获得北京大学优秀博士后、同年入选西安交通大学‘青年拔尖人才’，2017年入选陕西省‘百人计划’青年学者，2018年获教育部自然科学一等奖（第三完成人）、同年获陕西省杰出青年基金，2019年获中国生物物理学会最高荣誉贝时璋青年生物物理学家奖、同年入选教育部青年长江学者，2020年获陕西省青年科技奖、入选陕西省高层次人才引进计划（青年项目），2021年获批陕西省科技创新团队，2023年获脑科学与类脑智能科创新青年30人，2024年获西安交通大学师德标兵。目前担任生命学院神经科学研究中心主任，神经生物学学科带头人，生物系主任，生命学院学术委员会委员、学位委员会委员、教学委员会委员、教材委员会委员，担任中国生物物理学会理事、中国生物物理学会神经生物物理分会副主任委员兼秘书长、中国神经科学学会突触可塑性分会副主任、陕西省脑疾病分子医学专业委员会副主任委员、中国神经科学学会离子通道与受体分会委员、中国细胞生物学学会神经细胞生物学分会委员、中国生理学会衰老与健康专业委员会委员、中国老年学学会衰老与抗衰老科学委员会委员、中国神经修复学会精准治疗分会委员、CAMPUS Asia Project学术委员会委员、中国生物物理学会科普委员会委员、中国生理学会青委会委员、教育部科学技术奖评审专家、教育部长江学者奖励计划通讯评审专家、科普中国特聘专家、陕西省细胞生物学会理事、Neuroscience Bulletin青年编委。

 

主要研究方向包括：1）神经分泌与突触传递的调控机制，2）情绪与行为决策的环路机制，3）多巴胺系统相关疾病（帕金森病、精神分裂症、成瘾、痛等）的病理机制。实验室拥有电生理（膜片钳记录、sniffer patch、UV-flash、钙成像）、电化学（微碳纤电极细胞/脑片/in vivo水平的实时记录、微透析-HPLC分析）、生物成像（confocal、TIRF、two photon、电镜等）、光遗传、行为学及分子生化等特色技术手段，在神经递质量子分泌调控机制、胞吐-胞吞偶联平衡机制及帕金森病、成瘾、慢性痛等相关神经疾病的病理机制方面取得一系列突破性研究进展。在国际权威学术期刊发表研究（SCI）论文52篇，累计影响因子~517；其中，以通讯作者在Science (2025), Nat Neurosci (2024), Adv Sci (2024), Nat Commun (2024, 2023, 2014), PNAS (in press, 2022, 2019), J Cell Biol (2020, 2016)等期刊发表高水平论文22篇，申请/授权国际/国家发明专利15项，研究成果得到Nature, Science, Nat Rev Neurosci, Nat Neurosci, J Cell Biol, Mov Disord, F1000 Prime等亮点评述和特别推荐。同时，受邀担任国内神经领域经典教科书《神经科学》第四版中《神经递质的分泌与调控》和《多巴胺》两个章节的主编人、承担《中国大百科全书》第三版中《胞吐》、《胞吞》和《胞饮》三个条目的撰写、担任国家十三五规划图书《人体线粒体功能障碍与重大疾病》（获国家出版基金、陕西省出版基金）第五卷《线粒体与神经退行性疾病》主编。

教育经历

2008-2012    北京大学    分子医学研究所，生理学博士（指导老师: 周专教授、张曦教授）     

2003-2006    四川大学   生命科学学院，动物学硕士（指导老师: 郭聪教授）
2000-2003    四川大学    吴玉章学院（四川大学－华盛顿大学联合创新班），生物科学学士

工作经历

 

2018-             西安交通大学生命科学与技术学院，教授，博士生导师

2016-2017     西安交通大学生命科学与技术学院，研究员，博士生导师

2012-2015    北京大学分子医学研究所/北大-清华生命科学联合中心，博士后（合作导师: 周专教授）
2006-2014    齐齐哈尔大学生命科学与农林学院，助教/讲师/副教授

 

荣誉与获奖

2024.07    西安交通大学师德标兵

2024.07    西安交通大学教学成果二等奖（第五完成人）

2023.12    脑科学与类脑智能科创新青年30人

2021.08    苏州工业园区第十五届第一批“金鸡湖科技领军人才”

2021.07    第五届昆山创新创业大赛一等奖

2021.07    2021年“金鸡湖创业大赛”华东赛区三等奖

2021.03    陕西省科技创新团队

2020.12    第十三届陕西省青年科技奖

2020.09    陕西省高层次人才引进计划（青年项目）

2019.07    青年长江学者

2019.07    第六届贝时璋青年生物物理学家奖

2019.01    陕西省杰出青年基金获得者

2018.02    量子化神经递质囊泡的分泌机理，教育部自然科学一等奖(第三完成人)

2017.03    陕西省‘百人计划’青年学者，陕西省人民政府

2016.01    西安交通大学青年拔尖人才, 西安交通大学

2016.01    北京大学优秀博士后, 北京大学.

2014.10    北大－清华生命科学联合中心优秀博士后基金, 北京大学.

2014.08    生物膜与膜生物工程国家重点实验室学术报告二等奖, 北京大学.

2008-2012  北京大学学业奖学金二等奖, 北京大学.

2009-2010  李彦宏奖学金, 北京大学.                                                                                

2004-2005  光华一等奖学金, 四川大学.

2003-2004  优秀硕士二等奖, 四川大学.

2002-2003  四川大学优秀本科毕业论文三等奖, 四川大学.

2001-2002  四川大学本科跳级资格, 四川大学.

2001-2002  ‘四川大学-华盛顿大学杰出青年’ 荣誉称号, 四川大学.

2000-2001  四川大学台禅祖寺奖助学金, 四川大学.

学术任职

分会主任 

2023 -   中国神经科学学会突触可塑性分会副主任

2019 -   陕西省脑疾病分子医学专业委员会副主任

2018 -   中国生物物理学会神经生物物理分会副主任委员、秘书长

 

学会理事

2021-             中国生物物理学会理事

2018-             陕西省细胞生物学会理事

2012-2017    黑龙江省蛋白质组学会理事

2011-2015    黑龙江省微生物学会理事

 

学会委员 

2023 -   中国细胞生物学会神经细胞分会委员

2023 -   中国生理学会青年委员会委员

2020 -   中国神经科学学会突触可塑性分会委员

2020 -   中国神经科学学会离子通道与受体分会委员

2020 -   中国生理学会衰老与健康专业委员会委员

2019 -   中国神经修复学会精准治疗分会委员

2017 -   中国老年学与老年医学学会抗衰老分会委员

2017 -   CAMPUS Asia Project学术委员会委员

2017-    中国生物物理学会科普委员会委员

2018 -   科普中国特聘专家

 

 
期刊编辑
Neuroscience Bulletin青年编辑委会委员
 

 

近期代表论文

代表性论文 (# Equal Contribution)

  1. Anqi Wei, Anran Zhao, Chaowen Zheng, Nan Dong, Xu Cheng, Xueting Duan, Shuaijie Zhong, Xiaoying Liu, Jie Jian, Yuhao Qin, Yuxin Yang, Yuhao Gu, Bianbian Wang, Niki Gooya, Jingxiao Huo, Jingyu Yao, Weiwei Li, Kai Huang, Haiyao Liu, Fenghan Mao, Ruolin Wang, Mingjie Shao, Botao Wang, Yichi Zhang, Yang Chen, Qian Song, Rong Huang, Qiumin Qu, Chunxiang Zhang*, Xinjiang Kang*, Huadong Xu*, and Changhe Wang*, Sexually dimorphic dopaminergic circuits determine sex preference. Science, 2025, 387, eadq7001 (IF: 44.7, *Corresponding authors)

Free-access reprint link: https://www.science.org/stoken/author-tokens/ST-2350/full 

Recommended by Science (Circuits for switching social preference)

Highlighted in Science (Bitna Joo1 and Kay Tye, Stress drives a switch in sex preference, Science, 2025, 387(6730), 138-9).

  1. Zhuoyu Zhang, Jingyu Yao, Jingxiao Huo, Ruolin Wang, Xueting Duan, Yang Chen, Huadong Xu, Changhe Wang*, Zuying Chai*, Rong Huang*. Action potential- independent spontaneous microdomain Ca2+ transients-mediated continuous neurotransmission regulates hyperalgesia. PNAS,  in press (IF: 9.4, *Corresponding authors)
  2. Qian Song, Anqi Wei, Huadong Xu, Yuhao Gu, Yong Jiang, Nan Dong, Chaowen Zheng, Qinglong Wang, Min Gao, Suhua Sun, Xueting Duan, Yang Chen, Bianbian Wang, Jingxiao Huo, Jingyu Yao, Hao Wu, Hua Li, Xuanang Wu, Zexin Jing, Xiaoying Liu, Yuxin Yang, Shaoqin Hu, Anran Zhao, Hongyan Wang, Xu Cheng, Yuhao Qin, Qiumin Qu, Tao Chen, Zhuan Zhou, Zuying Chai*, Xinjiang Kang*, Feng Wei*, and Changhe Wang*. An ACC-VTA-ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences. Nat Neurosci, 2024, 27(2): 272-285. (IF: 25, *Corresponding authors)

Featured article in Nature Neuroscience. Web of Science高被引论文，被中国生物物理学会推荐2024年度“中国生命科学十大进展”

  1. Xiaoxuan Sun, Lili Yin, Zhongjun Qiao, Muhammad Younus, Guoqing Chen, Xi Wu, Jie Li, Xinjiang Kang, Huadong Xu, Li Zhou, Yinglin Li, Min Gao, Xingyu Du, Yuqi Hang, Zhaohan Lin, Liyuan Sun, Qinglong Wang, Ruiying Jiao, Lun Wang, Meiqin Hu, Yuan Wang, Rong Huang, Yiman Li, Qihui Wu, Shujiang Shang, Shu Guo, Qian Lei, Haifeng Shu, Lianghong Zheng, Shirong Wang, Feipeng Zhu, Panli Zuo*, Bing Liu*, Changhe Wang*, Quanfeng Zhang*, Zhuan Zhou*. Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo. Adv Sci, 2024, 2412229 (IF: 15.1, *Corresponding authors)
  2. Yang Chen, Yuhao Gu, Bianbian Wang, Anqi Wei, Nan Dong, Yong Jiang, Xiaoying Liu.Li Zhu, Feng Zhu, Tao Tan, Zexin Jing, Fenghan Mao,Yichi Zhang,Jingyu Yao, YuxinYang, Hongyan Wang, Hao Wu, HuaLi, Chaowen Zheng, Xueting Duan, Jingxiao HuoXuanang Wu, Shaoqin Hu, Anran Zhao, Ziyang Li, Xu Cheng, Yuhao Qin, Qian Song.Shuqin Zhan, Qiumin Qu, Fanglin Guan, Huadong Xu*, Xinjiang Kang*, and Changhe Wang*. Synaptotagomin-11 deficiency in dopamine neurons mediates schizophrenia-like behaviors in mice. Nat Commun, 2024, 15:10571 (IF: 14.7, *Corresponding authors)
  3. Hao Wu, Yicong Dong, Qiang Meng, Jingyi Jiang, Bojian Gao, Yutao Ren, Yong Liu, Huanfa Li, Changhe Wang*, Hua Zhang*. Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy. Neurobiol Dis. 2025,204:106767 (IF: 7.05, *Corresponding authors)
  4. Shaoqin Hu, Zhenli Xie, Bianbian Wang, Zexin Jing, Ying Hao, Jingyu Yao, Xuanang Wu, Jingxiao Huo, Anqi Wei, Yuhao Qin, Nan Dong, Chaowen Zheng, Qian Song, Jiangang Long, Yang Chen, Xinjiang Kang*, Changhe Wang*, and Huadong Xu*, STED Imaging of Vesicular Endocytosis in the Synapse. Neurosci Bull, 2024 doi: 10.1007/s12264-024-01254-7 (IF: 5.27, *Corresponding authors)
  5. Lun Wang, Min Gao, Qinglong Wang, Liyuan Sun, Muhammad Younus, Sixing Ma, Can Liu, Li Shi, Yang Lu, Bo Zhou, Suhua Sun, Guoqing Chen, Jie Li, Quanfeng Zhang, Feipeng Zhu*, Changhe Wang*, and Zhuan Zhou*. Cocaine induces locomotor sensitization through a dopamine- dependent VTA-mPFC-FrA cortico-cortical pathway in male mice. Nat Commun, 2023, 14(1):1568. (IF: 17.69, *Corresponding authors)
  6. Yang Chen, Shaoqin Hu, Xuanang Wu, Zhenli Xie, Yuan Wang, Bianbian Wang, Xiaopeng Li, Yingmei Pei, Yuhao Gu, Kai Huang, Jingxiao Huo, Anqi Wei, Cheng Bi, Zhe Lu, Qian Song, Huadong Xu, Xinjiang Kang, Shuli Shao, Jiangang Long, Jiankang Liu, Zhuan Zhou, Rong Huang*, Zuying Chai*, and Changhe Wang*. Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis. Proc Natl Acad Sci USA, 2022, 119(20): e2111051119. (IF: 12.78, *Corresponding authors)
  7. Yuan Wang#, Rong Huang#, Zuying Chai#, Changhe Wang#, Xingyu Du, Yuqi Hang, Yongxin Xu, Jie Li, Xiaohan Jiang, Xi Wu, Zhongjun Qiao, Yinglin Li, Bing Liu, Xianying Zhang, Peng Cao, Feipeng Zhu and Zhuan Zhou*. Ca2+-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Rep, 2022, e54507. DOI 10.15252/embr.202154507. (IF: 9.07, #Co-first authors)
  8. Huadong Xu#, Xu Cheng#, Qian Song, Yuxin Yang, Changhe Wang*, Xinjiang Kang*. Induced dopaminergic neurons for Parkinsons’s disease therapy: targeting the striatum or midbran/substantia nigra pars compacta? Neurosci Bull. 2022, 38(7): 820-824. DOI：10.1007/s12264-022-00829-6. (IF: 5.27, *Corresponding authors) .
  9. Xuanang Wu#, Shaoqin Hu#, Xinjiang Kang*, and Changhe Wang*. Synaptotagmins: beyond presynaptic neurotransmitter release. Neuroscientist. 2020, 26(1):9-15. (IF: 7.52, *Corresponding authors) .
  10. Bing Liu#, Yiman Li#, Shujiang Shang, Changhe Wang*, Michael X. Zhu* and Zhuan Zhou*. Reply to: TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium. J Cell Biol. 2020, 219(6):e202004017. (IF: 10.54, *Corresponding authors) .
  11. Rong Huang#, Yuan Wang#, Jie Li#, Xiaohan Jiang#, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang*, Zuying Chai*, Zhuan Zhou*. Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian synpathetic nervous system. Proc Natl Acad Sci U S A, 2019, 116(40):20201-20209. (IF: 9.58, *Corresponding authors).
  12. Mingzhu Huang#, Bianbian Wang#, Xiaopeng Li#, Chongluo Fu*, Changhe Wang*, and Xinjiang Kang*. ɑ-Synuclein: a multifunctional player in exocytosis, endocytosis, and vesicle recycling. Front Neurosci. 2019, 13:28. doi: 10.3389/fnins.2019.00028. (IF: 3.71, *Corresponding authors)
  13. Qian Song#, Mingzhu Huang#, Bianbian Wang#, Xinjiang Kang, Wang Changhe*. Bidirectional regulation of Ca2+ in exo-endocytosis coupling. Sci China Life Sci. 2018, 61(12):1583-1585. (IF: 3.58, *Corresponding author)
  14. Changhe Wang#, Xinjiang Kang#, Li Zhou#, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, and Zhuan Zhou*. Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology. Nat Commun. 2018, 9:81. doi:10.1038/s41467-017-02593-y. (IF: 12.35, #Co-first authors).

Highlighted in Movement Disorders (Moghaddam HS and Arabi MH, Synaptotagmin-11 is a novel hotspot in the pathogenesis of parkin-linked Parkinson’s disease: new implications for clinical targeting, 2018, 33(4):582).

  1. Zuying Chai#, Changhe Wang#, Rong Huang#, Yuan Wang#, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, and Zhuan Zhou*. CaV2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons. Neuron. 2017, 96(6):1317-26. (IF: 14.32, #Co-first authors).

Highlighted in Nature Reviews Neuroscience (Natasha Bray, A discrete form of secretion, 2017, 19(1):6. doi: 10.1038/nrn.2017.162).

Recommended by the Faculty of 1000 (F1000Prime recommendations by Ronald W Holz, F1000Prime recommendations by Yang Yang, and F1000Prime recommendations by William Colmers).

  1. Yeshi Wang#, Qihui Wu#, Meiqin Hu, Bin Liu, Zuying Chai, Rong Huang, Yuan Wang, Zhou Li, Xu Huadong, Changhe Wang*, and Zhuan Zhou*. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Sci Signal. 2017, 10(484), eaal1683. (IF: 7.36, *Corresponding authors) (Front Cover).

Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p).

  1. Zhenli Xie, Jiangang Long, Jiankang Liu, Zuying Chai*, Xinjiang Kang*, Changhe Wang*.  Molecular mechanisms for the coupling of endocytosis to exocytosis in neurons. Front Mol Neurosci. 2017, 10:47. doi:10.3389/fnmol.2017.00047. (IF: 5.2, *Corresponding authors)
  2. Zuying Chai, Yang Chen, Changhe Wang*. β-arrestin-1: bridging GPCRs to active TRP channels. Channels. 2017, 11(5):357-9. (IF: 2.54, *Corresponding author)
  3. Changhe Wang#, Yeshi Wang#, Meiqin Hu#, Zuying Chai, Qihui Wu, Rong Huang, Weiping Han, Claire Xi Zhang*, Zhuan Zhou. Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep. 2016, 17(1):47-63. (IF: 9.06, #Co-first authors) (Front Cover)
  4. Shujiang Shang#, Feipeng Zhu#, Bin Liu#, Zuying Chai, Qihui Wu, Meiqin Hu, Yuan Wang, Rong Huang, Xiaoyu Zhang, Xi Wu, Lei Sun, Yeshi Wang, Li Wang, Huadong Xu, Sasa Teng, Bing Liu, Lianghong Zheng, Chen Zhang, Fukang Zhang, Xinghua Feng, Desheng Zhu, Changhe Wang*, Tao Liu*, Michael Xi Zhu*, Zhuan Zhou*. Intracellular TRPA1 Mediates Ca2+ Release from lysosomes in dorsal root ganglion neurons. J Cell Biol. 2016, 215(3):369-381. (IF: 8.72, * Corresponding authors)

Highlighted in Journal of Cell Biology (Mingxue Gu and Haoxing Xu, A painful TR(i)P to lysosomes, 2016, 215(3):309-312).

  1. Haiqiang Dou#, Changhe Wang#, Xi Wu, Lijun Yao, Xiaoyu Zhang, Sasa Teng, Huadong Xu, Bin Liu, Qihui Wu, Quanfeng Zhang, Meiqin Hu, Yeshi Wang, Li Wang, Yi Wu, Shujiang Shang, Xinjiang Kang, Lianghong Zheng, Jin Zhang, Matthieu Raoux, Jochen Lang, Qing Li, Jing Su, Xiao Yu*, Liangyi Chen*, Zhuan Zhou*. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 2015, 58(2):324-33. (IF: 6.67, #Co-first authors)

‘Up Front’ article in Diabetologia.

  1. Huadong Xu, Panli Zuo, Shirong Wang, Li Zhou, Xiaoxuan Sun, Meiqin Hu, Bin Liu, Qihui Wu, Haiqiang Dou, Bing Liu, Feipeng Zhu, Sasa Teng, Xiaoyu Zhang, Li Wang, Qing Li, Mu Jin, Xinjiang Kang*, Wei Xiong, Changhe Wang*, Zhuan Zhou*. Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst. 2015, 140:3840-3845. (IF: 4.11, *Corresponding authors)
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  6. Ling Zhong, Zhenzhen Yan, Dexiang Jiang, Kuo-Chan Weng, Yue Ouyang, Hangyu Zhang, Xiaoqing Lin, Chenxin Xiao, Huaiyu Yang, Jing Yao, Xinjiang Kang, Changhe Wang, Chen Huang, Bing Shen, Sookja Kim Chung, Zhi-Hong Jiang, Wandi Zhu, Erwin Neher, Jonathan R Silva, Panpan Hou. Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants. Circ Res. 2024,135(7):722-738. (IF: 16.5)
  7. Feipeng Zhu, Lina Liu, Jie Li, Bing Liu, Qinglong Wang, Ruiying Jiao, Yongxin Xu, Lun Wang, Suhua Sun, Xiaoxuan Sun, Muhammad Younus, Changhe Wang, Tomas Hokfelt, Bo Zhang, Howard Gu, Zhi-Qing David Xu, Zhuan Zhou. Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Rep, 2022, 40(7): 111199. doi: 10.1016/j.celrep.2022.111199. (IF: 10.00)
  8. Zhaohan Lin, Yinglin Li, Yuqi Hang, Changhe Wang, Bing Liu, Jie Li, Lili Yin, Xiaohan Jiang, Xingyu Du, Zhongjun Qiao, Feipeng Zhu, Zhe Zhang, Quanfeng Zhang, Zhuan Zhou. Tuning the Size of Large Dense‐Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid-Liquid Phase Separation. Adv Sci, 2022, 27: e2202263. doi: 10.1002/advs.202202263. (IF: 17.52)
  9. Shengpeng Wang, Bianbian Wang, Yue Shi, Tanja Möller, Rebekka I Stegmeyer, Boris Strilic, Ting Li, Zuyi Yuan, Changhe Wang, Nina Wettschureck, Dietmar Vestweber, Stefan Offermanns. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood, 2022, 140(3):171-183. (IF: 25.48)
  10. Hui Wang, Ze Yuan, Bianbian Wang, Bochuan Li, Huizhen Lv, Jinlong He, Yaqian Huang, Zhen Cui, Qiannan Ma, Ting Li, Yi Fu, Xiaoli Tan, Yangping Liu, Shengpeng Wang, Changhe Wang, Wei Kong*, Yi Zhu. Cartilage Oligomeric Matrix Protein, a Novel PIEZO1 Regulator that Controls Blood Pressure. Hypertension, 2022, 79(3):549-561. (IF: 10.19)
  11. Xiaozhe Zhang, Na Li, Jun Zhang, Yanshen Zhang, Xiaoli Yang, Yifan Luo, Bobo Zhang, Zhixue Xu, Zhenhua Zhu, Xiuyan Yang, Yuan Yan, Biao Lin, Shen Wang, Caichao Ye, Yan Ding, Mingliang Lou, Qingcui Wu, Zhanfeng Hou, Keren Zhang, Ziming Liang, Anqi Wei, Bianbian Wang, Changhe Wang, Nan Jiang, Wenqing Zhang, Guozhi Xiao, Cong Ma, Yan Ren, Xiangbing Qi, Weiping Han, Chao Wang and Feng Rao. 5-IP7: a GPCR messenger mediating muscarinic control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab. 2021, 3(10):1400-1414. (IF: 13.51).
  12. ShengPeng Wang*, Shuang Cao, Malika Arhatte, Dahui Li, Yue Shi, Sabrina Kurz, Jiong Hu, Lei Wang, Jingchen Shao, Ann Atzberger, Zheng Wang, Changhe Wang, Weijin Zang, Ingrid Fleming, Nina Wettschureck, Eric Honoré, Stefan Offermanns*. Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 2020, 11(1):2303. doi: 10.1038/s41467-020-16026-w. (IF: 14.92)
  13. Mingli Li#, Huadong Xu#, Guoqing Chen, Suhua Sun, Qinglong Wang, Bing Liu, Xi Wu, Li Zhou, Zuying Chai, Xiaoxuan Sun, Yang Lu, Muhammad Younus, Lianghong Zheng, Feipeng Zhu, Hongbo Jia, Xiaowei Chen, Changhe Wang and Zhuan Zhou*. Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease. Brain. 2019, 142(10):3099-3115. (IF: 11.81).
  14. Quanfeng Zhang#, Bin Liu#, Qihui Wu#, Bing Liu, Yinglin Li, Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang,1 Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, and Zhuan Zhou*. Differential co-release of two neurotransmitters from a vesicle fusion pore in mammalian adrenal chromaffin cells. Neuron. 2019, 102(1):173-83. (IF: 14.42).
  15. Qihui Wu#, Quanfeng Zhang#, Bin Liu, Yinglin Li, Xi Wu, Shuting Kuo, Lianghong Zheng, Changhe Wang, Feipeng Zhu and Zhuan Zhou*. Dynamin-1 restrains vesicular release to a sub-quantal mode in mammalian adrenal chromaffin cells. J Neurosci. 2019, 39(2):199-211. (IF: 6.07).
  16. Zhuan Zhou*, Zuying Chai, Changhe Wang. From structure to function: unveiling the structure of the Nav channel–toxin complex. Natl Sci Rev. 2019, 6(5): 859-860 (IF: 16.69).
  17. Yingfei Xiong#, Sasa Teng#, Lianghong Zheng, Suhua Sun, Jie Li, Ning Guo, Mingli Li, Li Wang, Feipeng Zhu, Changhe Wang, Zhiren Rao*, Zhuan Zhou*. Stretch-induced Ca2+ independent ATP release in hippocampal astrocytes. J Physiol. 2018, 596: 1931-47. (IF: 4.74)
  18. Chen Hou#, Yongyao Wang, Jiankang Liu, Changhe Wang, Jiangang Long*. Neurodegenerative disease related proteins have negative effects on SNARE-mediated membrane fusion in pathological confirmation. Front Mol Neurosci. 2017, 10:66. DOI: 10.3389/fnmol.2017.00066. (IF: 5.2)
  19. Linling He#, Quanfeng Zhang#, Liecheng Wang, Jingxia Dai, Changhe Wang, Lianghong Zheng*, Zhuan Zhou*. Muscarinic inhibition of nicotinic transmission in neurons and adrenal chromaffin cells. Philos Trans R Soc Lond B Biol Sci. 2015, 370:20140188. DOI: 10.1098/rstb.2014.0188. (IF: 7.06)
  20. Xinjinag Kang#, Huadong Xu#, Sasa Teng#, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Qian Lei, Jing Lv, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Weilin Li*, Kang Zhang*, Zhuan Zhou*. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci USA. 2014, 111(44):15804-9. (IF: 9.81)

Weekly press tipsheet in PNAS.

  1. Li Wang#, Xiaoyu Zhang#, Huadong Xu, Li Zhou, Ruiying Jiao, Wei Liu, Feipeng Zhu, Xinjiang Kang, Bin Liu, Sasa Teng, Qihui Wu, Mingli Li, Haiqiang Dou, Panli Zuo, Changhe Wang, Shirong Wang and Zhuan Zhou*. (2014) Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. J Physiol. 592:3559-76. (IF: 5.04)
  2. Lina Liu, Feipeng Zhu, Meiying Song, Xinjiang Kang, Shujiang Shang, Xiaoyu Zhang, Huadong Xu, Sasa Teng, Bin Liu, Shuting Kuo, Wei Liu, Mingli Li, Li Zhou, Ruiying Jiao, Changhe Wang, Shirong Wang, Hui Yang, Bo Zhang, Zhuan Zhou*, Zhiqing Xu*. Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons. J Mol Neurosci. 2014, 53(3):345-51. (IF: 2.76)
  3. Shuting Kuo#, Qihui Wu#, Bin Liu#, Zhenli Xie, Xi Wu, Shujiang Shang, Xiaoyu Zhang, Xinjiang Kang, Lina Liu, Feipeng Zhu, Yeshi Wang, Meiqin Hu, Huadong Xu, Li Zhou, Bin Liu, Zuying Chai, Quanfeng Zhang, Wei Liu, Sasa Teng, Changhe Wang, Ning Guo, Haiqiang Dou, Panli Zuo, Lianghong Zheng, Claire Xi Zhang, Desheng Zhu, Li Wang, Shirong Wang*, Zhuan Zhou*.  Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese university. J Mol Neurosci. 2014, 53(3):487-92. (IF: 2.76)
  4. Lianghong Zheng, Changhe Wang, Shujiang Shang, Xiaoyu Zhang, Yeshi Wang, Qihui Wu, Meiqin Hu, Zuying Chai, Xi Wu, Hui Zheng, Chen Zhang, Liecheng Wang, Wei Xiong, Zhuan Zhou*.  Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells. Am J Physiol Cell Physiol. 2013, 305(7):C751-60. (IF: 3.67)
  5. Tao Liu, Shujiang Shang, Bin Liu, Changhe Wang, Yeshi Wang, Wei Xiong, Lianghong Zheng, Claire Xi Zhang*, Zhuan Zhou*. Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. J Physiol. 2011, 589 (14): 3507-15. (IF: 4.72)
  6. Tao Liu#, Lei Sun#, Yingfei Xiong, Shujiang Shang, Ning Guo, Sasa Teng, Yeshi Wang, Bin Liu, Changhe Wang, Li Wang, Lianghong Zheng, Claire Xi Zhang*, Weiping Han*, Zhuan Zhou*. Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci. 2011, 31(29): 10593-601. (IF: 7.12)