职    称

 教授

科研方向

 纳米农药负载体系设计及构筑

招生专业

 植物保护（农药学）

联系方式

 0538-8242611；libeixing@126.com

个人简介

李北兴，男，汉族，山东省济宁市金乡县人，群众，农学博士。现为山东省高等学校“青创团队计划”团队带头人，入选中国科协青年人才托举工程，全国农药学科优秀中青年科技工作者。担任《山东农业大学学报（自然科学版）》编委，《植物医学》、《农药学学报》等期刊青年编委。兼任中国植物保护学会青年工作委员会委员。近年来，主持国家自然科学基金、国家重点研发计划子课题、中国博士后科学基金、中央引导地方科技发展专项等项目12项。H指数21，他引1200余次，以通讯/第一作者在Advanced Functional Materials、ACS Nano、Chemical Engineering Journal等期刊发表论文29篇，其中SCI收录23篇，7篇IF>8，4篇IF>10，单篇最高被引87次。主编农业农村部规划教材1部。授权专利8件，1项转化落地。研制系列载药产品，推广应用800余万亩，以首位获山东省高等学校科学技术二等奖等奖励。主持入选中国高等教育博览会“校企合作 双百计划”典型案例。

教学背景及工作经历

2024.01-至      今：山东农业大学植物保护学院\教授

2021.11-2023.12：山东农业大学\植物保护学院\副教授（五级）

2019.09-2021.10：山东农业大学\植物保护学院\副教授（七级）

2016.09-2019.06：山东农业大学\农药学专业\博士

2015.07-2016.08：山东农业大学\农药环境毒理研究中心\实验员

2012.09-2015.06：山东农业大学\农药学专业\硕士

2008.09-2012.07：山东农业大学\制药工程专业\学士

教学工作

主要承担本科生科生《仪器分析》、《植物化学保护实验1》、《农药制剂学实验》，硕士研究生《现代农药研究技术》，博士研究生《农药应用工艺学》等课程的教学。

副主编农业农村部规划教材《农药学实验技术与指导（第三版）》1部。

指导本科生获得山东省SRT计划项目，中国国际大学生创新大赛金奖等多项奖励，获“山东农业大学创新创业导师”等荣誉称号。

研究方向

1. 新型微纳米农药负载体系设计及构筑。

2. 农药高效精准对靶沉积技术及调控。

科研项目

1. 中国科协青年人才托举工程，2022.12-2024.12，30万元，主持。

2. 国家自然科学基金青年项目，吡唑醚菌酯微粒二次分散结构与施用药效的关联机制及调控，2021.01-2023.12，24万元，主持。

3. 国家重点研发计划子课题，设施蔬果根腐病绿色防控技术与产品研发，2023.12-2027.12，24.07万元，主持。

4. 中国博士后科学基金项目，连接臂依赖的腐植酸基纳米农药负载体系构筑及调控机理研究，2023.11-，8万元，主持。

5. 中央引导地方科技发展专项资金项目，枸杞蚜虫、木虱的绿色防控关键技术研发与应用，2022.11-2024.11，50万元，主持。

6. 山东省高等学校青创科技支持计划，生物基纳米农药负载体系构建及调控机制研究，2023.01-2025.12，30万元，主持。

7. 山东省自然科学基金项目，微囊化负载降低高鱼毒吡唑醚菌酯施用风险的机制及调控研究，2021.01-2023.12，15万元，主持。

8. 山东农业大学科研启动基金，农药靶界面行为与药效的耦合机制及调控，50万元，主持。

9. 山东滨农科技有限公司，氟吡菌酰胺防治作物病害应用技术，2021.12-2022.12，20万元，主持。

10. 山东滨农科技有限公司，不同剂型氟吡菌酰胺单剂及混剂开发，2023.01-2023.12，12万元，主持。

代表性科研成果

1. Tong-fang Jing, Da-xia Zhang, Yao-zhong Zhang, Yan Jin, Xian-zheng Han, Wei Mu, Bei-xing Li*, Feng Liu*. Adsorption behaviour and mechanism of Avermectin-based pesticides in soil driven by H-bonds formed between the compounds and humus. Chemical Engineering Journal, 2023, 459, 141647.

2. Haichao Cao, Yue Chen, Zhigang Qian, Tingjie Huang, Nan Zou, Daxia Zhang, Wei Mu, Beixing Li*, Feng Liu*. Amphiphilicity-driven amall alcohols regulate the flexibility of pesticide-loaded microcapsules for better foliar adhesion and utilization. ACS Appl. Mater. Interfaces, 2023, 15, 21444-21456.

3. Aiping Wang, Yue Sun, Zhengyi Sun, Xiao Liu, Xin Yu, Ke Li, Xianxia Zhang, Yue Xu, Wei Mu, Beixing Li*. Modification of sedimentation and bioaccumulation behavior as an efficient strategy to modulate the toxicity of pyraclostrobin to zebrafish (Danio rerio). Environmental Pollution, 2023, 322, 121164.

4.Jiang Du, Chonglin Wang, Yukun Liu, Chaobin Xue, Jiacheng Ge, Guodong Si, Xianzheng Han, Feng Liu, Daxia Zhang*, Beixing Li*. One-pot construction of epoxy resin nanocarrier delivering abamectin and its efficacy on plant root-knot nematodes. Pest Management Science, 2023, 79, 3103-3113.

5. Y. Gao, J. Luo, Y. Sun, H. Zhang, D. Zhang, F. Liu, W. Mu*, B. Li*. Photosensitivity and a precise combination of size-dependent lambda-cyhalothrin microcapsules synergistically generate better insecticidal efficacy. Journal of Integrative Agriculture, 2023, 22(5): 1477-1488.

6. X. Huang, A. Wang, J. Luo, Y. Gao, L. Guan, P. Zhang, F. Liu, W. Mu, B. Li*. Lambda-cyhalothrin-loaded nanocapsules pose an unacceptable acute toxicological risk to zebrafish (Danio rerio) at the adult and larval stages but present an acceptable risk to embryos. J. Hazard. Mater., 2022, 422, 126853.

7. J. Luo, Y. Gao, Y. Liu, X. Huang, D. Zhang, H. Cao, T. Jing, F. Liu,* B. Li*. Self-assembled degradable nanogels provide foliar affinity and pinning for pesticide delivery by flexibility and adhesiveness adjustment. ACS Nano, 2021, 15, 14598−14609.

8. J. Luo, Y. Gao, Y. Liu, J. Du, D. Zhang, H. Cao, T. Jing, B. Li*, F. Liu*. Using a reactive emulsifier to construct simple and convenient nanocapsules loaded with lambda-cyhalothrin to achieve efficient foliar delivery and insecticidal synergies. Nanoscale, 2021, 13, 15647–15658.

9. H. Cao, D. Zhang, S. Liu, J. Luo, T. Jing, S. Pan, F. Liu, B. Li*, W. Mu*. Achieving win-win ecotoxicological safety and fungicidal activity of pyraclostrobin-loaded polyurea microcapsules by selecting proper polyamines. J. Agric. Food Chem., 2021, 69(7), 2099-2107.

10. X. Li, L. He, X. Pang, Y. Gao, Y. Liu, P. Zhang, G. Wei, W. Mu, B. Li*, F. Liu*. Tank-mixing adjuvants enhanced the efficacy of fludioxonil on cucumber anthracnose by ameliorating the penetration ability of active ingredients on target interface. Colloid. Surface. B, 2021, 204, 111804.

11. S. Pan, H. Cao, B. Li*, D. Zhang, W. Mu, F. Liu*. Improving the efficacy against crop foliage disease by regulating fungicide adhesion on leaves with soft microcapsules. Pest Manag. Sci., 2021, 77(10), 4418-4424.

12. X. Li, Y. Liu, L. He, Y. Gao, W. Mu, P. Zhang, B. Li,* F. Liu*. Fungicide formulations influence their control efficacy by mediating physicochemical properties of spray dilutions and their interaction with target leaves. J. Agric. Food Chem., 2020, 68(5), 1198-1206.

13. B. Li, Y. Liu, P. Zhang, X. Li, X. Pang, Y. Zhao, H. Li, F. Liu, J. Lin, W. Mu∗. Selection of organosilicone surfactants for tank-mixed pesticides considering the balance between synergistic effects on pests and environmental risks. Chemosphere, 2019, 217, 591-598.

14. Y. Gao, X. Li, L. He, B. Li,* W. Mu, F. Liu*. Role of adjuvants in the management of anthracnose change in the crystal morphology and wetting properties of fungicides. J. Agric. Food Chem., 2019, 67, 9232−9240.

15. B. Li,# Y. Ren,# D. Zhang, S. Xu, W. Mu, F. Liu*. Modifying the formulation of abamectin to promote its efficacy on southern root-knot nematode (Meloidogyne incognita) under blending-of-soil and root-irrigation conditions. J. Agric. Food Chem., 2018, 66, 799−805.

16. B. Li,# J. Lin,# X. Pang,# H. Li, X. Li, F. Liu, W. Mu*. Binary mixtures of alcohol ethoxylates, nonylphenol ethoxylates and pesticides exhibit comparative bioactivity against three pests and toxicological risks to aquatic organisms. Chemosphere, 2018, 204, 44-50.

17. B. Li, X. Li, Y. Liu, D. Zhang, J. Lin, W. Mu, F. Liu*. Easily tunable membrane thickness of microcapsules by using a coordination assembly on the liquid-liquid interface. Front. Chem., 2018, 6, 387.

18. B. Li,# X. Pang,# P. Zhang,# J. Lin, X. Li, Y. Liu, H. Li, F. Liu, W. Mu*. Alcohol ethoxylates significantly synergize pesticides than alkylphenol ethoxylates considering bioactivity against three pests and joint toxicity to Daphnia magna. Sci. Total Environ., 2018, 644, 1452-1459.

19. B. Li,# H. Li,# X. Pang,# K. Cui, J. Lin, F. Liu, W. Mu*. Quaternary ammonium cationic surfactants increase bioactivity of indoxacarb on pests and toxicological risk to Daphnia magna. Ecotoxicol. Environ. Safety, 2018, 149, 190-196.

20. B. Li,# W. Wang,# X. Zhang, D. Zhang, Y. Ren, Y. Gao, W. Mu, F. Liu*. Using coordination assembly as the microencapsulation strategy to promote the efficacy and environmental safety of pyraclostrobin. Adv. Funct. Mater., 2017, 27(29), 1701841.

21. B. Li,# W. Wang,# X. Zhang, D. Zhang, W. Mu, F. Liu*. Integrating uniform design and response surface methodology to optimize thiacloprid suspension. Sci. Rep., 2017, 7, 46018.