夏媛媛
夏媛媛
职称:副研究员
学历/学位:研究生/博士
电话:(0510)85918122
电子邮箱:yyxia@jiangnan.edu.cn
长期从事酶工程与合成生物学的研究,主要承担《微生物学》、《微生物遗传育种》、《Protein Engineering》、《理科综合实验》等课程的讲授工作。近年来以第一作者或通讯作者发表论文10余篇,参与出版英文专著1部;申请发明专利40余项,其中授权国际专利2项,授权国内专利10余项;主持国家自然科学基金青年基金1项,主持中国博士后科学基金1项,主持国家重点研发子课题2项,参与国家自然科学基金省部级科研项目2项,主持横向3项;指导本科生参与学科竞赛,获得2020国际基因工程机器大赛(iGEM)金奖,获得2022全国大学生生命科学竞赛二等奖及三等奖等。
2009.9 – 2012.6 江南大学,生命科学与技术人才培养基地强化班,工科学士
2012.9 – 2019.6 江南大学,生物工程学院,发酵工程专业,工学博士
2019.6 – 2024.6 江南大学,生物工程学院,助理研究员
2024.9 – 江南大学,生物工程学院,副研究员
其中:
2018.4 – 2019.4 美国联合生物能源研究所(JBEI),合成生物学,访学
一、论文(论著)发表情况
1. Yujuan Shen, Jiajing Guo, Yuanyuan Xia*, Lai Wei, Xiaoyi Lin, Yuqi Liu, Yuanhong Chen, Yuhao Bao, Haiquan Yang, Xianzhong Chen*. "Production of 2-O-α-d-glucopyranosyl-l-ascorbic acid using sucrose phosphorylase by semi-rational design. " International Journal of Biological Macromolecules 2024, Volume 284, Part 2.
2. Xu, Jie#, Yuanyuan Xia#, Yibo Shi, Manzhi Zhu, Haibing Zhang, Xiaoying Gui, Wei Shen, Haiquan Yang, and Xianzhong Chen. "Metabolic Engineering of Candida tropicalis for the De Novo Synthesis of β-Ionone." ACS Synthetic Biology 2024, 16;13(8):2533-2544.
3. Xia, Yuanyuan,et al. “Construction of an Escherichia coli cell factory for de novo synthesis of tyrosol through semi-rational design based on phenylpyruvate decarboxylase ARO10 engineering.” International Journal of Biological Macromolecules 2023,253(7):127385.
4. Xia, Yuanyuan, et al."Efficient Biosynthesis of Acidic/Lactonic Sophorolipids and Their Application in the Remediation of Cyanobacterial Harmful Algal Blooms. "International Journal of Molecular Sciences. ;24.15(2023):12389.
5. Xia, Yuanyuan, et al. "Discovery of the ATPase Activity of a Cobalt-Type Nitrile Hydratase Activator and Its Promoting Effect on Enzyme Maturation." Biochemistry 61.24 (2022): 2940-2947.
6. Xia, Yuanyuan, et al. "Tailoring the Hinge Residue at the Substrate Access Tunnel Entrance Improves the Catalytic Performance of Industrialized Nitrile Hydratase Toward 3‐Cyanopyridine." ChemistrySelect 7.34 (2022): e202201941.
7. Xia, Yuanyuan, et al. "Significant Improvement of Both Catalytic Efficiency and Stability of Fructosyltransferase from Aspergillus niger by Structure-Guided Engineering of Key Residues in the Conserved Sequence of the Catalytic Domain." Journal of Agricultural and Food Chemistry 70.23 (2022): 7202-7210.
8. Xia, Yuanyuan, et al. "Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol." Applied Microbiology and Biotechnology 105 (2021): 7309-7319.
9. Xia, Yuanyuan, et al. "Metallochaperone function of the self‐subunit swapping chaperone involved in the maturation of subunit‐fused cobalt‐type nitrile hydratase." Biotechnology and Bioengineering 116.3 (2019): 481-489.
10. Xia, Yuanyuan, et al. "Improving the thermostability and catalytic efficiency of the subunit‐fused nitrile hydratase by semi‐rational engineering." ChemCatChem 10.6 (2018): 1370-1375.
11. Xia, Yuanyuan, et al. "Construction of a subunit-fusion nitrile hydratase and discovery of an innovative metal ion transfer pattern." Scientific Reports 6.1 (2016): 19183.
二、专利情况
1.Fused NHase with improved specific activity and stability. U.S. Patent. US9896679B2(授权)
2.Fused NHase with improved specific activity and stability. U.S. Patent. US9670474B2 (授权)
3.一种比酶活和稳定性提高的融合型腈水合酶,CN104862296B(授权)
4.一种比酶活和稳定性提高的融合型腈水合酶,CN104774829B(授权)
5.一种生产羟基酪醇的重组大肠杆菌及其应用,CN2021101760030(授权)
6.一株缩短发酵周期的产酪醇重组大肠杆菌及其应用,CN202110598376.7(授权)
7.一种熊蜂生假丝酵母强组成型启动子及其应用,CN202011156814.6(授权)
8.一种提高酿酒酵母工程菌脂肪酸乙酯产量的方法,CN2021100898359(授权)
9.一种产蔗糖磷酸化酶突变体及其应用,CN2020105068951(授权)
三、承担教学科研项目情况
1.主持国家自然科学基金青年基金1项,亚基融合型腈水合酶钴离子摄取机制解析(32001064),24万元,结题;
2.主持中国博士后科学基金1项,新型亚基融合型腈水合酶成熟机制解析(2020M671331),8万元,结题;
3.主持国家重点研发子课题一项,工业酶活性中心突变体催化效率测定(2021YFC2100102-03),50万元,结题;
4.主持横向3项,总经费29.5万元;
5.参与国家自然科学基金省部级科研项目2项,在研。
四、获奖情况(含指导学生获奖)
1.2020国际基因工程机器大赛(iGEM),金奖,1/25;
2.全国大学生生命科学竞赛(2022,科学探究类)江苏赛区,三等奖,1/2。
以上资料更新时间截止:2024年12月
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