研究方向

致力于微流控生物芯片与纳微尺度生物医学技术相关研究，针对“生物”国家战略性新兴产业与世界科技前沿，探索生物医学工程和分析化学领域的前沿科学问题，研发面向单细胞分析、液体活检以及体外快速诊断的创新技术、方法和仪器。

一作及通讯作者论文

[32] Li, P. J.,Chen, P.,Qi, F. K., et al. High-throughput and proteome-wide discovery of endogenous biomolecular condensates. Nat Chem, Mar 18, 2024.

[31] Li, S.,Wan, C.,Xiao, Y., et al. Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid. Lab Chip, May 24, 2024.

[30] Qian, C.,Li, P.,Wang, J., et al. Centrifugo-Pneumatic Reciprocating Flowing Coupled with a Spatial Confinement Strategy for an Ultrafast Multiplexed Immunoassay. Anal Chem, May 7, 2024, 96 (18): 7145-7154.

[29] Wan, C.,Yi, L.,Yuan, H., et al. Atmospheric Pressure Enhanced Self-Sealing Rotation-SlipChip with Programmable Concentration Gradient Generation for Microbiological Applications. Small Methods, May 31, 2024,  e2400454.

[28] Xiao, Y.,Zhou, M.,Liu, C., et al. Fully integrated and automated centrifugal microfluidic chip for point-of-care multiplexed molecular diagnostics. Biosens Bioelectron, Jul 1, 2024, 255 (255): 116240.

[27] Guo, S.,Xie, H.,Zhao, X. D., et al. All-in-one detection of breast cancer-derived exosomal miRNA on a pen-based paper chip. Analyst, Feb 12, 2024, 149 (4): 1250-1261.

[26] Pang, Z.,Li, S.,Wang, S., et al. Controlled-diffusion centrifugal microfluidic for rapid antibiotic susceptibility testing. Anal Chim Acta, Jan 25, 2024, 1287 342033.

[25]  Yuan, H.,Wan, C.,Wang, X., et al. Programmable Gravity Self-Driven Microfluidic Chip for Point-of-Care Multiplied Immunoassays. Small, Dec 12, 2023,  e2310206.

[24]   Qian, C.,Wan, C.,Li, S., et al. On-Line Dual-Active Valves Based Centrifugal Microfluidic Chip for Fully Automated Point-of-Care Immunoassay. Anal Chem, Aug 9, 2023.

[23]   Qian, C.,Li, J.,Pang, Z., et al. Hand-powered centrifugal micropipette-tip with distance-based quantification for on-site testing of SARS-CoV-2 virus. Talanta, Jun 1, 2023, 258 124466.

[22]   Li, S.,Wan, C.,Wang, B., et al. Handyfuge Microfluidic for On-Site Antibiotic Susceptibility Testing. Anal Chem, Apr 11, 2023, 95 (14): 6145-6155.

[21]   Huang, Q.,Xiao, W.,Chen, P., et al. Nanopore membrane chip-based isolation method for metabolomic analysis of plasma small extracellular vesicles from COVID-19 survivors. Biosens Bioelectron, May 1, 2023, 227 115152.

[20]   Zhou, M.,Su, H.,Wang, B., et al. A magnet-actuated microfluidic array chip for high-throughput pretreatment and amplification and detection of multiple pathogens. Analyst, May 30, 2022, 147 (11): 2433-2441.

[19]   Zeng, W.,Chen, P.,Li, S., et al. Hand-powered vacuum-driven microfluidic gradient generator for high-throughput antimicrobial susceptibility testing. Biosens Bioelectron, Jun 1, 2022, 205 114100.

[18]   Yuan, H. J.,Chen, P.,Wan, C., et al. Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19. Trac-Trend Anal Chem, Dec, 2022, 157.

[17]   Yiran Guo, P. C., Zhaolong Gao, Yiwei Li, Shunji Li, Xiaojun Feng,Bi-Feng Liu. A time-coded multi-concentration microfluidic chemical waveform generator for high-throughput probing suspension single-cell signaling. Chinese Chemical Letters, 2022.

[16]   Xiao, Y.,Li, S.,Pang, Z., et al. Multi-reagents dispensing centrifugal microfluidics for point-of-care testing. Biosens Bioelectron, Feb 26, 2022, 206 114130.

[15] Wang, X.,Hong, X. Z.,Li, Y. W., et al. Microfluidics-based strategies for molecular diagnostics of infectious diseases. Mil Med Res, Mar 18, 2022, 9 (1): 11.

[14] Wang, J.,Chen, P.,Dong, Y., et al. Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy. Biomaterials, Sep, 2021, 276 121056.

[13] Qian, C. G.,Xiao, Y. J.,Wang, J., et al. Rapid exosomes concentration and in situ detection of exosomal microRNA on agarose-based microfluidic chip. Sensor Actuat B-Chem, Apr 15, 2021, 333.

[12] Chen, P.,Chen, C.,Su, H., et al. Integrated and finger-actuated microfluidic chip for point-of-care testing of multiple pathogens. Talanta, Mar 1, 2021, 224 121844.

[11] Guo, Y.,Gao, Z.,Liu, Y., et al. Multichannel Synchronous Hydrodynamic Gating Coupling with Concentration Gradient Generator for High-Throughput Probing Dynamic Signaling of Single Cells. Anal Chem, Sep 1, 2020, 92 (17): 12062-12070.

[10] Chen, P.,Li, S.,Guo, Y., et al. A review on microfluidics manipulation of the extracellular chemical microenvironment and its emerging application to cell analysis. Anal Chim Acta, Aug 15, 2020, 1125 94-113.

[9] Chen, P.,Yan, S.,Wang, J., et al. Dynamic Microfluidic Cytometry for Single-Cell Cellomics: High-Throughput Probing Single-Cell-Resolution Signaling. Anal Chem, Jan 15, 2019, 91 (2): 1619-1626.

[8] Chen, P.,Chen, D. J.,Li, S. J., et al. Microfluidics towards single cell resolution protein analysis. Trac-Trend Anal Chem, Aug, 2019, 117 2-12.

[7 Chen, P.,Chen, C.,Liu, Y. H., et al. Fully integrated nucleic acid pretreatment, amplification, and detection on a paper chip for identifying EGFR mutations in lung cancer cells. Sensor Actuat B-Chem, Mar 15, 2019, 283 472-477.

[6] Chen, P.,Feng, X. J.,Yan, S. Q., et al. Precision guided microfluidic chemical perfusion strategy for cell dynamic imaging. Sensor Actuat B-Chem, Jun 15, 2018, 263 281-288.

[5] Yan, S. Q.,Chen, P.,Zeng, X. M., et al. Integrated Multifunctional Electrochemistry Microchip for Highly Efficient Capture, Release, Lysis, and Analysis of Circulating Tumor Cells. Anal Chem, Nov 21, 2017, 89 (22): 12039-12044.

[4] Chen, P.,Guo, Y. R.,Wang, J., et al. A localized chemical pulse generator for the development of a microfluidic cell-based biosensor. Sensor Actuat B-Chem, Nov, 2017, 251 112-119.

[3] Chen, P.,Guo, Y. R.,Feng, X. J., et al. Microfluidic Chemical Function Generator for Probing Dynamic Cell Signaling. Anal Chem, Sep 5, 2017, 89 (17): 9209-9217.

[2] Chen, P.,Feng, X. J.,Chen, D. J., et al. Investigating intercellular calcium waves by microfluidic gated pinched-flow. Sensor Actuat B-Chem, Oct 29, 2016, 234 583-592.

[1] Chen, P.,Chen, P.,Feng, X. J., et al. Analysis of intercellular communication by flexible hydrodynamic gating on a microfluidic chip. Anal Bioanal Chem, Jan, 2013, 405 (1): 307-314.