Biomolecular Functionalized Polymer Composites (BFPC) Innovative Technology Team of HenanProvince

1. Introduction

BFPC is an important innovative technology team of level key disciplines in Henan province, Material science and Engineering, and based on Henan Provincial Key Laboratory of surface interface science, Henan Collaborative Innovation Center of Environmental Pollution Control and Ecological Restoration, and Henan Biological Engineering Technology Center in ZZULI. The scientific research platform possesses fixed assets with the value higher than fifty millions ￥. There are 10 members, including 6 doctors and 7 whose title is higher than Associate Professor. The main research directions mainly focus on immobilization and detection of biomolecules onto the bio-functionalized composites, the synthesis of the organic-inorganic nanocomposites and its application on the rapid quantitative detection of food additives or microbial, the fabrication of multi-funcnationlity organic-inorganic nanocomposite hydrogel and its application on heavy metal ions detection and adsorption in water or environment, and so on.

2. Group

(1) Members：10

(2) Group leader: Dr. Zhihong Zhang

(3) List of group members

3. Research fields

Research direction 1：Immobilization and detection of biomolecules onto the bio-functionalized composites;

Research direction 2:  Synthesis of the organic-inorganic nanocomposites and its application on the rapid quantitative detection of food additives or microbial;

Research direction 3: Fabrication of multi-funcnationlity organic-inorganic nanocomposite hydrogel and its application on heavy metal ions detection and adsorption in water or environment.

4. Research results

[Immobilization mechanism of biomolecules on plasma polymerized pyrrole] Plasma polymerized pyrrole (PPy) was prepared by the new method of plasma polymerization. On the base of the solution performance and conductivity of the developed polymer, the immobilization behavior of the biomolecules on PPy Nano film was investigated in details. Also, the anchored mechanism of DNA molecules on the surface of PPy was further probed after the detailed study of the biocompatibility of PPy.

Schematic diagram of DNA immobilization/hybridization onto plasma polymerized pyrrole and the related prize

 [Fabrication of the electrochemical biosensors based on the biomolecule-templated nanocomposites] Novel inorganic nanocomposites were prepared using one-pot method and probe molecule as template. All kinds of electrochemical approaches were applied to determine the food additives, microbial and proteins.

Schematic representation of the fabrication of Mn₃(PO₄)₂-based biosensors for ractopamine detection.

[Basic investigation of conductive hydrogel-inorganic nanocomposites and its applications on the environmental detection] Three-dimensional conductive hydrogel nanocomposites were synthesized using pyrrole and aniline as monomer and inorganic nanomaterials as inorganic phase. On the base of the performances, the treatment ability of these new hydrogels on organic pollutants, heavy metal ions and microbial in environment was probed.

Schematic diagram of the electrochemical DNA biosensor based on Cu₂O@NCs nanocomposites for detecting Hg²⁺ ions.

Publications:

1. Minghua Wang, Shuyong Zhai, Linghao He, Donglai Peng, Xiaozhong Feng, Yanqin Yang, Shaoming Fang, Hongzhong Zhang*, Zhihong Zhang*, An electrochemical aptasensor based on TiO₂/three-dimensional reduced graphene oxide/PPy nanocomposite for the sensitive detection of lysozyme, Dalton Transactions, 2015, 44,6473-6479.

2. Zhihong Zhang*, Yuanchang Zhang, Linghao He, Yanqin Yang, Shunli Liu, Minghua Wang, Shaoming Fang*, Guodong Fu, A feasible synthesis of Mn₃(PO₄)₂@BSA nanoflowers and its application as the support nanomaterial for Pt catalyst, Journal of Power Sources, 2015,15,170-177.

3. Zhihong Zhang^*, Yuanchang Zhang, Ruirui Song, Minghua Wang, Fufeng Yan, Linghao He, Xiaozhong Feng, Shaoming Fang^* Jihong Zhao, Hongzhong Zhang, Manganese (II) Phosphate nanoflowers as electrochemical biosensors for the high-sensitivity detection of ractopamine, Sensors &Actuators B. Chemical, 2015, 211,310-317.

4. Shunli Liu, Mengmeng Kang, Fufeng Yan, Donglai Peng, Yanqin Yang, Linghao He, Minghua Wang, Shaoming Fang*, Zhihong Zhang^*, Electrochemical DNA Biosensor Based on Microspheres of Cuprous Oxide and Nano-chitosan for Hg(II) Detection, Electrochimica Acta, 2015, 160, 64-73.

5. Mengmeng Kang, Donglai Peng, Yuanchang Zhang, Yanqin Yang, Linghao He, Fufeng Yan, Shumin Sun, Shaoming Fang, Peiyuan Wang^*, Zhihong Zhang^*, Electrochemical sensor rhodamine B hydrazide-immobilized graphene oxide for highly sensitive and selective detection of Cu (II), New Journal of Chemistry, 2015,39, 3137-3144.

6. Mengmeng Kang, Minghua Wang, ShuaiZhang, XiaodongDong, Linghao He, Yonghui Zhang, Dongjie Guo, Peiyuan Wang^*, Shaoming Fang, Zhihong Zhang^*, Highly selective and sensitive reversible sensor for Cu (II) detection based on hollow TiO₂ nanospheres modified by fluorescein hydrozine-3, 6-diacetic acid, Electrochimica Acta, 2015, 161,186-194.

8. Yanqin Yang, Mengmeng Kang, Shaoming Fang, Minghua Wang, Linghao He, Jihong Zhao, Hongzhong Zhang* , Zhihong Zhang*, Electrochemical biosensor based on three-dimensional reduced graphene oxide and polyaniline nanocomposite for selective detection of mercury ions, Sensors &Actuators B. Chemical, 2015,214,63-39.

9. Zhihong Zhang, Shunli Liu, Yu Shi, et al.Label-free aptamer biosensor for thrombin detection on a nanocomposite of graphene and plasma polymerized allylamine. Journal of Materials Chemistry B, 2014, 2(11): 1530-1538.

10. Zhihong Zhang, Shunli Liu, Yuanchang Zhang, et al. Easy amino-group modification of graphene using intermolecular forces for DNA biosensing. RSC Adv. 2014, 4, 16368-16373.

11. Zhihong Zhang, Shunli Liu, Mengmeng Kang, et al. Graphene nanostructures with plasma-polymerized pyrrole as an adsorbent layer for biosensors. Microchim Acta (2014)181:1059–1067.

12. Zhihong Zhang, Shunli Liu, Yu Shi, et al. DNA Detection and Cell Adhesion on Plasma-Polymerized Pyrrole. Biopolymers, 101(5), 2013, 496-503.

13. Yong-Hui Zhang, Mei-Ling Zhang, Ye-Cheng Zhou, Ji-Hong Zhao, Shao-Ming Fang, and Feng Li, Tunable electronic and magnetic properties of graphene-like ZnO monolayer upon doping and CO adsorption: a first-principles study, J. Mater. Chem. A 2014,2,13129-13135.

14. Yong-Hui Zhang, Li-Feng Han, Yuan-Hua Xiao,Dian-Zeng Jia, Zhan-Hu Guo,Feng Li, Understanding dopant and defect effect on H₂S sensing performances of graphene: a first-principles study, Comput. Mater. Sci. 2013, 69, 222-228.

15. Dong-Jie Guo, Hao Zhang, Shao-Ming Fang, et al. Fabrication and adhesion of bio-inspired seta: Capillarity-induced casting of porous silicon, Journal of Materials Chemistry B, 2013, 1, 379-386.

16. Linghao He, Jing Sun, Xiuxin Wang, et al. Facile and effective promotion of β crystalline phase in poly(vinylidene fluoride) via the incorporation of imidazolium ionic liquids. Polymer International, 2013, 62: 638-646.

17.Linghao He, Guangmei Xia, Jing Sun, et al. Unzipped multiwalled carbon nanotubes-incorporated poly(vinylidene fluoride) nanocomposites with enhanced interface and piezoelectric b phase. Journal of Colloid and Interface Science, 2013, 393: 97–103.

18. Long pang, Jingfu Liu, Yongguang Yin, Mohai Shen, Evaluating the sorption of organophosphate esters to different sourced humic acide and its effects on the toxicity todaphnia magna Environmental Toxicology and Chemistry, 2013, 32, 2755-2761.

5. Research projects

6. Photos