姓名：李明慧

 邮箱：liminghui@ynu.edu.cn

 职称：助理研究员

 地址：云南大学呈贡校区化工楼1501

教育经历：

2020.09-2024.07，北京大学，药剂学，博士

2018.09-2020.07，北京大学，药剂学，硕士

2014.09-2018.07，北京大学，药学，学士

工作经历：

2024.12-至今，云南大学药学院/教育部自然资源药物化学重点实验室，助理研究员

2024.07-2024.10，江苏恒瑞医药股份有限公司，制剂中级研究员

研究领域：

1、新型药物递送系统开发

2、基于活性天然产物的创新制剂开发

奖励荣誉：

无

职教课程与教学成果：

无

科研项目：

无

代表性论文：（近五年）

[1] Li M^#, Jiang A^#, Han H, Chen M, Wang B, Cheng Y, Zhang H, Wang X, Dai W^*, Yang W^*, Zhang Q^*, He B^*. A Trinity Nano-Vaccine System with Spatiotemporal Immune Effect for the Adjuvant Cancer Therapy after Radiofrequency Ablation[J]. ACS Nano, 2024,18(5):4590-4612.（JCR/中科院1区，IF 15.8）

[2] Song G^#, Li M^#, Fan S^#, Qin M, Shao B, Dai W, Zhang H, Wang X, He B^*, Zhang Q^*. Boosting synergism of chemo- and immuno-therapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules[J]. Acta Pharmaceutica Sinica B, 2024,14(2):836-853. （JCR/中科院1区，IF 14.7）

[3] Qin M^#, Li M^#, Song G, Yang C, Wu P, Dai W, Zhang H, Wang X, Wang Y, Zhou D, He B^*, Zhang Q^*. Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination[J]. Nano Today, 2021,37:101097. （JCR/中科院1区，IF 13.2）

[4] Li M^#, Qin M^#, Song G, Deng H, Wang D, Wang X, Dai W, He B^*, Zhang H^*, Zhang Q^*. A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens[J]. Asian Journal of Pharmaceutical Sciences, 2021,16(1):97-109. （JCR/中科院1区，IF 10.7）

[5] Yang L^#, Yang Y^#, Zhang J, Li M, Yang L, Wang X, Chen M, Zhang H, He B, Wang X, Dai W^*, Wang Y^*, Zhang Q^*. Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy[J]. Signal Transduct Target Ther, 2024,9(1):275. （JCR/中科院1区，IF 40.8）

[6] Yang A, Sun Y, Lyu B, Chen B, Fan Z, Li M, Zhao Y, Fu J, He B, Zhang H, Wang X, Dai W^*, Zhang Q^*. One-pot preparation of nanodispersion with readily available components for localized tumor photothermal and photodynamic therapy[J]. Asian J Pharm Sci, 2022,17(1):120-128. （JCR/中科院1区，IF 10.7）

[7] Qin M, Zhang J, Li M, Yang D, Liu D, Song S, Fu J, Zhang H, Dai W, Wang X, Wang Y, He B^*, Zhang Q^*. Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions[J]. Theranostics, 2020,10(3):1213-1229. （JCR/中科院1区，IF 12.4）