（一）本组简介

本组主要负责人为葛胜祥教授，现有教师3名、高级工程师2名、中级工程师2名、博士后1名、在读博士生12名、在读研究生33名、技术员3名，是一支富有创新性和凝聚力的研究小组。本组的主要研究方向为体外诊断技术平台与诊断产品研发，旨在提高重大传染病和肿瘤、心血管疾病等重大慢性疾病的体外诊断水平。此外，在传染病流行病学、基因工程疫苗等方面也开展了大量的工作。本组注重科研成果的产业化，获得专利授权70余项，其中境外专利40余项；研制的体外诊断产品已获国家药品监督管理局医疗器械注册证书120余项，并获得保护WHO PQ、FDA等海外注册证书30余项；研究的轮状病毒基因工程疫苗已进入产业化阶段。

（二）导师

葛胜祥，博士，教授，博士生导师，Email:sxge@xmu.edu.cn

李廷栋，博士，高级工程师，Email:litingdong@xmu.edu.cn

张师音，博士，高级工程师，Email:zhangshiyin@xmu.edu.cn

闵小平，博士，副教授，Email:mxp@xmu.edu.cn

杨达候，博士，助理教授，Email:dhyang@xmu.edu.cn

唐自闽，博士，工程师，Email:zimintang@xmu.edu.cn

侯汪衡，博士，工程师，Email:houwangheng@xmu.edu.cn

（三）正在开展的项目

1.体外诊断技术：基于微流控的分子POCT平台、超敏免疫检测技术、miRNA高敏检测方法、外泌体直接捕获检测技术

2.体外诊断检测靶标：活动性结核检测靶标、新型鼻咽癌筛查靶标、新冠抗体检测新靶标、胰腺癌检测新靶标

3.基因工程疫苗：轮状病毒基因工程疫苗及其保护机制研究

4.其他：大分子胞内递送系统、基于人工智能的小蛋白从头设计

（四）近5年来发表的部分文章

[1]   Zhang Shiyin,Su Xiaosong,Wang Jin et al. Nucleic Acid Testing for Coronavirus Disease 2019: Demand, Research Progression, and Perspective.[J] .Crit Rev Anal Chem, 2022, 52: 413-424.

[2]   Zeng Yuanjun,Song Feibo,Luo Guoxing et al. Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses.[J] .Antiviral Res, 2022, 207: 105407.

[3]   Tang Zi-Min,Wen Gui-Ping,Ying Dong et al. Profile of clinical characteristics and serologic markers of sporadic hepatitis E in a community cohort study.[J] .Emerg Microbes Infect, 2023, 12: 2140613.

[4]    Zhong Zecheng,Wang Jin,He Shuizhen et al. An encodable multiplex microsphere-phase amplification sensing platform detects SARS-CoV-2 mutations.[J] .Biosens Bioelectron, 2022, 203: 114032.

[5]   Luo Guoxing,Zeng Yuanjun,Yang Han,Li Yijian, Yang Lianwei, Li Cao, Song Feibo, Zhang Shiyin, Li Tingdong, Ge Shengxiang, Zhang Jun, Xia Ningshao et al. Bivalent rotavirus VP4∗ stimulates protective antibodies against common genotypes of human rotaviruses.[J] .iScience, 2022, 25: 105099.

[6]   Li Cao,Luo Guoxing,Zeng Yuanjun,Song Feibo, Yang Han, Zhang Shiyin, Wang Yingbin, Li Tingdong, Ge Shengxiang, Xia Ningshao. Establishment of Sandwich ELISA for Quality Control in Rotavirus Vaccine Production.[J] .Vaccines (Basel), 2022, 10.

[7]   Yu S#, Yang H#, Li T#, Pan H#, Ren S, Luo G, Jiang J, Yu L, Chen B, Zhang Y, Wang S, Tian R, Zhang T, Zhang S, Chen Y, Yuan Q*, Ge S*, Zhang J, Xia N*. Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo. Nature Communications. 2021;12(1).

[8]   Huang Y#, Wang H#, Li T#, Li C#, Tang J, Yu H, Guo X, Song Q, Wei F, Wang J, Liang C, Zheng F, Li H, Li H, Wu H, Lu Z, Su Y, Wu T, Ge S*, Fu T-M*, Zhang J*, Xia N. Comparison of detection strategies for screening and confirming congenital cytomegalovirus infection in newborns in a highly seroprevalent population: a mother-child cohort study. Lancet Regional Health-Western Pacific. 2021;12:100182

[9]   Xu J#, Wang J#, He S, Su X, Zhong Z, Zhong W, Yan L, Huang S, Yang J, Gao R, Zhang J, Zeng J, Zhang D, Li T, Zhang S*, Ge S*, Zhang J, Xia N. Accurate nucleic acid quantification in a single sample tube without the need for calibration. Analytica Chimica Acta. 2021;1167.

[10]  Xu J#, Wang J#, Su X, Qiu G, Zhong Q, Li T, Zhang D, Zhang S*, He S*, Ge S, Zhang J, Xia N. Transferable, easy-to-use and room-temperature-storable PCR mixes for microfluidic molecular diagnostics. Talanta. 2021;235.

[11]  Huang Y, Li T, Yu H, Tang J, Song Q, Guo X, Wang H, Li C, Wang J, Liang C, Yao X, Qiu L, Zhuang C, Bi Z, Su Y, Wu T, Ge S*, Zhang J*. Maternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population. Emerging Microbes & Infections. 2021;10(1):1824-31.

[12]  ZHAO J, YUAN Q, WANG H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 [J]. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020.

[13]  LOU B, LI T D, ZHENG S F, et al. Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset [J]. Eur Respir J, 2020, 56(2):

[14]  ZHANG J, SU X, XU J, et al. A point of care platform based on microfluidic chip for nucleic acid extraction in less than 1 minute [J]. Biomicrofluidics, 2019, 13(3): 034102.

[15]  LIU W, LIANG H, WANG S, et al. Transcriptional response of USP18 predicts treatment outcomes of interferon-alpha in HBeAg-positive chronic hepatitis B patientsefere [J]. J Viral Hepat, 2019, 26(9): 1050-8.

[16]  GUO X, LI T, LI F, et al. Intermittent abortive reactivation of Epstein-Barr virus during the progression of nasopharyngeal cancer as indicated by elevated antibody levels [J]. Oral Oncol, 2019, 93(85-90.

[17]  LI T, GUO X, JI M, et al. Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma [J]. Cancer Med, 2018, 7(4): 1458-67.

[18]   ZHUO Z, WANG J, CHEN W, et al. A Rapid On-Site Assay for the Detection of Influenza A by Capillary Convective PCR [J]. Mol Diagn Ther, 2018, 22(2): 225-34.

（五）本组优势

本组在体外诊断技术平台、诊断产品研发等方面与生物医药企业、医院、疾控中心等开展深入的合作，采取“理、工、医”结合的培养模式，注重科研成果转化，学生可以从基础研究到成果产业化的流程中获得丰富的经验。

组内技术平台完善，研究兴趣广泛，就业形势良好，团队氛围融洽，注重学生科研创新能力及综合素质的提升，欢迎广大学子加入！

（六）招生要求

生物学各专业、预防医学、医学检验技术、计算机专业、基础医学或临床医学各专业，其他专业学生若有兴趣可邮件联系。