2012年，厦门大学生物学专业，学士学位；
2017年，清华大学生物学专业，博士学位；
2017-2021年，中国科学院深圳先进技术研究院，博士后/副研究员；
2018年，入选中国科学院青年创新促进会；
2019年，入选中国科协青年人才托举工程；
2021年，获广东省自然科学基金杰出青年基金项目资助；
2022年至今，厦门大学生命科学学院，教授；
2022年获国家自然科学基金优秀青年基金资助；
2022年入选厦门大学南强青年拔尖人才A类；
2023年，入选福建省引才百人计划；
B.S. 2012, Xiamen University, Biology;
Ph.D. 2017, Tsinghua University, Biology;
Postdoctoral Fellow/Associate Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 2017-2021;
Professor, School of Life Sciences, Xiamen University, 2022 to Present.

基因组的设计与合成可显著扩大序列改造的规模，有望突破现有的基因组功能认知，拓展人工生命体的应用。课题组负责人前期参与了世界首个真核生物基因组合成计划，构建了百万碱基级别的真核生物线性合成染色体，首次鉴定了组蛋白2-hydroxyisobutyrylation的修饰酶和去修饰酶，联合发起Sc3.0酵母基因组精简与再造国际合作计划，开创的MRA层级组装技术和ReSCuES筛选技术解决了合成染色体设计、构建和应用等方面的系列难点，成果发表在Science（封面专刊）、Cell Res、Nat Commun和Genome Biol等期刊上，为将合成酵母菌应用于代谢工程生产具有重要经济和应用价值的产品提供了崭新的合成基因组学模式。研究成果入选2021年度深圳市自然科学一等奖、2017年度中国高等学校十大科技进展和中国科学十大进展等，被国际同行认为是领域内的里程碑事件，被科技部认为标志着我国真核人工基因组合成研究水平进入国际前列。本课题组未来将继续致力于基因组相关的基础理论研究、关键技术突破和新型应用开发。
Synthetic genomics is an important part of synthetic biology, which is expected to innovate our understanding about genome function and to significantly improve the depth and ability of genome engineering. We participated in the world's first eukaryotic genome synthesis project, constructed a eukaryotic linear synthetic chromosome at the megabase level, identified the Writers and Erasers of histone 2-hydroxyisobutyrylation, co-initiated the Sc3.0 international project on yeast genome minimization and revamping, and created technologies for synthetic chromosome design, construction and application. Our results have been published in journals such as Science (cover story and special issue), Cell Res, Nat Commun and Genome Biol. In the future, our research group will continue to focus on the basic theories, key technologies and new applications related to genome.

代表性论文(^# co-first author, ^* Corresponding author):

1. Z. Luo, J. Dai, Strategic codon selection for enhanced genetic code expansion. Sci China Life Sci. (2024) doi: 10.1007/s11427-024-2758-2.
2. L. Cheng^*, S. Zhao^*, T. Li^*, S. Hou^*, Z. Luo, J. Xu, W. Yu, S. Jiang, M. Monti, D. Schindler, W. Zhang, C. Hou, Y. Ma, Y. Cai, JD. Boeke, J. Dai^#, Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae. Nat. Commun. (2024) 15(1):770.
3. L. Sun^*, X. Chen^*, C. Song^*, W. Shi^*, L. Liu^*, S. Bai^*, X. Wang, J. Chen, C. Jiang, S. Wang, Z. Luo, R. Wang^#, Y. Wang^#, Q. Jin^#, Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress. Elife. (2024)13:RP97896. doi: 10.7554/eLife.97896.
4. S. Jiang^*, Z. Luo^*, J. Wu, K. Yu, S. Zhao, Z. Cai, W. Yu, H. Wang, L. Cheng, Z. Liang, H. Gao, M. Monti, D. Schindler, L. Huang, C. Zeng, W. Zhang, C. Zhou, Y. Tang, T. Li, Y. Ma, Y. Cai, JD. Boeke, Q. Zhao^#, J. Dai^#, Building a eukaryotic chromosome arm by de novo design and synthesis. Nat. Commun. (2023) 14(1):7886.
5. JL. Foo^*, S. Kitano^*, AV. Susanto^*, Z. Jin^*, Y. Lin, Z. Luo, L. Huang, Z. Liang, LA. Mitchell, K. Yang, A. Wong, Y. Cai, J. Cai, G. Stracquadanio, JS. Bader, JD. Boeke, J. Dai^#, MW. Chang^#, Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration. Cell Genom. (2023) 3(11):100435.
6. Y. Shen^#*, F. Gao^*, Y. Wang^*, Y. Wang^*, J. Zheng, J. Gong, J. Zhang, Z. Luo, D. Schindler, Y. Deng, W. Ding, T. Lin, R. Swidah, H. Zhao, S. Jiang, C. Zeng, S. Chen, T. Chen, Y. Wang, Y. Luo, L. Mitchell, JS. Bader, G. Zhang, X. Shen, J. Wang, X. Fu, J. Dai, JD. Boeke, H. Yang, X. Xu, Y. Cai^#, Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast. Cell Genom. (2023) 3(11):100364.
7. Y. Li^*, L. Gao^*, Y. Yao^*, X. Li, Z. Wu, N. Tan, Z. Luo, W. Xie, J. Wu, J. Zhu^#, Altered GC- and AT-biased genotypes of Ophiocordyceps sinensis in the stromal fertile portions and ascospores of natural Cordyceps sinensis. PLoS One. (2023) 18(6):e0286865.
8. Y. Li^*, X. Li^*, Y. Yao^*, Z. Wu, L. Gao, N. Tan, Z. Luo, W. Xie, J. Wu, J. Zhu^#, Differential coexistence of multiple genotypes of Ophiocordyceps sinensis in the stromata, ascocarps and ascospores of natural Cordyceps sinensis. PLoS One. (2023) 18(3):e0270776.
9. S. Bai^*, L. Sun^*, X. Wang, S. Wang, Z. Luo^#, Y. Wang^#, Q. Jin^#, Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism. PLoS Genet. (2022) 18(9):e1010397.
10. Z. Liang^*, Z. Luo^#*, W. Zhang^*, K. Yu, H. Wang, B. Geng, Q. Yang, Z. Ni, C. Zeng, Y. Zheng, C. Li, S. Yang, Y. Ma, J. Dai^#, Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome. iScience. (2022) 25(9):104982.
11. Z. Luo^#*, K. Yu^*, S. Xie, M. Monti, D. Schindler, Y. Fang, S. Zhao, Z. Liang, S. Jiang, M. Luan, C. Xiao, Y. Cai^#, J. Dai^#, Compacting a synthetic yeast chromosome arm, Genome Biol.22 (2021) 1-18.
12. Z. Luo, S. Jiang, J. Dai, Chromosomal Rearrangements of Synthetic Yeast by SCRaMbLE, Methods Mol Biol. (2021) 2196:153-165.
13. S. Jiang, Z. Luo, J. Dai. Use YeastFab to Construct Genetic Parts and Multicomponent Pathways for Metabolic Engineering, Methods Mol Biol. (2021) 2196:167-180.
14. Z. Luo, S. Hoffmann, S. Jiang, Y. Cai^#, J. Dai^#. Probing eukaryotic genome functions with synthetic chromosomes. Exp Cell Res. 390(2020) 111936.
15. J. Dai, J.D. Boeke, Z. Luo, S. Jiang, Y. Cai^#, Sc3.0: revamping and minimizing the yeast genome, Genome Biol. 21(2020) 1-4.
16. Z. Luo^*, L. Wang^*, Y. Wang, W. Zhang, Y. Guo, Y. Shen, L. Jiang, Q. Wu, C. Zhang, Y. Cai^#, J. Dai^#, Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES, Nat. Commun. 9 (2018) 1930.
17. H. Huang^*, Z. Luo^*, S. Qi^*, J. Huang^*, P. Xu, X. Wang, L. Gao, F. Li, J. Wang, W. Zhao, W. Gu, Z. Chen, L. Dai^#, J. Dai^#, Y. Zhao^#, Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway, Cell Res. 28 (2018) 111–125.
18. Z. Luo, Q. Yang, B. Geng, S. Jiang, S. Yang, X. Li, Y. Cai, J. Dai^#, Whole genome engineering by synthesis, Sci. China Life Sci. (2018).1515–1527.
19. W. Liu^*, Z. Luo, Y. Wang, N.T. Pham, L. Tuck, I. Pérez-Pi, L. Liu, Y. Shen, C. French, M. Auer, J. Marles-Wright, J. Dai^#, Y. Cai^#, Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods, Nat. Commun.9 (2018) 1936.
20. J. Lu, Z. Luo, S. Jiang, Y. Shen, Y. Wu, H. Yang, Y. Yuan, J. Dai^#, Technologies for DNA Synthesis, Assembly, and Transplantation. Bulletin of Chinese Academy of Sciences, 33(2018) 1174-1183.
21. B. Li, Y. Wu, Z. Xie, Y. Shen, Y. Wang, W. Zhang, G. Zhao, Z. Luo, J. Dai, H. Yang, Y. Yuan^#, Precise Synthesis of Designer Large Chromosomes of Saccharomyces cerevisiae. Frontier Science, 12(2018) 55-59.
22. W. Zhang^*, G. Zhao^*, Z. Luo^*, Y. Lin, L. Wang, Y. Guo, A. Wang, S. Jiang, Q. Jiang, J. Gong, Y. Wang, S. Hou, J. Huang, T. Li, Y. Qin, J. Dong, Q. Qin, J. Zhang, X. Zou, X. He, L. Zhao, Y. Xiao, M. Xu, E. Cheng, N. Huang, T. Zhou, Y. Shen, R. Walker, Y. Luo, Z. Kuang, L.A. Mitchell, K. Yang, S.M. Richardson, Y. Wu, B.-Z. Li, Y.-J. Yuan, H. Yang, J. Lin, G.-Q. Chen, Q. Wu, J.S. Bader, Y. Cai, J.D. Boeke, J. Dai^#, Engineering the ribosomal DNA in a megabase synthetic chromosome, Science.355 (2017) eaaf3981.
23. J. Huang^*, Z. Luo^*, W. Ying^*, Q. Cao, H. Huang, J. Dong, Q. Wu, Y. Zhao, X. Qian^#, J. Dai^#, 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci. 114 (2017) 8782–8787.
24. Z. Luo, J. Dai, Synthetic genomics: the art of design and synthesis, Chin. J. Biotechnol. 33 (2017) 331–342.
25. Y. Shen^*, Y. Wang^*, T. Chen^*, F. Gao, J. Gong, D. Abramczyk, R. Walker, H. Zhao, S. Chen, W. Liu, Y. Luo, C.A. Müller, A. Paul-Dubois-Taine, B. Alver, G. Stracquadanio, L.A. Mitchell,Z. Luo, Y. Fan, B. Zhou, B. Wen, F. Tan, Y. Wang, J. Zi, Z. Xie, B. Li, K. Yang, S.M. Richardson, H. Jiang, C.E. French, C.A. Nieduszynski, R. Koszul, A.L. Marston, Y. Yuan, J. Wang, J.S. Bader, J. Dai, J.D. Boeke, X. Xu, Y. Cai^#, H. Yang^#, Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome, Science. 355 (2017) eaaf4791.
26. G. Mercy^*, J. Mozziconacci^*, V.F. Scolari, K. Yang, G. Zhao, A. Thierry, Y. Luo, L.A. Mitchell, M. Shen, Y. Shen, R. Walker, W. Zhang, Y. Wu, Z. Xie,Z. Luo, Y. Cai, J. Dai, H. Yang, Y.-J. Yuan, J.D. Boeke, J.S. Bader, H. Muller^#, R. Koszul^#, 3D organization of synthetic and scrambled chromosomes, Science. 355 (2017) eaaf4597.
27. Y. Wang^*, W. Li^*, A.E. Johnson^*, Z. Luo^*, X. Sun, A. Feoktistova, W.H. McDonald, I. McLeod, J.R. Yates, K.L. Gould, D. McCollum^#, Q. Jin^#, Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast, Mol. Biol. Cell. 23 (2012) 3348–3356.

荣誉、奖励及参加学术团体的情况:

Sc2.0 Fellowship Award (University of Edinburgh)，2016年
2017 Cold Spring Harbor Asia Fellowship Award，2017年
带领本科生在全国大学生生命科学竞赛(2024)、全球生物分子设计大赛（BIMOD 2023）、全国合成生物学竞赛(2023)等屡获金奖
厦门大学优秀创新教育指导教师 (本科)，2023年