2000年，厦门大学生物技术专业，学士学位；
2003年，厦门大学大学生物化学与分子生物专业，硕士学位；
2008年，美国德州农工大学生物医学专业，博士学位；
2009-2015年，美国凯斯西储大学，博士后/研究科学家；
2016年至今，厦门大学生命科学学院，特聘教授。
B.S. 2000, Xiamen University, Biotechnology;
M.S. 2003, Xiamen University, Biochemistry and Molecular Biology;
Ph.D. 2018, Texas A&M University, Biomedicine;
Postdoctoral Fellow, Case Western Reserve University, 2009-2015;
Research Scientist, Case Western Reserve University, 2015.06-2016.09;
Professor, School of Life Sciences, Xiamen University, 2016 to Present.

1. 肿瘤代谢与铁死亡；
2. 表观调控与靶向药物筛选系统开发；
3. 多组学肿瘤标记物发现与肿瘤早筛；
4. AI辅助的药物设计与生物材料开发；
5. 合成生物学及IVD诊断用工具酶开发。
1. Cancer Metabolism and Ferroptosis;
2. Epigenetics and Targeting Drug Screening System Development;
3. Multi-Omics for Cancer Biomarker Discovery and Early Cancer Diagnosis;
4. AI-aided Drug Design and Biomaterial Development;
5. Synthesis Biology and IVD Enzyme Development.

代表性论文(^# co-first author, ^* Corresponding author):

1. Zheng H, Chen H, Cai Y, Shen M, Li X, Han Y, Deng X, Cao H, Liu j, Liu B, LI G, Wang X, Chen H, Hou J, Lin S-H, Zong L, Zhang Y^*. Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small-cell lung cancer. Molecular Cell, 2024
2. Liu J, Lu X, Zeng S, Fu R, Wang X, Luo L, Huang T, Deng X, Zheng H, Ma S, Ning D, Zong L, Lin SH, Zhang Y^*. ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer. Redox Biology, 2024
3. Li H, Yu K, Hu H, Zhang X, Zeng S, Li J, Dong X, Deng X, Zhang J, Zhang Y^*. METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer. Redox Biology, 2024
4. Li H, Yu K, Zhang X, Li J, Hu h, Deng X, Zeng S, Dong X, Zhao J, Zhang Y^*. YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response. Genes & Diseases, 2024
5. Li W, Chen M, Wang T, Feng X, Jiang X, Dong X, Zhang H, Tang X, Tian R, Zhang Y^*, Li Z^*. Characterization and humanization of VNARs targeting human serum albumin from the whitespotted bamboo shark (Chiloscyllium plagiosum), Int J Biol Macromol. 2024
6. Ma S, Xiao G, Deng X, Tong M, Huang J, Li Q, Zhang Y. CovidShiny: An Integrated Web Tool for SARS-CoV-2 Mutation Profiling and Molecular Diagnosis Assay Evaluation In Silico. Viruses, 2023
7. Guo P, Chen Q, Peng K, Xie J, Liu J, Ren W, Tong Z, Li M, Zhang Y^*, Yu C^*, Mo P^*, Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. Oncogene, 2022
8. Yan T, Xu Y, Zheng R, Zeng X, Chen Z, Lin S, Xia Z, Liao Y, Zhang Y^*, Li Q^*. Accessible and Adaptable Multiplexed Real-Time PCR Approaches to Identify SARS-CoV-2 Variants of Concern. Microbiol Spectral.2022.
9. Ma S; Zhang Y^*. Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq. Molecular Biomedicine., 2020, 1(1)
10. Antczak MI^*, Zhang Y^#, Wang C, Doran J, Naidoo J, Voruganti S, et al. Inhibitors of 15- Prostaglandin Dehydrogenase To Potentiate Tissue Repair. Journal of Medicinal Chemistry .2017;60: 3979-4001
11. Y. Zhang^#, A, Desai^# S. Yang^# K. Bae^#, M. Antczak^#, S. Fink, S^#. Tiwari^#, et al. S.D. Markowitz, Inhibition of the Prostaglandin Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration. Science.. Jun 12;348(6240), 2015
12. D. Zhou^*, Y. Zhang^#, H. Wu, E. Barry, Y. Yi, E. Lawrence, D. Dawson J.E. Willis, S.D. Markowitz, F.D. Camargo and J. Avruch. The Mst1 and Mst2 kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yap overabundance. PNAS..104(46): 2011
13. Y. Zhang^#, J. Zhang, Y. Lin, Y. Lan, C. Lin, J.W. Xuan, M.M. Shen, W.L. McKeehan,N.M. Greenberg, and F. Wang. Role of epithelial cell fibroblast growth factor receptor substrate 2a in prostate development, regeneration and tumorigenesis. Development.. 135(4):775-84, 200

荣誉、奖励及参加学术团体的情况:

厦门市“杰出青年”，2019年
厦门市“双百计划”，2019年
福建省高层次人才，2020年