2010年，中南民族大学生物工程专业，学士学位；
2015年，华南理工大学生物化工专业，博士学位；
2012-2015年，北京大学基础医学院，访问博士生；
2015-2019年，中国科学院生物物理研究所，博士后/副研究员；
2019年，厦门大学生命科学学院，教授；
2018年入选第四届中国科协青年人才托举工程；
2019年入选厦门大学南强青年拔尖人才A类；
2021年获国家优秀青年科学基金资助
2024年获福建省攻青项目资助
B.S. 2010, South-central University For Nationalities, Bioengineering;
Ph.D. 2015, South China University of Technology, Biochemical Engineering;
Visiting Scholar, Peking University, 2012-2015;
Postdoctoral Fellow/Associate Professor, Chinese Academy of Sciences, 2015-2019;
Professor, School of Life Sciences, Xiamen University, 2019 to Present.

本课题组主要致力于原核生物新型防御系统的挖掘和作用机理研究，近年来，课题组组长以通讯作者(含共同通讯作者)和第一作者(含共同第一作者)在Cell （2篇）、Nature Biotechnology、Molecular Cell （2篇）、Nature Communications、eLife、Structure等专业领域权威TOP期刊发表多篇SCI论文，在针对CRISPR-Cas系统的作用机理方面取得了一系列突破性的研究成果，已申请多项国内和国际专利，对促进新型基因编辑和分子诊断工具的开发和应用具有重要作用。
当前，课题组主要研究方向包括：
1. 基因编辑及分子诊断工具的开发和应用
2. 原核生物防御系统及病毒拮抗宿主免疫的分子机制
3. 核酸加工与修饰
4. RNA介导的基因表达与调控的结构生物学研究

代表性论文(^# co-first author, ^* Corresponding author):

1. Chen J^#*, Lin X^#, Xiang W, Chen Y, Zhao Y, Huang L, Liu L^*. DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems. Nucleic Acids Research. 2024 Dec 16:gkae1241. doi: 10.1093/nar/gkae1241.
2. Chen J^#, Chen Y^#, Huang L^#, Lin X, Chen H, Xiang W, Liu L^*. Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. Nature Biotechnology. 2024; doi: 10.1038/s41587-024-02255-7.
3. Chen J^#, Chen H^#, Li S^#, Lin X, Hu R, Zhang K^*, Liu L^*. Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery. eLife. 2024; 12:RP86847.
4. Chen J^#, Hu R^#, Chen Y^#, Lin X^#, Xiang W, Chen H, Yao C, Liu L^*. Structural basis for MTA1c-mediated DNA N6-adenine methylation. Nature Communications. 2022; 13(1):3257.
5. Liu L, Yin M, Wang M, Wang Y^*. Phage AcrⅡA2 DNA Mimicry: Structural Basis of the CRISPR/anti-CRISPR Arms Race. Molecular Cell. 2019; 73(3):611-620.e3.
6. Liu L^#, Li X^#, Ma J^#, Li Z^#, You L, Wang J, Wang M, Zhang X^*, Wang Y^*. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell. 2017; 170:714-726.
7. Liu L, Li X, Wang J, Yin M, Chen P, Wang M, Li J, Sheng G, Wang Y^*. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. Cell. 2017; 168:121-134.
8. Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y^*. C2c1-sgRNA Complex Structure Reveals RNA-guided DNA Cleavage Mechanism. Molecular Cell. 2017; 65(2):310-322.
9. Liu L^#, Chen JY^#, Yang B, Wang FH, Wang YH^*, Yun CH^*. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function. Structure. 2015; 23:2066-75.
10. Liu L, Chen J, Yang B, Wang Y^*. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem Biophys Res Commun. 2015; 458:429-34.
11. Liu L, Chen J, Yang B, Wang Y^*. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions. FEBS Open Bio. 2015; 5:155-62.
12. Wang P, Zhang L, Chen S, Li R, Liu P, Li X, Luo H, Huo Y, Zhang Z, Cai Y, Liu X, Huang J, Zhou G, Sun Z, Ding S, Shi J, Zhou Z, Yuan R, Liu L, Wu S^*, Wang G^*. ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs. Cell Research. 2024; 34(7):504-521.
13. Sun W^#, Yang J^#, Cheng Z^#, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y^*；Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States；Molecular Cell. 2019; 76(6):938-952.e5.
14. You L^#, Ma J^#, Wang J^#, Artamonva D, Wang M, Liu L, Xiang X, Severinov K, Zhang X^*, Wang Y^*; Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference; Cell. 2019; 176(1-2):239-253.e16.
15. Zhao X, Liu L, Lang J, Cheng K, Wang Y, Li X, Shi J, Wang Y, Nie G^*. A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment. Cancer Lett. 2018; 431:171-181.
16. Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH^*. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Sci Rep. 2016; 6:31425.

荣誉、奖励及参加学术团体的情况:

北京市科学技术奖二等奖（排名第三） ，2018年
Second Prize of Beijing Science and Technology Award，2018年