卢嘉锡讲座

报告题目：Unusual enzyme reactions in natural product biosynthesis

报告时间：2024-12-18 10:00

报告人： Prof. Ikuro Abe

东京大学

报告地点：卢嘉锡楼202报告厅

转播地点：翔安校区能源材料大楼3号楼二层报告厅，漳州校区生化主楼307教室

报告摘要：

Nonheme iron-dependent enzyme reactions play crucial roles in building and modifying bioactive organic molecules in all major classes of natural product pathways. While the enzymes have evolved to use a limited repertoire of protein folding and metal binding sites, the oxidation reactions they catalyze are astonishingly diverse, spanning from complex rearrangements to uncommon bond formation and cleavage reactions. This presentation will summarize recent discoveries that have significantly expanded our understanding of unusual nonheme iron enzyme catalysis in natural product biosynthesis.

报告人简介： 

    Ikuro Abe教授于1989年获日本东京大学博士学位，先后在法国、美国从事研究并担任教职，现为日本东京大学药学院教授。主要从事天然产物生物合成及相关催化酶研究，尤其是非血红素铁酶，P450酶，三萜环化酶及聚酮合成酶等，在Nature, Nature Chemistry, Nature Catalysis, JACS，PNAS，Chem. Rev.等杂志发表论文100余篇，曾获日本生药学会科学贡献奖。

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