南强学术讲座（第1235期）

报告题目：Asymmetric Direct Transformations of Aromatic Compounds

报告时间：2023-12-11 10:00

报告人： 游书力 院士

中国科学院上海有机化学研究所

报告地点：化学报告厅

转播地点：翔安校区能源材料大楼3号楼报告厅，漳州校区生化主楼307教室

报告摘要：

In this talk, the progress from the You laboratory on the development of asymmetric direct C-H functionalization of aromatic compounds and catalytic asymmetric dearomatization processes will be introduced.

Transition-metal-catalyzed asymmetric C–H bond functionalization reactions have attracted much attention over the past few years. In addition to the majority of the work focusing on the installation of central chirality, asymmetric C-H functionalization reactions for the construction of planar chirality, axial chirality and helical chirality have been carried out.

Asymmetric dearomatization reactions are particularly attractive methods in organic synthesis given the facts that the starting materials arenes are highly abundant and readily available, and the dearomatization reaction would provide direct access to polycylces and spirocycles bearing quaternary stereogenic center. However, due to the extra stability of “aromaticity” of the arenes, their dearomatization reaction with good enantioselective control has been a challenge. The You group has developed a series of asymmetric dearomatization reactions of various aromatic compounds.

报告人简介： 

游书力，中国科学院院士，中国科学院上海有机化学研究所研究员、党委副书记（主持）、副所长，中科院上海有机所金属有机国家重点实验室主任。主要从事过渡金属催化的反应、绿色化学及药物化学导向的新反应方法和技术研究。在国际上率先提出“催化不对称去芳构化（CADA）”策略，并受到同行的广泛认可和关注。目前在国内外主流学术期刊上发表研究论文约四百篇，包括Science，Nature Chemistry，Nature Catalysis，JACS等。曾获2019年度科学探索奖，2017/2018 Novartis Chemistry Lectureship，2017年度国家自然科学奖二等奖（第一完成人），2016年度上海市自然科学奖二等奖（第一完成人），2016年度何梁何利基金青年创新奖等。担任化学领域顶尖期刊JACS副主编及多个国内外期刊主编和编委。

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