*个人及工作简历
受教育经历：
2012/-2016/12，西安交通大学，肿瘤学，博士
2005/09－2008/07，西安交通大学，肿瘤学，硕士
2000/09－2005/07，新乡医学院，临床医学，学士
研究工作经历（按时间倒排序）：
2018/01－至今，西安交通大学第一附属医院 乳腺外科，副主任医师
2016/01－至今，西安交通大学第一附属医院 乳腺外科，副研究员
2014/01－2017/12，西安交通大学第一附属医院 乳腺外科，主治医师
2008/11－2013/12，西安交通大学第一附属医院 肿瘤外科，住院医师
*研究领域（方向）
乳腺癌的基础与临床研究
*科研项目
国家自然科学基金：LKB1-AMPK激酶通过调控Hippo信号通路参与维持乳腺上皮细胞染色质稳定性的机制研究（Grant No：81502413）；
陕西省重点研发计划项目：S100A10通过调控自噬影响人乳腺癌细胞染色体稳定性的机制研究（Grant No：2019SF-145）；
*学术集科研成果、专利、论文
[1]Zhou C, He JJ, Li J, Fan JH, Zhang B, Yang HJ, Xie XM, Tang ZH, Li H, Li JY, Wang SL, Qiao YL, Huang R, Zhang P, A Nation-Wide multicenter 10-year (1999-2008) retrospective clinical study of endocrine therapy for Chinese females with breast cancer[J]. PLoS One, 2014,9(7):e100159 .
[2]Zhou Can, Li Zhang, Hua Wang, Xiaoxia Ma, Bohui Shi, Wuke Chen,Jianjun He, Ke Wang, Peijun Liu, Yu Ren .Superiority of Minimally InvasiveOesophagectomy in Reducing In-Hospital Mortality of Patients with ResectableOesophageal Cancer: A Meta-Analysis[J]. PLoS One, 2015,10(7): e0132889.
[3]Zhou C, Ren Y, Li J, Wang K, He J, Chen W, Liu P, Association between Irrigation Fluids, Washout Volumes and Risk of Local Recurrence of Anterior Resection for Rectal Cancer：A Meta-analysis of 427 cases and 492 controls[J]. PLoS One, 2014, 9(5):e95699 .
[4]Zhou C, Ren Y, Li J, Li X, He J, Liu P,Systematic review and meta-analysis of Rectal Washout on Risk of Local Recurrence for cancer[J]. J Surg Res, 2014, 189(1):7-16.
[5]Zhou C, Ren Y, Wang K, Liu J, He JJ, Liu PJ,Intra-operative Rectal Washout with Saline Solution Can Effectively Prevent Anastomotic Recurrence: a Meta-analysis[J]. Asian Pac J Cancer Prev, 2013,14(12):7155-7159.
[6]Can Zhou, Gang Ma,Xiao Li, Juan Li, Yu Yan, Wuke Chen, Peijun Liu,Jianjun He, Yu Ren. Is minimally invasive esophagectomy effective forpreventing anastomotic leakages after esophagectomy for cancer? A systematicreview and meta-analysis[J]. World J Surg Oncol, 2015:13:269.
[7]Li P, Zhou C＃, Yan Y, Li J, Liu J, Zhang Y, Liu P.Crumbs protein homolog 3 (CRB3) expression is associated with oestrogen and progesterone receptor positivity in breast cancer.Clin Exp Pharmacol Physiol. 2019,46(9):837-844.
[8]Ge G, Zhou C＃, Ren Y, Tang X, Wang K, Zhang W, Niu L, Zhou Y, Yan Y, He J.Enhanced SLC34A2 in breast cancer stem cell-like cells induces chemotherapeutic resistance to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling[J]. Tumour Biol,2016, 37(4):5049-5062.
[9]Ma G, Pan Y, Zhou C, Sun R, Bai J, Liu P, Ren Y, He J. Mitogen-activated protein kinase phosphatase 1 is involved in tamoxifen resistance in MCF7 cells[J]. Oncol Rep, 2015,34(5): 2423- 2430.
[10]Mao X, Li P, Ren Y, Li J, Zhou C, Yang J, Liu P.CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.Int J Oncol. 2015,46(2):657-66.
[11]Feng X, Zhang M, Wang B, Zhou C, Mu Y, Li J, Liu X, Wang Y, Song Z, Liu P.CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.J Exp Clin Cancer Res. 2019,38(1):361. doi: 10.1186/s13046-019-1345-2；
[12]Wang K, Li X, Zhou C, Ren Y, Wang XB, He JJ.Socio-economic Factors Influencing Tumor Presentation and Treatment Options in Chinese Breast Cancer Patients[J].Asian Pac J Cancer Prev,2013,14(1):267-274.
[13]Mao X, Li P, Ren Y, Li J, Zhou C, Yang J, Liu P Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma[J]. Int J Oncol, 2015, 46(2): 657-666.
[14]Li J, Liu J, Li P, Zhou C, Liu P.The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.Exp Biol Med (Maywood). 2018,243(13):1066-1073.
[15]Li J, Liu J, Liang Z, He F, Yang L, Li P, Jiang Y, Wang B, Zhou C, Wang Y, Ren Y, Yang J, Zhang J, Luo Z, Vaziri C, Liu P.Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth.Sci Rep. 2017,7:42125.
[16]Wang JC, Li GY, Wang B, Han SX, Sun X, Jiang YN, Shen YW, Zhou C, Feng J, Lu SY, Liu JL, Wang MD, Liu PJ.Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation.J Exp Clin Cancer Res. 2019 ,38(1):235.
[17] Feng X, Zhang M, Wang B, Zhou C, Mu Y, Li J, Liu X, Wang Y, Song Z, Liu P.CRABP2 Regulates Invasion and Metastasis of Breast Cancer Through Hippo Pathway Dependent on ER Status.J Exp Clin Cancer Res. 2019,38(1):361.
[18] Wang B, Zhu L, He C, Tai M, Zhou C, Ge G, Zhang H, He J, Wang K.Growth Pattern Can Be Used as a New Characteristic to Predict Malignancy in Breast Cancer.Breast Cancer. 2020,27(3):445-455.
[19] 周灿,牛利刚,闫宇等.MDT模式下PBL教学法在乳腺外科临床教学实践的应用和探讨[J].中国医学创新,2017,14(29):61-65.DOI:10.3969/j.issn.1674-4985.2017.29.016.
[20] 周灿,王珂,何建军等.不同年龄段女性乳腺癌患者临床病理特征的回顾性分析[J].西安交通大学学报（医学版）,2013,34(1):133-137.DOI:10.3969/j.issn.1671-8259.2013.01.033.
[21] 周灿,陈武科,何建军等.PPARγ蛋白与PTEN蛋白表达及其相关性在人乳腺癌中的研究[J].现代肿瘤医学,2009,17(12):2310-2313.DOI:10.3969/j.issn.1672-4992.2009.12.022.
[22] 周灿,陈武科,何建军等.PPARγ蛋白与PTEN蛋白表达及其相关性在人乳腺癌中的研究[C].//第四届全国肿瘤诊疗新进展及新技术学术会议论文集.2009:135-137.
[23] 闫宇,周灿.中美两国女性乳腺癌临床病理特征及治疗的对比研究[J].现代肿瘤医学,2019,27(8):1344-1351.DOI:10.3969/j.issn.1672-4992.2019.08.014.
[24] 王珂,周灿,谢四梅等.患者职业对乳腺癌临床病理特征及治疗模式的影响[J].西安交通大学学报（医学版）,2013,34(2):218-223.DOI:10.3969/j.issn.1671-8259.2013.02.019.
[25] 任予,周灿,何建军等.西北地区1999-2008年单中心女性乳腺癌临床流行病学特征分析[J].中华肿瘤防治杂志,2013,20(17):1300-1305.DOI:10.3969/j.issn.1673-5269.2013.17.003.
[26] 陈武科,周灿,何建军等.PPARγ及其配体与乳腺癌[J].现代肿瘤医学,2009,17(2):353-356.DOI:10.3969/j.issn.1672-4992.2009.02.069.
[27] 蒋依娜,王博,周灿等.568例HER2不确定乳腺癌原位杂交结果分析[J].肿瘤防治研究,2019,46(7):605-609.DOI:10.3971/j.issn.1000-8578.2019.18.0482.
[28] 李萍萍,刘洁,李娟,周灿*等.CRB3诱导乳腺癌他莫昔芬耐药细胞LCC2凋亡的机制研究[J].现代肿瘤医学,2019,27(13):2236-2240.DOI:10.3969/j.issn.1672-4992.2019.13.003.
[29] 李娟,李萍萍,刘洁,周灿*,刘培军等.抑癌基因LKB1与乳腺癌他莫昔芬耐药性之间的关系[J].现代肿瘤医学,2018,26(20):3184-3189.DOI:10.3969/j.issn.1672-4992.2018.20.004.
[30] 刘洁,李娟,李萍萍,周灿*,刘培军.DLG5与34βE12在乳腺癌中表达的相关性及临床意义[J].现代肿瘤医学,2018,26(20):3224-3228.DOI:10.3969/j.issn.1672-4992.2018.20.013.
[31] 李萍萍,李娟,刘洁,曹芳,苗裔,周灿,刘培军等.基于TCGA数据库分析CRB3在肾透明细胞癌(ccRCC)中的表达及其与预后的关系[J].现代肿瘤医学,2018,26(21):3428-3432.DOI:10.3969/j.issn.1672-4992.2018.21.020.
*获奖情况
1. 女性乳腺癌淋巴结转移规律及临床治疗策略的研究，2015年，陕西省科技进步奖（二等），陕西省人民政府，：2018年度中国康复医学会科学技术奖二等奖。
*联系方式
联系电话：13474012971
电子邮箱：zhoucanz2005@126.com
