尹晓然

尹晓然学 术 简 历

尹晓然医学博士 主任医师/副教授

西安交通大学第二附属医院 肿瘤科 内科专业

医工结合博士后团队导师/博士合作导师/硕士导师

哈佛大学附属麻省总医院客座副教授/访问学者

基本介绍:

专业任职:担任中国老年学与老年医学学会肿瘤康复分会委员,中国抗癌协会心理委员会委员,世界中联肿瘤外治法专委会理事,中华中医药学会名医学术研究分会委员,中国抗癌协会整合肿瘤分会青委委员。担任陕西省抗癌协会老年肿瘤青委会、多原发及不明原发肿瘤青委会副主任委员,陕西省抗癌协会肿瘤免疫诊疗、转化医学专业委员会常委,陕西省医师协会胰胆疾病专业委员会常委,陕西省抗癌协会大肠癌专业委员会药物学组副组长,陕西省抗癌协会抗癌药物、热疗专业委员会常委等。获美国整合肿瘤学会肿瘤全程康复ISO认证。

临床专长:擅长肺癌、消化道肿瘤及乳腺癌等恶性肿瘤的诊断和化疗、分子靶向治疗、免疫治疗、内分泌治疗、肿瘤康复治疗等肿瘤内科综合治疗,尤其擅长恶性肿瘤患者的免疫治疗等精准个体化诊疗以及肿瘤患者精细化全程管理,对恶性肿瘤的内科诊治有丰富的临床经验和专业的诊疗见解。《人民日报》特邀科普医学专家。

研究专长:研究方向为医工结合纳米药物精准诊疗恶性肿瘤、基于深度学习的临床大数据挖掘、以及恶性肿瘤干细胞相关研究。国际知名期刊Front. Immunol.(医学一区)等期刊客座主编,国际知名期刊Bioinformatics (计算生物学一区顶刊IF 6.9)、Genes&Diseases (分子生物学一区IF 7.2)、FPH (医学一区IF 6.5)等杂志特约审稿专家;主持并主要参与国家自然科学基金3项,主持陕西省重大攻关项目等10余项基金;发表学术论文近50篇,其中SCI收录20余篇(一作/通讯作者发表医学一区封面论文IF 11.7,药学一区顶刊IF 17.9,计算生物学一区顶刊IF 6.9;主要参与纳米科学顶刊IF 30.9);获国家实用发明专利2项,获陕西省科学技术二等奖;副主编《Barrett食管与腺癌》等专著;2022WCC、2018WGHC、2022ICBEB口头汇报;参与哈佛大学附属麻省总医院BENMD实验室合作NIH转化项目。

代表论文(一作及通讯等重要论文):

[1]Xiaoran Yin, Yanan Cui, Richard S. Kim, Wesley R. Stiles, Seung Hun Park, Haoran Wang, Li Ma, Lin Chen, Yoonji Baek, Satoshi Kashiwagi, Kai Bao, Amy Ulumben, Takeshi Fukuda, Homan Kang, and Hak Soo Choi.Image-Guided Drug Delivery of Nanotheranostics for Personalized Lung Cancer Therapy. Theranostics, 2022; 12(9):4147-4162. (SCI, IF: 11.556,医学一区,封面文章)

[2]Xiaoran Yin, Yifan Cheng, Yan Feng, Wesley R. Stiles, Seung Hun Park, Homan Kang, and Hak Soo Choi.Phototheranostics for Multifunctional Treatment of Cancerwith Fluorescence Imaging. Advanced Drug Delivery Reviews, 2022; doi:10.7150/72803. (SCI, IF: 17.873,药学一区顶刊)

[3]Lyu H, Liu E, Wu Z, Li Y, Liu Y, Yin X. scHiCPTR: unsupervised pseudotime inference through dual graph refinement for single-cell Hi-C data. Bioinformatics. 2022 Oct 7:btac670. (通讯作者, SCI, IF:6.931,数学与计算生物学一区)

[4]H. Kang, M. Shamim, X. Yin, E. Adluru, T. Fukuda, S. Yokomizo, H. Chang, S.H. Park, Y. Cui, A.J. Moy, S. Kashiwagi, M. Henary, H.S. Choi, Tumor-Associated Immune-Cell-Mediated Tumor-Targeting Mechanism with NIR-II Fluorescence Imaging, Adv Mater, 34 (2022) e2106500. (SCI, IF:30.5,纳米科学一区顶刊)

[5]Yin X#, Zhang J#, Li X,Liu D,Feng C,Liang R,Zhuang K,Cai C,Xue X,Jing F,Wang X,Wang J,Liu X,Ma H*.DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways,Int J Mol Sci, 2014, 15(7): 12422-12441. (SCI, IF: 5.923,医学一区)

[6]Yin X, Feng C, Han L, Ma Y, Jiao Y, Wang J, Jia L, Jing F, Gao X, Zhang Y, Zhang J*. Diallyl disulfide inhibits the metastasis of type Ⅱ esophageal-gastric junction adenocarcinoma cells via NF-κB and PI3K/AKT signaling pathways in vitro. Oncol Rep, 2018, 39(2): 784-794. (SCI, IF: 4.136)

[7]Yin X, Zhang R, Feng C,Zhang J,Liu D,Xu K,Wang X,Zhang S,Li Z,Liu X,Ma H*.Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21 and MEK-ERK pathways in human esophageal squamous cell carcinoma,Oncol Rep, 2014, 32(4): 1748-1756. (SCI, IF: 4.136)

[8]Zhang R, Yin X, Shi H, Wu J, Shakya P, Liu D, Zhang J*, Adiponectin Modulates Inflammatory Factors Expression Induced by Deoxycholic Acid via Reactive Oxygen Species in Esophageal Adenocarcinoma Cells, Gastroenterology, 2013, 144(5): S-675.(SCI, IF:22.68)

[9]Yin XR, Zhang M, Luo YY, Lin X, He PC, Chen LM, Cai RB, Guo GL. Induction of active antitumor immune response by myeloma idiotype protein-pulsed dendritic cells. Ai Zheng. 2005, 24(6): 657-662. Chinese. (MI)

[10]Zhang M,Yin XR,Luo YY,Lin X,Wang MC,He PC,Li J,Guo GL,Cai RH,Liu YL. In vitro anti-myeloma effects induced by myeloma idiotype-protein pulsed dendritic cell vaccine, Zhonghua Xue Ye Xue Za Zhi. 2005, 26(10): 593-597. Chinese. (MI, tutor first)

重要特邀报告:

[1]Xiaoran Yin, “Image-Guided Theranostic Nanomedicine for Precise Combination Therapy of Lung Cancer”, World Cancer Congress, Geneva, Switzerland, Oct. 2022(世界癌症大会2022WCC,由UICC国际抗癌联盟主办的全球顶级会议,口头报告).

[2]Xiaoran Yin, “LGR5+/CD44+ cells endow cancer stemness and EMT property through WNT/TGF-β crosstalk predicting poor prognosis in gastric adenocarcinoma”, the 11th International Conference on Biomedical Engineering and Biotechnology (ICBEB 2022), Shenzhen, China, Nov. 2022. (第11届生物医学工程与生物技术国际学术会议2022ICBEB,特邀口头报告).

[3]Xiaoran Yin, “Barrett’s esophagus and its correlation with gastroesophageal reflux in Chinese”, World Gastroenterology & Hepatology Conference, Rome, Italy, Sep. 2018 (Invited Talk, 20 minutes)(世界胃肠病学与肝病会议2018WGHC,特邀口头报告).

编委会任职:

[1]国际知名期刊Frontiers in Immunology (IF 8.786/医学一区) /Frontiers in Oncology客座主编,主编肿瘤免疫特刊国际阅读量达万余人次。

[2]国际知名期刊FPH (医学一区)、Bioinformatics (数学与计算生物学一区)、JPP、FBL、IJMM特约审稿专家.

联系方式:

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