王 珂

个人及工作简历

受教育经历:

2010/11-2011/11 美国波士顿大学,医学院,访问学者,导师Luo Zhi-jun

2004/09-2007/11,西安交通大学,医学院,研究生/博士,导师马清涌

2002/09-2004/07,西安交通大学,医学院,研究生/硕士,导师陈武科

1997/09-2002/07,西安交通大学,医学院,本科/学士

研究工作经历(按时间倒排序):

2007/11-目前,西安交通大学,第一附属医院,副主任医师

*研究领域(方向)

乳腺癌综合治疗的基础与临床研究

*科研项目

1.陕西省重点研发计划,2020SF-039,《Thailanstatin逆转HER2阳性乳腺癌赫赛汀耐药机制研究》,2020/1-2021/12,8.0万元,在研,主持。

2.陕西省自然科学基金,2015JM8399,《Basal-like型乳腺癌细胞高脑转移能力相关基因的研究》,2015/1-2016/12,3.0万元,已结题,主持。

3. 陕西省科学技术研究发展计划项目,2014K11-01-01-06,《青藤碱抑制Basal-like型人乳腺癌细胞系MDA-MB-231侵袭转移的作用及机制研究》,2014/1-2016/1,7.0万元,已结题,主持。

4. 陕西省科学技术研究发展计划项目,2009K12-01,《Basal-like型乳腺癌细胞高脑转移能力相关基因的研究》,2009/7-2013/1,10.0万元,已结题,主持。

5. 国家自然科学基金面上项目,81173613,《青藤碱对乳腺癌MDA-MB-231细胞的作用及机制研究》,2012/01-2015/12,58万元,已结题,参加。

*学术集科研成果、专利、论文

一、第一作者论文

(1) Wang K, Ren Y, Liu Y, Zhang J, He J*. Tumor necrosis factor (TNF)-α-induced protein 8-like-2 (TIPE2) inhibits proliferation and tumorigenesis in breast cancer cells [J]. Oncology Research, 2017, 25: 55-63.

(2) Wang K, Ren Y, Liu Y, Zhang J, He J*. miR-4262 promotes proliferation and invasion of human breast cancer cells through directly targeting KLF6 and KLF15 [J]. Oncology Research, 2017, 25: 277-283.

(3) Wang K, Ren Y, He J*. Cavity shaving plus lumpectomy versus lumpectomy alone for patients with breast cancer undergoing breast-conserving surgery: a systematic review and meta-analysis [J]. Plos One, 2017, 12(1): e0168705.

(4) Wang K#, Ren Y#, Li H, Zheng K, Jiang J, Zou T, Ma B, Li H, Liu Q, Ou J, Wang L, Wei W, He J*, Ren G*. Comparison of clinicopathological features and treatments between young (40 years) and older (40 years) female breast cancer patients in west China: a retrospective, epidemiological, multicenter, case only study [J]. Plos One, 2016, 11(3): e0152312.

(5) Wang K#, Ren Y#, Huang R, He JJ, Feng WL, Kong YN, Xu F, Zhao L, Song QK, Li J, Zhang BN, Fan JH, Xie XM*, Zheng S*, Qiao YL. Application of intraoperative frozen section examination in the management of female breast cancer in China: a nationwide, multicenter 10-year epidemiological study [J]. World J Surg Onco, 2014, 12:225-232.

(6) Wang K#, Li X#, Zhou C, Ren Y, Wang X, He J*. Identification of socio-economic factors influencing tumor presentation and treatment options in Chinese breast cancer patients [J]. APJCP, 2013, 14267-274.

(7) Wang K, Xie S, Ren Y, Xia H, Zhang X, He J*. Establishment of a bioluminescent MDA-MB-231 cell line for human triple-negative breast cancer research [J]. Oncology Reports, 2012, 27: 1981-1989.

(8) 王珂,周灿,谢四梅,任予,王现兵,何建军*.患者职业对乳腺癌临床病理特征及治疗模式的影响{J}.西安交通大学学报医学版, 2013, 34(2): 218-223.

(9) 王珂,谢四梅,何建军*,任予,夏海滨,张新伟. 用于活体成像的人三阴性乳腺癌MDA-MB-231细胞系的构建[J]. 南方医科大学学报, 2011, 31(11): 1812-1818.

(10) 王珂, 任予, 何建军*, 张云锋, 陈武科, 马清涌. 人乳腺癌组织中Wnt/β-catenin信号传导通路的异常表达与Her2阳性表达间的关系[J]. 西安交通大学学报医学版, 2009, 30(5): 587-591.

(11) Wang K, Ma Q*, Ren Y, He J, Zhang Y, Zhang Y, Chen W. Geldanamycin destablizes HER2 tyrosine kinase and suppresses Wnt/β-Catenin signaling in HER2 overexpressing human breast cancer cells[J]. Oncology Reports, 2007, 17(1): 89-97.

(12) 王珂, 马清涌*, 任予, 何建军, 张云锋, 陈武科. Geldanamycin inhibits proliferation and motility of HER2/neu-overexpressing SKBr3 breast cancer cells[J]. 南方医科大学学报, 2007, 27(10): 1480-1484.

(13) 王珂, 任予, 陈武科*. 恶性肿瘤的放射性粒子植入治疗[J]. 现代肿瘤医学, 2004 12: 485-487.

二、通讯作者论文

(1) Zhang J, Xiao L, Pu S, Liu Y, He J, Wang K*. Can we reliably identify the pathological outcomes of neoadjuvant chemotherapy in patients with breast cancer? Development and validation of a logistic regression nomogram based on preoperative factors. Ann Surg Oncol, 2020, Online ahead of print.

(2) Wang B, Zhu L, He C, Tai M, Zhou C, Ge G, Zhang H, He J, Wang K*. Growth pattern can be used as a new characteristic to predict malignancy in breast cancer. Breast Cancer, 2020, 27: 445-455.

(3) Wang B, Zhu L, Jiang S, Zhao L, Zhou Y, Niu L, Yan Y, Wang K*. Association between body mass index and clinical characteristics, as well as with management, in Chinese patients with breast cancer. Journal of International Medical Research, 2020, 48: 1-15.

(4) Zhang H, Xie P, Li Z, Huang R, Feng W, Kong Y, Xu F, Zhao L, Song Q, Li J, Zhang B, Fan J, Qiao Y, Xie X, Zheng S, He J*, Wang K*. A Nomogram for Predicting the HER2 Status in Female Patients with Breast Cancer in China: A Nationwide, Multicenter, 10-year Epidemiological Study[J]. Diagnostic Pathology, 2019, 14:35.

(5) Liu Y, Zhang J, Huang R, Feng W, Kong Y, Xu F, Zhao L, Song Q, Li J, Zhang B, Fan J, Qiao Y, Xie X, Zheng S, He J*, Wang K*. Influence of occupation and education level on Breast Cancer Stage at Diagnosis, and Treatment Options in ChinaA nationwide, multicenter 10-year epidemiological study [J]. Medicine, 2017, 96: 15.

(6) Zhang J, Li X, Huang R, Feng W, Kong Y, Xu F, Zhao L, Song Q, Li J, Zhang B, Fan J, Qiao Y, Xie X, Zheng S, He J*, Wang K*. A nomogram to predict the probability of axillary lymph node metastasis in female patients with breast cancer in China: A nationwide, multicenter, 10-year epidemiological study [J]. Oncotarget, 2017, 8(21): 35311-35325.

(7) Li X, Li P, Liu C, Ren Y, Tang X, Wang K*, He J*. Sinomenine hydrochloride inhibits breast cancer metastasis by attenuating inflammation-related epithelial-mesenchymal transition and cancer stemness [J]. Oncotarget, 2017, 8(8): 13560-13574.

(8) 孙刚, 王珂*. 月经初潮年龄对中国女性乳腺癌临床病理特征及分子表型的影响. 现代肿瘤医学, 2015, 23(24): 3592-3595.

*获奖情况

(1)王珂(1/7),Geldanamycin destablizes HER2 tyrosine kinase and suppresses Wnt/β-Catenin signaling in HER2 overexpressing human breast cancer cells,陕西省政府,陕西省自然科学优秀论文奖,三等奖,2010

王珂,马清涌,任予,何建军,张勇,张云锋,陈武科)

2)王珂(2/9),女性乳腺癌淋巴结转移规律及临床治疗策略的研究,陕西省科技厅,陕西省科学技术奖,二等奖,2015

(任予,王珂,周灿,牛利刚,张伟,闫宇,周瑜辉,李斌,李娟)


*社会任职

(1)中华医学会肿瘤分会乳腺肿瘤青年学组委员

(2)中国性学会乳腺疾病分会常委

(3)中国医药教育协会乳腺专业委员会委员

(4)陕西省抗癌协会青年工作委员会常务副主任委员

(5)陕西省抗癌协会外科肿瘤专业委员会常委兼秘书

(6)陕西省保健协会乳腺保健专业委员会常委


*联系方式

联系电话:18991232545

电子邮箱:979915080@qq.com


上一篇:王淑红
下一篇:张勇

地址:陕西省西安市咸宁西路28号 邮编:710049
版权所有:西安交通大学 站点建设与维护: 网络信息中心 陕ICP备06008037号