王亚蓉



*个人及工作简历

教育背景

1991.09 - 1996.06 西安医科大学大学临床医疗专业学士

1997.09 - 2000.06 西安交通大学影像医学与核医学专业硕士

2001.08 - 2005.06 第四军医大学影像医学与核医学专业博士

2013.11-2014.10 美国佛罗里达大学McKnight 脑研究所访问学者

工作经历:

1996.08 - 1997.08 西安医科大学第一附属医院放射科住院医师,助教

2000.06 - 2001.06 西安交大第一医院影像中心住院医师,助教

2001.06 - 2002.08 西安交大第一医院影像中心主治医师,讲师

2002.09 - 2013.08 第四军医大学第二附属医院放射诊断科主治医师,讲师

2013.08 - 2016.012 第四军医大学第二附属医院放射诊断科副主任医师,副教授

2017.01- 西安交大第一医院影像中心副主任医师,副教授

 

*研究领域(方向)

临床主要从事中枢神经系统疾病影像诊断的研究。

科研研究方向为人类功能性脑疾病的影像学诊断,以及药物依赖的神经物质基础的fMRI 研究。

*科研项目


主持的科研项目

1 国家自然科学基金面上项目

多巴胺受体D2 基因型调节美沙酮维持治疗的海洛因成瘾者大脑神经活动的fMRI研究No.81471648 2015.01-2018.12 73 万元

2 国家自然科学基金面上项目

多巴胺受体激动剂对不同DRD2 基因型大脑奖赏系统作用的功能影像学研究No.81071143 2011.01-2013.12 30 万元

3 陕西省科技攻关项目

多巴胺受体D2 基因型调节美沙酮维持治疗海洛因成瘾者大脑神经活动fMRI 研究2015SF0022015.01-2016.12 5 万元

4 陕西省科技攻关项目

美沙酮对大脑渴求反应神经底物的结构和功能影响的MRI 研究No.2010K16-03 2010.01-2012.12 10 万元

 

参与的科研项目

  1. 国家自然科学基金面上项目

    “MMT 时间与计量效应对海洛因成瘾者大脑影响的MRI 研究

    810711042 2011.01-2013.12

  2. 国家自然科学基金面上项目

    伏隔核缺失态下大脑奖赏环路渴求功能的MRI 研究

    308706852009.01-2011.12

  3. 国家自然科学基金面上项目

    “MMT 海洛因成瘾者奖赏系统改变与复吸关系的多模态MRI 研究813715322013.01-2016.12

  4. 国家自然科学基金青年项目

    强制戒断时间效应对海洛因成瘾者渴求影响的纵向研究

    812010812012.01-2014.12

  5. 军队医药卫生科研基金

    下肢火器伤瞬时远达效应对心肺功能及结构影响VCT 研究

    ( 06MA207) 2006-2010

  6. 国家重点研发计划-全数字化精准定量高场超导磁共振系统研制项目 所属专项:数字诊疗装备研发

    高场磁共振系统及新型序列的临床验证 2017FYC010870420177-202012

 

*学术集科研成果、专利、论文

论文

  1. Y.Li, Q.Li, W.Chen, J.Hu, F.Liu, Y.Wei, X.Zhu, J.Liu, J.Ye, J.Shi, H.Wang, Y. Wang, W. Wang. The polymorphism of dopamine D2 receptor TaqIA gene is associated with brain response to drug cues in male heroin-dependent individuals during methadone maintenance treatment. Drug Alcohol Depend. 2019 May 1;198:150-157. (corresponding author)

  2. Li Q, Liu J, Wang W, Wang Y, Li W, Chen J, Zhu J, Yan X, Li Y, Li Z, Ye J, Wang W. Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men. J Psychiatry Neurosci. 2018 Jan;43(1):48-57.

  3. Chang H, Li W, Li Q, Chen J, Zhu J, Ye J, Liu J, Li Z1, Li Y, Shi M, Wang Y, Wang W. Regional homogeneity changes between heroin relapse and non-relapse patients under methadone maintenance treatment: a resting-state fMRI study.BMC Neurol. 2016 Aug 18;16(1):145 (corresponding author)

  4. Li W, Zhu J, Li Q, Ye J, Chen J, Liu J, Li Z, Li Y, Yan X, Wang Y, Wang W. Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.Brain Behav. 2016 24;6(2):e00436. (corresponding author)

  5. W. Li, Q. Li, D. Wang, W. Xiao, K. Liu, L. Shi, J. Zhu, Y. Li, X. Yan, J. Chen, J. Ye,Z. Li, Y. Wang, W. Wang, Dysfunctional Default Mode Network in Methadone Treated Patients Who Have a Higher Heroin Relapse Risk, Sci Rep 5 (2015) 15181.(corresponding author)

  6. Qiang Li, Zhe Li, Wei Li, Yi Zhang, Yarong Wang, Jia Zhu, Jiajie Chen, Yongbin Li, Xuejao Yan, Jianjun Ye, Linbin Li, Wei Wang, Yijun Liu. Disrupted default mode network and basal craving in make heroin-dependent individuals: a resting-state fMRI study. Journal of Clinical Psychiatry. 2016, doi: 10.4088/JCP.15m09965.

  7. Q. Li, W. Li, H. Wang, Y. Wang, Y. Zhang, J. Zhu, Y. Zheng, D. Zhang, L. Wang, Y. Li, X. Yan, H. Chang, M. Fan, Z. Li, J. Tian, M.S. Gold, W. Wang, Y. Liu, Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study, Addict Biol 20 (2015) 968-978.

  8. Y. Wang, H. Wang, W. Li, J. Zhu, M.S. Gold, D. Zhang, L. Wang, Y. Li, X. Yan, J.Cheng, Q. Li, W. Wang, Reduced responses to heroin-cue-induced craving in the dorsal striatum: effects of long-term methadone maintenance treatment, Neurosci Lett 581 (2014) 120-124.

  9. Y. Wang, J. Zhu, Q. Li, W. Li, N. Wu, Y. Zheng, H. Chang, J. Chen, W. Wang, Altered fronto-striatal and fronto-cerebellar circuits in heroin-dependent individuals: a resting-state FMRI study, PLoS One 8 (2013) e58098.

  10. Q. Li, Y. Wang, Y. Zhang, W. Li, J. Zhu, Y. Zheng, J. Chen, L. Zhao, Z. Zhou, Y. Liu, W. Wang, J. Tian, Assessing cue-induced brain response as a function of abstinence duration in heroin-dependent individuals: an event-related fMRI study, PLoS One 8 (2013) e62911.(co-first)

  11. Y. Wang, J. Zhu, L. Chen, Y. Liu, Q. Li, W. Yang, W. Li, L. Zhao, M.S. Gold, J. Sun, W Wang, The effect of nucleus accumbens lesions on appetite, sexual function, and nicotine dependence in recovering heroin addicts. Translational Neuroscience. 2013, 4(4): 419-428

  12. W. Li, Q. Li, J. Zhu, Y. Qin, Y. Zheng, H. Chang, D. Zhang, H. Wang, L. Wang, Y. Wang, W. Wang, White matter impairment in chronic heroin dependence: a quantitative DTI study, Brain Res 1531 (2013) 58-64. (corresponding author)

  13. R.G. Fu, R.L. Xue, J. Wang, L.Q. Ma, J.R. Lv, L. Wang, G.L. Yao, H. Ge, Z. Chen, Z.Y. Duan, Y. Wang, Uremic anorexia and ghrelin expression in the amygdala, Neurosci Lett 527 (2012) 50-54. (corresponding author)

  14. J. Sun, Y. Wang, J. Yang, D. Du, Z. Li, J. Wei, A. Yang, Long-term and stable correction of uremic anemia by intramuscular injection of plasmids containing hypoxia-regulated system of erythropoietin expression, Exp Mol Med 44 (2012) 674-683. (co-first)

  15. Y. Wang, W. Li, Q. Li, W. Yang, J. Zhu, W. Wang, White matter impairment in heroin addicts undergoing methadone maintenance treatment and prolonged abstinence: a preliminary DTI study, Neurosci Lett 494 (2011) 49-53.

  16. W. Ya-Rong, W. Wei, Z. Jia, Imaging features of aggressive fibromatosis in psoas muscle, JBR-BTR 94 (2011) 283-286.

  17. W. Wang, Y.R. Wang, W. Qin, K. Yuan, J. Tian, Q. Li, L.Y. Yang, L. Lu, Y.M. Guo, Changes in functional connectivity of ventral anterior cingulate cortex in heroin abusers, Chin Med J (Engl) 123 (2010) 1582-1588.(co-first)

  18. Q. Li, Y. Wang, Y. Zhang, W. Li, W. Yang, J. Zhu, N. Wu, H. Chang, Y. Zheng, W. Qin, L. Zhao, K. Yuan, J. Liu, W. Wang, J. Tian, Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: an event-related fMRI study, Brain Res 1469 (2012) 63-72.

  19. W. Li, Q. Li, Y. Wang, J. Zhu, J. Ye, X. Yan, Y. Li, J. Chen, J. Liu, Z. Li, W.Wang, Y. Liu, Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study, Sci Rep 6 (2016) 19662.

  20. J. Yang, W. Wang, Y.R. Wang, G. Niu, C.W. Jin, E.X. Wu, A free-breathing non-contrast-enhanced pulmonary magnetic resonance angiography at 3 Tesla, Chin Med J (Engl) 122 (2009) 2111-2116.

  21. K. Blum, Y. Liu, W. Wang, Y. Wang, Y. Zhang, M. Oscar-Berman, A. Smolen, M. Febo, D. Han, T. Simpatico, F.J. Cronje, Z. Demetrovics, M.S. Gold, rsfMRI effects of KB220Z on neural pathways in reward circuitry of abstinent genotyped heroin addicts, Postgrad Med 127 (2015) 232-241.

  22. J. Liu, J. Liang, W. Qin, J. Tian, K. Yuan, L. Bai, Y. Zhang, W. Wang, Y. Wang, Q. Li, L. Zhao, L. Lu, K.M. von Deneen, Y. Liu, M.S. Gold, Dysfunctional connectivity patterns in chronic heroin users: an fMRI study, Neurosci Lett 460 (2009) 72-77.

  23. K. Yuan, W. Qin, M. Dong, J. Liu, P. Liu, Y. Zhang, J. Sun, W. Wang, Y. Wang, Q. Li, W. Yang, J. Tian, Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals, Neurosci Lett 475 (2010) 20-24.

  24. K. Yuan, W. Qin, J. Liu, Q. Guo, M. Dong, J. Sun, Y. Zhang, P. Liu, W. Wang, Y. Wang, Q. Li, W. Yang, K.M. von Deneen, M.S. Gold, Y. Liu, J. Tian, Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals, Neurosci Lett 477 (2010) 37-42.

     

    获得教学奖项:

    1. 陕西省高教教学成果二等奖

    基于医学影像学智能信息化知识构建平台的创新型实践性教学体系的建立和实践” 2012 年第二完成人

    2. 军队教学成果优秀奖

    基于T-PACS 平台和分段式教学模式的实践能力提升型全程互反馈医学影像学教学体系 2012 年第三完成人

    3. 陕西省精品教学团队

    《医学影像学》2014 年第二完成人

     

    获得科技奖项:

    1 陕西省科技进步

    海洛因成瘾脑结构与功能演变规律研究及疗效评价体系构建

    2016 年第二完成人

     

    2 军队科技进步二等奖

    火器伤致多器官瞬时远达效应的CT、病理、生理生化的研究

    2008 年第三完成人

    联系方式

      联系电话:13572415690

      电子邮箱:wangyr9t@xjtu.edu.cn

      个人主页:

      联系地址:西安交大一附院医学影像科

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