西安交通大学生命科学与技术学院教授，博士生导师；主要研究方向为生物化学反应与分析技术、基于多信息融合的生物光谱传感和生物化学反应与分离工程。主讲课程为《生物化学》、《生物分离工程》和《生物过程工程与技术》。主持国家自然科学基金、国家留学人员科技活动择优资助项目、陕西省自然科学基金、高等学校基本科研及西安交通大学校内基金等项目；作为骨干成员参与国家863项目、国家自然科学基金目多项。在国际、国内高水平期刊上发表相关科研论文120余篇，申请发明专利5项，已授权4项。

工作经历：

(1) 2017-01 至 今, 西安交通大学, 生命科学与技术学院, 教授

(2) 2008-07 至 2016-12, 西安交通大学, 生命科学与技术学院, 副教授

(3) 2013-07 至 2014-07, 美国伊利诺伊大学香槟分校, 化学系, 无

(4) 2004-03 至 2008-06, 西安交通大学, 生命科学与技术学院, 讲师

研究方向：

1. 多形貌贵金属纳米颗粒的制备及光谱性质调控

2. 基于纳米金的生物光学探针制备及应用

3. 基于多信息融合的生物光谱传感

4. 生物化学反应与分析技术

主要项目：

1. 国家自然科学基金委员会, 面上项目, 62275214, 针对胰腺癌早期诊断的纳米异质二聚体超痕量高灵敏拉曼探针, 2023-01-01 至 2026-12-31, 59万元, 在研, 参与

2. 陕西省科技厅, 陕西省重点研发计划高校联合项目-重点项目, 2020GXLH-Z-003, 针对重大疾病精准诊断的实时荧光/拉曼双模检测系统研究, 2020-01 至 2023-12, 200万元, 在研, 参与

3. 陕西省科技厅, 陕西省自然科学基金, 2021JM-024, 基于金银双金属纳米星的荧光/拉曼双模多组分肿瘤免疫检测, 2021-01 至 2022-12-31, 4万元, 结题, 主持

获奖及授权专利：

(1) 李剑君(3/5); 低对称性纳米结构多信息光谱特性调控及其在生化精准检测中的应用, 陕西省人民政府, 自然科学, 省部一等奖, 2021(赵军武; 朱键; 李剑君; 翁国军; 赵婧) 

(2) 李剑君(3/4); 核壳型贵金属纳米颗粒的等离体子光学特性及其生物传感机理研究, 陕西省教育厅, 自然科学, 其他, 2015(朱键; 赵军武; 李剑君; 黄丽清) 

(3) 李剑君(3/9); 低对称性纳米结构的多信息光谱特性调控及其在特异性生化精准检测中的应用, 陕西省教育厅, 自然科学, 其他, 2020(赵军武; 朱键; 李剑君; 翁国军; 赵婧; 张帆; 邢廷洋; 张春红; 祁英) 

(4) 翁国军; 冯瑶; 赵婧; 李剑君; 朱键; 赵军武 ; 一种柔性SERS基底及其制备方法和双氧水SERS光谱检测的应用, 2021-3-2, 中国, ZL201811615951.4 

(5) 李剑君; 李韬; 朱键; 赵军武 ; 一种碱性条件下过氧化氢诱导的金纳米棒的制备方法, 2016-04-27,中国, ZL201310158683.9 

(6) 李剑君; 翁国军; 朱键; 赵军武 ; 一种纳米金免疫探针的制备方法, 2013-12-11, 中国,ZL201010617002.7 

(7) 刘钊; 李剑君; 朱键; 赵军武 ; 一种基于生物矿化原理的超微量蛋白质定量检测方法, 2013-07-10,中国, ZL201110089936.2 

(8) 赵婧; 吴晨; 李剑君; 翁国军; 朱键; 赵军武 ; 一种运用核壳结构纳米星检测肝癌肿瘤标志物AFP的方法, 2019-3-11, 中国, CN201910181945.0 

近5年发表代表性论文：

[1] Wu F-N, Zhu J, Weng G-J, Li J-J, Chen X-W, Zhao J-W. Electron transfer-based norepinephrine detection with high sensitivity regulated by polyethyleneimine molecular weight [J]. Sensors and Actuators B: Chemical, 2023, 379: 133297.

[2] Wu G-f, Zhu J, Weng G-j, Cai H-y, Li J-j, Zhao J-w. The structure and plasmonic properties regulation of Au@Ag core-shell nanostructures with Au triangular nanoprisms as the core mediated by halide [J]. Journal of Alloys and Compounds, 2023, 944: 169245.

[3] Liu Y-l, Zhu J, Weng G-j, Li J-j, Zhao J-w. Simultaneous determination of three food contaminants in shrimp paste by hollow porous pentagonal Au/Ag alloy nanotubes with excellent SERS activity [J]. Sensors and Actuators B: Chemical, 2022, 373: 132766.

[4] Wu F-N, Zhu J, Weng G-J, Li J-J, Zhao J-W. Gold nanocluster composites: preparation strategies, optical and catalytic properties, and applications [J]. Journal of Materials Chemistry C, 2022, 10(40): 14812-14833.

[5] He Z, Zhu J, Li X, Weng G-J, Li J-J, Zhao J-W. Surface etching-dependent geometry tailoring and multi-spectral information of Au@AuAg yolk-shell nanostructure with asymmetrical pyramidal core: The application in Co2+ determination [J]. Journal of Colloid and Interface Science, 2022, 625: 340-353.

[6] Li J-y, Zhu J, Weng G-j, Li J-j, Zhao J-w. Multiplex Sensing Based on Plasmonic Optics of Noble Metallic Nanostructures [J]. Critical Reviews in Analytical Chemistry, 2022: 1-13.

[7] Weng G, Shen X, Li J, Wang J, Zhu J, Zhao J. A plasmonic ELISA for multi-colorimetric sensing of C-reactive protein by using shell dependent etching of Ag coated Au nanobipyramids [J]. Analytica Chimica Acta, 2022, 1221: 340129.

[8] Liu Y, Zhu J, Weng G, Li J, Zhao J. Selective controlling transverse plasmon spectrum of pentagonal gold nanotube：from visible to near-infrared region [J]. Nanotechnology, 2021, 32(44): 445202.

[9] Wu G F, Zhu J, Weng G J, Li J J, Zhao J W. Heterodimers of metal nanoparticles: synthesis, properties, and biological applications [J]. Microchimica Acta, 2021, 188(10): 21.

[10] Yang Y, Zhu J, Weng G-j, Li J-j, Zhao J-w. Gold nanoring core-shell satellites with abundant built-in hotspots and great analyte penetration: An immunoassay platform for the SERS/fluorescence-based detection of carcinoembryonic antigen [J]. Chemical Engineering Journal, 2021, 409: 128173.

[11] Zhu J, Meng L-n, Weng G-j, Li J-j, Zhao J-w. Tuning quadruple surface plasmon resonance in gold nanoellipsoid with platinum coating: from ultraviolet to near infrared [J]. Applied Physics A, 2021, 127(8): 591.

[12] Wu F-N, Zhu J, Weng G-J, Li J-J, Zhao J-W. Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine [J]. ACS Applied Nano Materials, 2021, 4(12): 13501-13509.

[13] Yang Y, Zhao J, Weng G-j, Li J-j, Zhu J, Zhao J-w. Fine-tunable fluorescence quenching properties of core-satellite assemblies of gold nanorod-nanosphere: Application in sensitive detection of Hg2+ [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 228: 117776.

[14] Weng G, Feng Y, Zhao J, Li J, Zhu J, Zhao J. Sensitive detection of choline in infant formulas by SERS marker transformation occurring on a filter-based flexible substrate [J]. Sensors and Actuators B: Chemical, 2020, 308: 127754.

[15] He Z, Zhu J, Weng G-J, Li J-J, Zhao J-W. Detection of ferrous ion by etching-based multi-colorimetric sensing of gold nanobipyramids [J]. Nanotechnology, 2020, 31(33): 335505.

[16] Liu Y-l, Zhu J, Weng G-j, Li J-j, Zhao J-w. Gold nanotubes: synthesis, properties and biomedical applications [J]. Microchimica Acta, 2020, 187(11): 612.

[17] Li Y-l, Zhu J, Weng G-j, Li J-j, Xing T-y, Zhao J-w. “Magic mitt”: Morphologically controllable AuAg@AuAg yolk-shell nanostars with better plasmonic optical properties [J]. Journal of Alloys and Compounds, 2020, 844: 156134.

[18] Chen J-K, Zhao S-M, Zhu J, Li J-J, Zhao J-W. Colorimetric determination and recycling of Hg2+ based on etching-induced morphology transformation from hollow AuAg nanocages to nanoboxes [J]. Journal of Alloys and Compounds, 2020, 828: 154392.

[19] Weng G, Zhao X, Zhao J, Li J, Zhu J, Zhao J. Nanoplasmonic sensing of NADH by inhibiting the oxidative etching of gold nanorods [J]. Sensors and Actuators B: Chemical, 2019, 299: 126982.

[20] Zhu J, Du H-f, Zhang Q, Zhao J, Weng G-j, Li J-j, Zhao J-w. SERS detection of glucose using graphene-oxide-wrapped gold nanobones with silver coating [J]. Journal of Materials Chemistry C, 2019, 7(11): 3322-3334.

[21] Zhao J, Wu C, Zhai L, Shi X, Li X, Weng G-j, Zhu J, Li J, Zhao J-w. A SERS-based immunoassay for the detection of α-fetoprotein using AuNS@Ag@SiO₂ core-shell nanostars [J]. Journal of Materials Chemistry C, 2019, 7(27): 8432-8441

[22] Qi Y, Xing T-y, Zhao J, Weng G-j, Li J-j, Zhu J, Zhao J-w. Tuning the surface enhanced Raman scattering performance of anisotropic Au core−Ag shell hetero-nanostructure: The effect of core geometry [J]. Journal of Alloys and Compounds, 2019, 776: 934-947.

[23] Weng G, Feng Y, Zhao J, Li J, Zhu J, Zhao J. Size dependent SERS activity of Ag triangular nanoplates on different substrates: Glass vs paper [J]. Applied Surface Science, 2019, 478: 275-283.

[24] Yang Y, Zhu J, Zhao J, Weng G-J, Li J-j, Zhao J-W. Growth of spherical gold satellites on the surface of Au@Ag@SiO₂ core-shell nanostructures used for an ultrasensitive SERS immunoassay of alpha-fetoprotein [J]. ACS Applied Materials & Interfaces, 2019, 11(3): 3617–3626.

[25] Zhu J, Zhao B-z, Qi Y, Li J-J, Li X, Zhao J-W. Colorimetric determination of Hg(II) by combining the etching and aggregation effect of cysteine-modified Au-Ag core-shell nanorods [J]. Sensors and Actuators B: Chemical, 2018, 255(Part 3): 2927-2935.

[26] Zhang F, Wu N, Zhu J, Zhao J, Weng G-j, Li J-j, Zhao J-w. Au@AuAg yolk-shell triangular nanoplates with controlled interior gap for the improved surface-enhanced Raman scattering of rhodamine 6G [J]. Sensors and Actuators B: Chemical, 2018, 271: 174-182.

[27] Qi Y, Zhao J, Weng G, Li J, Zhu J, Zhao J. Modification-free colorimetric and visual detection of Hg²⁺ based on the etching from core-shell structural Au-Ag nanorods to nanorices [J]. Sensors and Actuators B: Chemical, 2018, 267: 181-190.

[28] Xing T-Y, Zhao J, Weng G-J, Li J-J, Zhu J, Zhao J-W. Synthesis of dual-functional Ag/Au nanoparticles based on the decreased cavitating rate under alkaline conditions and the colorimetric detection of mercury(ii) and lead(ii) [J]. Journal of Materials Chemistry C, 2018, 6(28): 7557-7567.

[29] Qi Y, Zhao J, Weng G-j, Li J-j, Li X, Zhu J, Zhao J-w. A colorimetric/SERS dual-mode sensing method for the detection of mercury(ii) based on rhodanine-stabilized gold nanobipyramids [J]. Journal of Materials Chemistry C, 2018, 6(45): 12283-12293.

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