西安交通大学生命科学与技术学院二级教授，博士生导师；享受国务院特殊津贴专家，享受陕西省三秦人才津贴专家，生物医学工程陕西省重点实验室主任。担任中国生物医学工程学会/生物传感技术分会委员，陕西省生物医学工程学会副理事长；传感器专业委员会主任委员。研究方向为纳米生物材料与器件、生物光谱传感技术、医学信号检测与传感器。近年来主持承担了国家高技术研究发展计划项目（863），国家自然基金项目、陕西省重点研发计划项目、其他省部级项目等数个科研项目的研究；在国内外核心学术期刊上发表SCI论文180余篇，其中中科院分区一二区论文120余篇，授权专利4项、先后获2020年陕西省科学技术一等奖（自然科学，排名第1）、2016河南省科学技术二等奖等（排名第2）、2020/2015年陕西省高等学校科学技术奖一等奖（排名第1/排名第2），在生物医学光谱传感领域和光学检测仪器研究方面具有丰富的经验和深厚的基础。

工作经历：

(1) 2006-7至现在, 西安交通大学, 生命科学与技术学院, 教授

(2) 1999-6至2006-6, 西安交通大学, 理学院, 教授

(3) 1994-1至1999-5, 西安交通大学, 理学院, 副教授

(4) 1989-1至1993-12, 西安交通大学, 理学院, 讲师

(5) 1983-7至1988-12, 西安交通大学, 理学院, 助教

研究方向：

1. 纳米生物材料与器件

2. 医学信号检测与传感器

3. 光学功能材料

4. 生物光谱传感技术

主持的主要项目：

1. 国家自然科学基金委员会, 面上项目, 62275214, 针对胰腺癌早期诊断的纳米异质二聚体超痕量高灵敏拉曼探针, 2023-01-01 至 2026-12-31, 59万元, 在研, 主持

2. 陕西省科技厅, 陕西省重点研发计划高校联合项目-重点项目, 2020GXLH-Z-003, 针对重大疾病精准诊断的实时荧光/拉曼双模检测系统研究, 2020-01 至 2023-12, 200万元, 在研, 主持

3. 国家自然科学基金委员会, 面上项目, 61675162, 一种新型异质结卫星结构超荧光增强生物免疫探针及检测薄膜, 2017-01-01 至 2020-12-31, 60万元, 结题, 主持

4. 国家自然科学基金委员会，面上项目，61178075，以超痕量肿瘤标志物检测为目标的长碳链抗体共价偶联纳米金生物荧光探针，2011-01至2015-12，65万元，已结题，主持

5. 国家自然科学基金委员会，面上项目，60477034，纳米点薄膜电子俘获光存储材料的研究，2005-01至2007-12，24万元，已结题，主持

6. 科技部, “863计划”项目, 2009AA04Z314, 面向肝癌疾病早期诊断的微纳生物光学传感器与系统研发, 2009-04 至 2011-03, 74万元, 结题, 主持

获奖及授权专利：

(1) 赵军武(1/5); 低对称性纳米结构多信息光谱特性调控及其在生化精准检测中的应用, 陕西省人民政府, 自然科学, 省部一等奖, 2021(赵军武; 朱键; 李剑君; 翁国军; 赵婧)

(2) 赵军武(1/9); 低对称性纳米结构的多信息光谱特性调控及其在特异性生化精准检测中的应用（一等奖）, 陕西省教育厅, 自然科学, 其他, 2020(赵军武; 朱键; 李剑君; 翁国军; 赵婧; 张帆; 邢廷洋; 张春红; 祁英)

(3) 赵军武(2/4); 核壳型贵金属纳米颗粒的等离体子光学特性及其生物传感机理研究（一等奖）, 陕西省教育厅, 自然科学, 其他, 2015(朱键; 赵军武; 李剑君; 黄丽清) 

(4) 赵军武(3/8); 基于智能算法的基因多态性判别及生物信息学分析, 河南省人民政府, 科技进步, 省部二等奖, 2016(陈传亮; 张建华; 赵军武; 余冬; 尹咪咪; 刘旭丹; 刘静; 张宁) 

(5) 翁国军; 冯瑶; 赵婧; 李剑君; 朱键; 赵军武 ; 一种柔性SERS基底及其制备方法和双氧水SERS光谱检测的应用, 2020-03-02, 中国, ZL201811615951.4

(6) 李剑君; 李韬; 朱键; 赵军武 ; 一种碱性条件下过氧化氢诱导的金纳米棒的制备方法, 2016-02-25,中国, ZL201310158683.9

(7) 李剑君; 翁国军; 朱键; 赵军武 ; 一种纳米金免疫探针的制备方法, 2013-12-11, 中国,ZL201010617002.7

(8) 刘钊; 李剑君; 朱键; 赵军武 ; 一种基于生物矿化原理的超微量蛋白质定量检测方法, 2013-07-10,中国, ZL201110089936.2 

近5年发表代表性论文：

[1] Wu F-N, Zhu J, Weng G-J, Li J-J, Chen X-W, Zhao J-W. Electron transfer-based norepinephrine detection with high sensitivity regulated by polyethyleneimine molecular weight [J]. Sensors and Actuators B: Chemical, 2023, 379: 133297.

[2] Wu G-f, Zhu J, Weng G-j, Cai H-y, Li J-j, Zhao J-w. The structure and plasmonic properties regulation of Au@Ag core-shell nanostructures with Au triangular nanoprisms as the core mediated by halide [J]. Journal of Alloys and Compounds, 2023, 944: 169245.

[3] Liu Y-l, Zhu J, Weng G-j, Li J-j, Zhao J-w. Simultaneous determination of three food contaminants in shrimp paste by hollow porous pentagonal Au/Ag alloy nanotubes with excellent SERS activity [J]. Sensors and Actuators B: Chemical, 2022, 373: 132766.

[4] Wu F-N, Zhu J, Weng G-J, Li J-J, Zhao J-W. Gold nanocluster composites: preparation strategies, optical and catalytic properties, and applications [J]. Journal of Materials Chemistry C, 2022, 10(40): 14812-14833.

[5] He Z, Zhu J, Li X, Weng G-J, Li J-J, Zhao J-W. Surface etching-dependent geometry tailoring and multi-spectral information of Au@AuAg yolk-shell nanostructure with asymmetrical pyramidal core: The application in Co2+ determination [J]. Journal of Colloid and Interface Science, 2022, 625: 340-353.

[6] Li J-y, Zhu J, Weng G-j, Li J-j, Zhao J-w. Multiplex Sensing Based on Plasmonic Optics of Noble Metallic Nanostructures [J]. Critical Reviews in Analytical Chemistry, 2022: 1-13.

[7] Weng G, Shen X, Li J, Wang J, Zhu J, Zhao J. A plasmonic ELISA for multi-colorimetric sensing of C-reactive protein by using shell dependent etching of Ag coated Au nanobipyramids [J]. Analytica Chimica Acta, 2022, 1221: 340129.

[8] Liu Y, Zhu J, Weng G, Li J, Zhao J. Selective controlling transverse plasmon spectrum of pentagonal gold nanotube：from visible to near-infrared region [J]. Nanotechnology, 2021, 32(44): 445202.

[9] Wu G F, Zhu J, Weng G J, Li J J, Zhao J W. Heterodimers of metal nanoparticles: synthesis, properties, and biological applications [J]. Microchimica Acta, 2021, 188(10): 21.

[10] Yang Y, Zhu J, Weng G-j, Li J-j, Zhao J-w. Gold nanoring core-shell satellites with abundant built-in hotspots and great analyte penetration: An immunoassay platform for the SERS/fluorescence-based detection of carcinoembryonic antigen [J]. Chemical Engineering Journal, 2021, 409: 128173.

[11] Zhu J, Meng L-n, Weng G-j, Li J-j, Zhao J-w. Tuning quadruple surface plasmon resonance in gold nanoellipsoid with platinum coating: from ultraviolet to near infrared [J]. Applied Physics A, 2021, 127(8): 591.

[12] Wu F-N, Zhu J, Weng G-J, Li J-J, Zhao J-W. Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine [J]. ACS Applied Nano Materials, 2021, 4(12): 13501-13509.

[13] Yang Y, Zhao J, Weng G-j, Li J-j, Zhu J, Zhao J-w. Fine-tunable fluorescence quenching properties of core-satellite assemblies of gold nanorod-nanosphere: Application in sensitive detection of Hg2+ [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 228: 117776.

[14] Weng G, Feng Y, Zhao J, Li J, Zhu J, Zhao J. Sensitive detection of choline in infant formulas by SERS marker transformation occurring on a filter-based flexible substrate [J]. Sensors and Actuators B: Chemical, 2020, 308: 127754.

[15] He Z, Zhu J, Weng G-J, Li J-J, Zhao J-W. Detection of ferrous ion by etching-based multi-colorimetric sensing of gold nanobipyramids [J]. Nanotechnology, 2020, 31(33): 335505.

[16] Liu Y-l, Zhu J, Weng G-j, Li J-j, Zhao J-w. Gold nanotubes: synthesis, properties and biomedical applications [J]. Microchimica Acta, 2020, 187(11): 612.

[17] Li Y-l, Zhu J, Weng G-j, Li J-j, Xing T-y, Zhao J-w. “Magic mitt”: Morphologically controllable AuAg@AuAg yolk-shell nanostars with better plasmonic optical properties [J]. Journal of Alloys and Compounds, 2020, 844: 156134.

[18] Chen J-K, Zhao S-M, Zhu J, Li J-J, Zhao J-W. Colorimetric determination and recycling of Hg2+ based on etching-induced morphology transformation from hollow AuAg nanocages to nanoboxes [J]. Journal of Alloys and Compounds, 2020, 828: 154392.

[19] Weng G, Zhao X, Zhao J, Li J, Zhu J, Zhao J. Nanoplasmonic sensing of NADH by inhibiting the oxidative etching of gold nanorods [J]. Sensors and Actuators B: Chemical, 2019, 299: 126982.

[20] Zhu J, Du H-f, Zhang Q, Zhao J, Weng G-j, Li J-j, Zhao J-w. SERS detection of glucose using graphene-oxide-wrapped gold nanobones with silver coating [J]. Journal of Materials Chemistry C, 2019, 7(11): 3322-3334.

[21] Zhao J, Wu C, Zhai L, Shi X, Li X, Weng G-j, Zhu J, Li J, Zhao J-w. A SERS-based immunoassay for the detection of α-fetoprotein using AuNS@Ag@SiO₂ core-shell nanostars [J]. Journal of Materials Chemistry C, 2019, 7(27): 8432-8441

[22] Qi Y, Xing T-y, Zhao J, Weng G-j, Li J-j, Zhu J, Zhao J-w. Tuning the surface enhanced Raman scattering performance of anisotropic Au core−Ag shell hetero-nanostructure: The effect of core geometry [J]. Journal of Alloys and Compounds, 2019, 776: 934-947.

[23] Weng G, Feng Y, Zhao J, Li J, Zhu J, Zhao J. Size dependent SERS activity of Ag triangular nanoplates on different substrates: Glass vs paper [J]. Applied Surface Science, 2019, 478: 275-283.

[24] Yang Y, Zhu J, Zhao J, Weng G-J, Li J-j, Zhao J-W. Growth of spherical gold satellites on the surface of Au@Ag@SiO₂ core-shell nanostructures used for an ultrasensitive SERS immunoassay of alpha-fetoprotein [J]. ACS Applied Materials & Interfaces, 2019, 11(3): 3617–3626.

[25] Zhu J, Zhao B-z, Qi Y, Li J-J, Li X, Zhao J-W. Colorimetric determination of Hg(II) by combining the etching and aggregation effect of cysteine-modified Au-Ag core-shell nanorods [J]. Sensors and Actuators B: Chemical, 2018, 255(Part 3): 2927-2935.

[26] Zhang F, Wu N, Zhu J, Zhao J, Weng G-j, Li J-j, Zhao J-w. Au@AuAg yolk-shell triangular nanoplates with controlled interior gap for the improved surface-enhanced Raman scattering of rhodamine 6G [J]. Sensors and Actuators B: Chemical, 2018, 271: 174-182.

[27] Qi Y, Zhao J, Weng G, Li J, Zhu J, Zhao J. Modification-free colorimetric and visual detection of Hg²⁺ based on the etching from core-shell structural Au-Ag nanorods to nanorices [J]. Sensors and Actuators B: Chemical, 2018, 267: 181-190.

[28] Xing T-Y, Zhao J, Weng G-J, Li J-J, Zhu J, Zhao J-W. Synthesis of dual-functional Ag/Au nanoparticles based on the decreased cavitating rate under alkaline conditions and the colorimetric detection of mercury(ii) and lead(ii) [J]. Journal of Materials Chemistry C, 2018, 6(28): 7557-7567.

[29] Qi Y, Zhao J, Weng G-j, Li J-j, Li X, Zhu J, Zhao J-w. A colorimetric/SERS dual-mode sensing method for the detection of mercury(ii) based on rhodanine-stabilized gold nanobipyramids [J]. Journal of Materials Chemistry C, 2018, 6(45): 12283-12293.

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