凌盛龙， 中国科学技术大学生物医学工程学院特任研究员，博士生导师。2016年博士毕业于中国科学技术大学微尺度物质科学研究中心，后入职中国科学技术大学生命科学与医学部，历任博士后、特任副研究员；2024年09月加入中国科学技术大学苏州高等研究院。主要从事重大疾病相关膜蛋白的信号传导分子机制研究及靶向肿瘤、代谢及神经疾病的创新药物研发。迄今已在Cell Research、National Science Reviews、Cell Discovery 、Protein Cell、PCCP等国际学术期刊上发表SCI论文20余篇。获国家重点研发计划、国家自然科学基金等多个科研项目支持。

电子邮箱：lsl924@ustc.edu.cn

联系地址中国科学技术大学苏州高等研究院明德楼C309、C209

主要研究方向：

1.     重大疾病相关靶标膜蛋白的配体识别、变构调控机制、药效机理以及信号传导机制研究；

2.     药物靶标膜蛋白的潜在药物分子高通量筛选和精准化学改造；基于结构信息/AI辅助的药物分子理性设计

承担科研项目情况：

1.     国家自然科学基金青年项目，基于钙敏感受体的不同激活状态进行多肽变构调节剂筛选以及结构导向的化学修饰改造，2024.01-2026.12，主持

2.     科技部国家重点研发计划，蛋白质内电子传递机制在肿瘤研究中的应用，2021.12-2026.11，项目骨干

3.     中国科学技术大学青年创新基金，人源钙离子敏感受体CaSR 的激活机制研究，2023.01-2024.12，主持

重要科研获奖经历：

中科大墨子杰出青年（2021）

中国科学院朱李月华优秀博士（2016）

学术论文及著作：

1.  Ling, S.^# *, Meng, X. ^#, Zhang, Y., Xia, Z., Zhou, Y., Yang, F., Shi, P. *, Shi, C. *, and Tian, C*. (2024). Structural insights into asymmetric activation of the calcium-sensing receptor-G(q) complex. Cell research

2.  Fang, W. ^#, Yang, F. ^#, Xu, C.J. ^#, Ling, S.L. ^#, Lin, L., Zhou, Y.X., Sun, W.J., Wang, X.M., Liu, P., Rondard, P., et al. (2022). Structural basis of the activation of metabotropic glutamate receptor 3. Cell research

3.  Ling, S.L. ^#, Shi, P. ^#, Liu, S.L. ^#, Meng, X.Y. ^#, Zhou, Y.X., Sun, W.J., Chang, S.H., Zhang, X., Zhang, L.H., Shi, C.W., et al. (2021). Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca ions and L-tryptophan. Cell research  (Front Cover) (Editor’s selections: top articles from the past 3 years)

4.  Yang, F. ^#, Ling, S.L. ^#, Zhou, Y.X. ^#, Zhang, Y.A., Lv, P., Liu, S.L., Fang, W., Sun, W.J., Hu, L.A., Zhang, L.H., et al. (2021). Different conformational responses of the β-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline. Natl Sci Rev  

5.  Zhang, Y.A. ^#, Yang, F. ^#, Ling, S.L. ^#, Lv, P., Zhou, Y.X., Fang, W., Sun, W.J., Zhang, L.H., Shi, P., and Tian, C.L. (2020). Single-particle cryo-EM structural studies of the β2AR-Gs complex bound with a full agonist formoterol. Cell discovery

6.  Ling, S.L. ^#, Zhang, C.W. ^#, Wang, W., Cai, X.Y., Yu, L., Wu, F.M., Zhang, L.H., and Tian, C.L. (2016). Combined approaches of EPR and NMR illustrate only one transmembrane helix in the human IFITM3. Scientific reports

7.  Ling, S.L^#., Wang, W. ^#, Yu, L., Peng, J.H., Cai, X.Y., Xiong, Y., Hayati, Z., Zhang, L.H., Zhang, Z.Y., Song, L.K., and Tian, C.L. (2016). Structure of an integral membrane sulfurtransferase and its structural transition upon SCN binding defined by EPR-based hybrid method. Scientific reports

8.  Sun, D., Li, X., Yuan, Q., Wang, Y., Shi, P., Zhang, H., Wang, T., Sun, W., Ling, S., Liu, Y., et al. (2025). Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. Cell research

9.  Li, Y.G., Meng, X.Y., Yang, X., Ling, S.L., Shi, P., Tian, C.L., and Yang, F. (2024). Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta pharmacologica Sinica

10. Sun, W.J., Yang, F., Zhang, H.H., Yuan, Q.N., Ling, S.L., Wang, Y.X., Lv, P., Li, Z.L., Luo, Y.F., Liu, D.S., et al. (2023). Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell discovery

11.  Yang, F., Zhang, H.H., Meng, X.Y., Li, Y.G., Zhou, Y.X., Ling, S.L., Sun, D.M., Lv, P., Liu, L., Shi, P., and Tian, C.L. (2022). Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell research

12.  Bo, Q., Yang, F., Li, Y.G., Meng, X.Y., Zhang, H.H., Zhou, Y.X., Ling, S.L., Sun, D.M., Lv, P., Liu, L., et al. (2022). Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell discovery

13.  Sun, W.J., Yuan, Q.N., Zhang, H.H., Yang, F., Ling, S.L., Luo, Y.F., Lv, P., Xu, H.E., Tian, C.L., Yin, W.C., and Shi, P. (2022). Structural insights into the activation of neurokinin 2 receptor by neurokinin A. Cell discovery

14.  Shi, P., Zhang, Y.N., Lv, P., Fang, W., Ling, S.L., Guo, X.Q., Li, D., Liu, S.L., Sun, D.M., Zhang, L.H., et al. (2020). A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET. Chemical Communications

15.  Hang, T.R., Zhang, X.Z., Wu, M.H., Wang, C.L., Ling, S.L., Xu, L., Gong, Q.G., Tian, C.L., Zhang, X., and Zang, J.Y. (2018). Structural insights into a novel functional dimer of RNase HII. Biochemical and biophysical research communications

16.  Wu, K.Q., Li, W.F., Yu, L., Tong, W., Feng, Y., Ling, S.L., Zhang, L.H., Zheng, X., Yang, M.J., and Tian, C.L. (2017). Temperature-dependent ESR and computational studies on antiferromagnetic electron transfer in the yeast NADH dehydrogenase Ndi1. Phys Chem Chem Phys

17.  Zheng, Y., Wu, F.M., Ling, S.L., Li, J.B., and Tian, C.L. (2020). Total chemical synthesis of bivalently modified H3 by improved three-segment native chemical ligation. Chinese Chemical Letters

18.  Wu, Y.F., Wang, C.L., Ling, S.L., Wu, M.H., Han, L., Tian, C.L., Zhang, X., and Zang, J.Y. (2015). Octameric structure of enolase in complex with phosphoenolpyruvate. Acta Crystallogr D

19.  Yu, L., Wang, W., Ling, S.L., He, Y., Xiao, L., Wu, K.Q., Zhang, L.H., and Tian, C.L. (2014). Distance measurement between two flexible sites in proteins in high viscosity medium at physiological temperature using continuous wave EPR. Protein & cell