薛晓畅：博士，陕西师范大学生命科学学院教授，硕士研究生导师
个人简介：
1975年3月出生。1998年于陕西师范大学生命科学学院获学士学位，2005年于第四军医大学获生物化学与分子生物学专业博士学位。2008年晋升副教授，2011年遴选为硕士生导师，2019年在陕西师范大学生命科学学院任教授。2009-2011年在美国阿拉巴马大学（UAB）和德州大学医学分部（UTMB）做博士后研究。国家自然科学基金函审专家，陕西省生物化学与分子生物学学会理事。主要研究方向: ① 肿瘤及自身免疫性疾病的分子机制研究；② 基因工程蛋白质和多肽药物的开发研究。主持国家“十二五”863重大项目《肿瘤及自身免疫性疾病等治疗性疫苗关键技术及产品研发》子课题1项（2012AA02A407），国家自然科学基金项目2项(31000406, 81373201)，陕西省重点研发计划1项（2017SF-178）；承担新药创制科技重大专项3项（2009ZX09103-672、2011ZXJ09104、2013ZX09J13102-01C均为副组长），参与国家新药创制科技重大专项课题2项（2008ZXJ09004-025、08BMZX01-4），参与完成国家自然科学基金课题、军队面上项目、陕西省重点研发计划、自然科学基金、攻关计划等多项。已发表SCI论文60余篇，他引1000余次；副主编、参编专著6部；已授权国家发明专利10项。
受教育经历：
2010/02-2011/02，美国德州大学医学分院，免疫学/病理学/医学系，博士后
2009/01-2010/01，美国阿拉巴马大学，免疫学/医学系，博士后
2001/07-2005/06，第四军医大学，生物化学与分子生物学，博士
1998/07-2001/06，第四军医大学，生物化学与分子生物学，硕士
1994/09-1998/07，陕西师范大学，生命科学学院，学士
研究工作经历
2019.11-今，陕西师范大学生命科学学院教授。
2009/01-2011/02，美国，博士后。microRNA在自身免疫性疾病中的作用机制研究。
2008/09-今，第四军医大学，药学系生物制药学教研室，副教授。研究方向：①microRNA在肿瘤及自身免疫性疾病中的作用分子机制研究；②基因工程蛋白质和多肽药物的开发研究。
2005/06-2008/09，第四军医大学，药学系生物制药学教研室，讲师。研究方向：自身免疫性疾病治疗性疫苗研制
2001/06-2005/06，第四军医大学，生物技术中心，助教。研究方向：基因工程药物研制
1998/07-2001/06，第四军医大学，生物技术中心，硕士。研究方向：基因工程药物研制
基金申请：
1、 国家自然科学基金青年项目：细胞核内Galectin-1与Foxp3相互作用的验证及生物学活性的初步探讨（31000406），第一，20万元（2011.01-2013.12）
2、 国家自然科学基金面上项目：NF-κB 和miR-103 调节环路在类风湿性关节炎中的作用及机制研究（81373201），第一，70万元（2014.01-2017.12）
3、 863子课题：肿瘤及自身免疫性疾病等治疗性疫苗关键技术及产品研发（2012AA02A407），第一，35.21万元（2012.01-2015.12）
4、 陕西省重点研发计划项目：人肿瘤坏死因子重组疫苗rTNF-PADRE的研制（2017SF-178），第一，6.00万元（2017.01-2018.12）
5、 新药创制科技重大专项《重组肿瘤血管靶向性改构人TNFα的研制》（2009ZX09103-672），副组长（第二），150万元（2009.01-2010.12）
6、 新药创制科技重大专项（2013ZX09J13102-01C），副组长，125万元（2013.01-2015.12）
7、 新药创制科技重大专项（2011ZXJ09104-01B），副组长，300万元（2011.01-2015.12）
杂志审稿人：
1、 Immunologic Research
2、 Mini-reviews in Medicinal Chemistry
3、 International Journal of Biological Sciences
4、 Vaccine
5、 Protein Expression and Purification
6、 Inflammatory Bowel Diseases
7、 Journal of Cancer
8、 Journal of Cellular Biochemistry
主编、参编专著：
[1] The Research and Biology of Cancer I, Chapter 8: Novel rmhTNF-α: a Higher Anti-tumor Activity and a Lower Toxicity. iConcept Press Ltd. 2013
[2] 樊代明主编 医学发展考 第四军医大学出版社 西安 2013.11. 156万字.
[3] 王玉琨主编 军事药学 第九章 心肺脑复苏药物 第四军医大学出版社 西安 2013.
[4] 医学精品讲座(第一辑). 樊代明. 西安：第四军医大学出版社，2008.9
[5] 颜真，张英起主编 薛晓畅副主编 蛋白质研究技术 第四军医大学出版社 西安 2007.1. 36万字.
[6] 樊代明主编 肿瘤研究前沿（第5卷）西安交通大学出版社 西安 2005.12.
第一/通讯作者论文：
1、 Nan Mu#, Jintao Gu#, Tonglie Huang#, Nannan Liu, Hui Chen, Xin Bu, Zhaohui Zheng, Bo Jia, Jun Liu, Baolong Wang, Yingmei Wang, Zhenfeng Zhu, Yong Zhang, Yingqi Zhang, Xiaochang Xue*, Meng Li*, and Wei Zhang*. Blocking discoidin domain receptor 2 (DDR2) reduces inflammation and joint destruction in rheumatoid arthritis by altering IL-15 and DKK1 signalling in fibroblast-like synoviocytes. Arthritis Rheumatol. 2020 Jun; 72(6): 943-956. (IF= 9.002)
2、 Jintao Gu#, Jun Liu#, Tonglie Huang#, Wangqian Zhang, Bo Jia, Nan Mu, Kuo Zhang, Qiang Hao, Weina Li, Wei Liu, Wei Zhang, Yingqi Zhang, Xiaochang Xue*, Cun Zhang*, Meng Li*. The protective and anti-inflammatory effects of a modified glucagon-like peptide-2 dimer in inflammatory bowel disease. Biochemical Pharmacology. 2018 Sep;155:425-433. (IF= 4.825)
3、 Chu Chu#, Wangqian Zhang#, Jialin Li, Yi Wan, Zenglu Wang, Ruyi Duan, Pei Yu, Ning Zhao, Kuo Zhang, Shuning Wang, Qiang Hao, Weina Li, Cun Zhang, Wei Zhang, Yingqi Zhang, Meng Li*, Xiaochang Xue*. A single codon optimization enhances recombinant human TNF-α vaccine expression in Escherichia coli. Biomed Res Int. 2018. Apr 15;2018: 3025169. (IF=2.197)
4、 Jintao Gu#, Shuo Liu#, Nan Mu#, Tonglie Huang#, Wangqian Zhang, Huadong Zhao, Zhen Shu, Cun Zhang, Qiang Hao, Weina Li, Xiaochang Xue*, Wei Zhang*, Yingqi Zhang*. A DPP-IV-resistant glucagon-like peptide-2 dimer with enhanced activity against radiation- induced intestinal injury. J Control Release. 2017; 15;260:32-45. (IF=7.877)
5、 Kun Zhang, Yuejuan Zhang, Jing Zi, Xiaochang Xue*, Yi Wan*. Production of human Cu,Zn SOD with higher activity and lower toxicity in E. coli via mutation of free cysteine residues. Biomed Res Int. 2017; 2017: 4817376. (IF=2.46)
6、 Huang TL#, Mu N#, Gu JT#, Shu Z, Zhang K, Zhao JK, Zhang C, Hao Q, Li WN, Zhang WQ, Liu NN, Zhang Y, Zhang W*, Xue XC*, Zhang YQ*. DDR2-CYR61-MMP1 Signaling Pathway Promotes Bone Erosion in Rheumatoid Arthritis through Regulating Migration and Invasion of Fibroblast-Like Synoviocytes. J Bone Miner Res. 2017 Feb; 32(2):407-418. (IF=6.314)
7、 Mu N#, Gu J#, Huang T#, Zhang C, Shu Z, Li M, Hao Q, Li W, Zhang W, Zhao J, Zhang Y, Huang L, Wang S, Jin X, Xue X*, Zhang W*, Zhang Y*. A novel NF-κB/YY1/ microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis. Sci Rep. 2016 Jan 29; 6: 20059. doi: 10.1038/srep20059. (IF=4.259)
8、 Shu Z#, Li J#, Mu N, Gao Y, Huang T, Zhang Y, Wang Z, Li M, Hao Q, Li W, He L, Zhang C, Zhang W, Xue X*, Zhang Y. Expression, purification and characterization of galectin-1 in Escherichia coli. Protein Expr Purif. 2014 Apr 6; 99C:58-63. (IF=1.51)
9、 Feng GD#, Xue XC#*, Gao ML, Wang XF, Shu Z, Mu N, Gao Y, Wang ZL, Hao Q, Li WN, Li M, Zhang C, Zhang W, Zhang YQ*. Therapeutic effects of PADRE-BAFF autovaccine on rat adjuvant arthritis. Biomed Res Int. 2014; 2014:854954. (IF=2.706)
10、 Yu Y#, Shi X#, Shu Z#, Xie T, Huang K, Wei L, Song H, Zhang W*, Xue X*. Stromal cell-derived factor-1 (SDF-1)/CXCR4 axis enhances cellular invasion in ovarian carcinoma cells via integrin β1 and β3 expressions. Oncol Res. 2014; 21(4): 217-25. (IF=0.92)
11、 Xue X, Cao AT, Cao X, Yao S, Carlson ED, Soong L, Liu CG, Liu X, Liu Z, Duck LW, Elson CO, Cong Y*. Downregulation of MicroRNA-107 in intestinal CD11c+ myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression. Eur J Immunol. 2014 Mar; 44(3):673-82. (IF=4.97)
12、 Wei F#, Liu Y#, Guo Y, Xiang A, Wang G, Xue X*, Lu Z*. miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer. Mol Cancer 2013 Jul 25; 12(1):81. (Co-corresponding author) (IF=5.40)
13、 Xue XC, Yan Z, Li WN, Li M, Qin X, Zhang C, Hao Q, Wang ZL, Zhao N, Zhang W, Zhang YQ*. Construction, Expression, and Characterization of Thymosin Alpha 1 Tandem Repeats in Escherichia coli. Biomed Res Int. 2013; 2013:720285. (IF=2.706)
14、 Wu K#, Xue X#*, Li M, Qin X, Zhang C, Li W, Hao Q, Wang Z, Liu Q, Zhang W, Zhang Y*. High level expression, purification and characterization of recombinant CCR5 as a vaccine candidate against HIV. Protein Expr Purif. 2013; 89(2): 124-130. (Co-first, Co- corresponding author) (IF=1.51)
15、 Xue X, Feng T, Yao S, Wolf KJ, Liu CG, Liu X, Elson CO, Cong Y*. Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40. J Immunol, 2011 Dec 1; 187 (11):5879-86. (IF=5.87)
16、 Xue X#, Feng G#, Li M, Qin X, Wu S, Zhang C, You Y, Wang W, Jiang C, Liu Y, Zhu W, Ran Y, Zhang Z, Yan Z, Han W*, Zhang Y*. Amelioration of experimental autoimmune encephalomyelitis by BLyS autovaccine. Vaccine, 2008, 26(23):2873-2881. (IF=3.616)
17、 Xue X, Wang Z, Yan Z, Shi J, Han W, Zhang Y*. Production and purification of recombinant human BLyS mutant from inclusion bodies. Protein Expr and Purif, 2005, 42:194-199. (IF=1.429)
18、 Xue XC, Wu YJ, Gao MT, Li WG, Zhao N, Wang ZL, Bao CJ, Yan Z, Zhang YQ*. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol. 2004; 10 (7): 1032- 1036. (IF=2.547)
19、 薛晓畅, 成俊宏, 郭红彬, 王东方, 张喜烨, 袁晓峰, 李志兰, 王增禄. 七叶皂苷凝胶对宫颈炎大鼠的治疗作用. 分子影像学杂志, 2019, 42(3): 364-368.
20、 薛晓畅, 李志兰, 张 存, 王多宁, 王春娟, 党林涛, 王增禄. 七叶皂苷制备及其对组织水肿大鼠的疗效. 分子影像学杂志, 2019, 42 (1): 46-51.
21、 Dong Wengang; Liu Jun; Chu Chu; Mu Nan; Gu Jintao; Zhang Wangqian; Xue Xiaochang; Zhang Yingqi; Zhang Wei; Zhang Yong; Qian Jixian. The effects of PRL-3 on the migration and invasion of colorectal cancer cells. Journal Of Modern Oncology. 2018; 12: 1815-1818.
22、 褚楚, 穆楠, 顾锦涛, 黄同列, 舒震, 赵金康, 郑朝晖, 张伟, 薛晓畅. miR-10b对滑膜成纤维细胞增殖、侵袭和迁移能力的影响及分子机制. 现代生物医学进展. 已接收. 2018.
23、 高源; 郝强; 王舒宁; 张伟; 薛晓畅. 抗人白细胞介素15中和抗体识别抗原表位的噬菌体肽库筛选与鉴定. 生物技术通讯, 2015; 26(2): 182-185.
24、 薛晓畅, 李萌, 秦鑫, 李维娜, 郝强, 包春杰, 韩苇, 张英起. 重组人B淋巴细胞刺激因子工程菌生物学特性的稳定性. 中国生物制品学杂志, 2008; 21(9): 777-779.
25、 薛晓畅, 吴勇杰, 高明堂, 李文广, 赵宁, 王增禄, 颜真, 张英起. 十五肽BPC157对小型猪皮肤切割伤的保护作用研究. 中国新药杂志, 2004; 7: 602-605.
26、 薛晓畅, 颜真, 石继红, 韩苇, 张英起. 重组胸腺素α1的克隆、表达与纯化. 第四军医大学学报, 2001; 22(3): 227-230.
27、 薛晓畅, 颜真, 石继红, 韩苇, 张英起. 胸腺素A1基因串联体的构建. 第四军医大学学报, 2001-08-30.
28、 薛晓畅, 张英起. 端粒酶抑制剂与肿瘤治疗. 医学与哲学, 2000-12-08.
其他论文(IF>3)：
29、 Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum, Qiuyang Zhang. ΗΙF1α, EGR1 and SP1 Co-Regulate the Erythropoietin Receptor Expression Under Hypoxia: An Essential Role in the Growth of Non-Small Cell Lung Cancer Cells. Cell Commun Signal.2019; 17 (1), 152. (IF=5.111)
30、 Ma X, Pang Z, Zhou J, He L, Hao Q, Li W, Zhang K, Wang S, Zhang W, Xue X, Zhang W, Zhang Y, Zhang C, Li M. Acetylation and Amination Protect Angiotensin 1-7 from Physiological Hydrolyzation and Therefore Increases Its Antitumor Effects on Lung Cancer. Mol Pharm. 2018 Jun 4; 15(6):2338-2347.(IF=4.396)
31、 Nan Mu, Jintao Gu, Nannan Liu, Xiaochang Xue, Zhen Shu, Kuo Zhang, Tonglie Huang, Chu Chu, Wangqian Zhang, Li Gong, Huadong Zhao, Bo Jia, Dakuan Gao, Lei Shang, Wei Zhang, Qingdong Guo. PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways. Theranostics. 2018 Feb 7;8(6):1527-1539. (IF=8.063)
32、 Gao Y, Li X, Shu Z, Zhang K, Xue X, Li W, Hao Q, Wang Z, Zhang W, Wang S, Zeng C, Fan D, Zhang W, Zhang Y, Zhao H, Li M, Zhang C. Nuclear galectin-1-FOXP3 interaction dampens the tumor-suppressive properties of FOXP3 in breast cancer. Cell Death Dis. 2018 Mar 16; 9(4):416. (IF=5.959)
33、 Liu S, Zhang C, Zhang K, Gao Y, Wang Z, Li X, Cheng G, Wang S, Xue X, Li W, Zhang W, Zhang Y, Xing X, Li M, Hao Q. FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells. Oncotarget. 2017 Jul 4; 8(27):44694-44704. (IF=5.168)
34、 Gao Y, Wang Z, Hao Q, Li W, Xu Y, Zhang J, Zhang W, Wang S, Liu S, Li M, Xue X, Zhang W, Zhang C, Zhang Y. Loss of ERα induces amoeboid-like migration of breast cancer cells by down-regulating vinculin. Nat Commun. 2017 Mar 7; 8:14483. doi: 10.1038/ ncomms 14483. (IF=12.124)
35、 Liu H, Chen F, Wu W, Cao AT, Xue X, Yao S, Evans-Marin HL, Li YQ, Cong Y. TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells. Sci Rep. 2016 Feb 24; 6:22040. doi: 10.1038/srep22040.（IF=4.259）
36、 Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015 Apr 30;9: 2485-99.（IF=3.026）
37、 Ma X, Song Y, Zhang K, Shang L, Gao Y, Zhang W, Xue X, Jia H, Geng J, Zhou W, Dang Y, Li E, Ti X, Fan F, Zhang Y, Li M. Recombinant Mutated Human TNF in Combination with Chemotherapy for Stage IIIB/IV Non-Small Cell Lung Cancer: A Randomized, Phase III Study. Sci Rep. 2015 Apr 21; 4: 9918. doi: 10.1038/srep09918.（IF=5.228）
38、 Zhang C, Xu Y, Hao Q, Wang S, Li H, Li J, Gao Y, Li M, Li W, Xue X, Wu S, Zhang Y, Zhang W. FOXP3 suppresses breast cancer metastasis through downregulation of CD44. Int J Cancer. 2015 Sep 15; 137(6):1279-90.（IF=5.531）
39、 He L, Xue X, Wang Z, Hou E, Liu Y, Liang M, Zhang Y, Tian Z. Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression. Biochimie. 2015 Feb; 109: 27-35.（IF=3.123）
40、 Wu W, He C, Liu C, Cao AT, Xue X, Evans-Marin HL, Sun M, Fang L, Yao S, Pinchuk IV, Powell DW, Liu Z, Cong Y. miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD. Gut. 2015 Nov; 64(11):1755-64.（IF=14.921）
41、 Zhao W, Zhang C, Shi M, Zhang J, Li M, Xue X, Zhang Z, Shu Z, Zhu J, Mu N, Li W, Hao Q, Wang Z, Gong L, Zhang W, Zhang Y. The DDR2-Annexin A2-MMP13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. Arthritis Rheumatol. 2014 Sep; 66(9):2355-67.（IF=7.87）
42、 Hao Q, Zhang C, Gao Y, Wang S, Li J, Li M, Xue X, Li W, Zhang W, Zhang Y. FOXP3 inhibits NF-κB activity and hence COX2 expression in gastric cancer cells. Cell Signal. 2014 Mar; 26(3):564-9. (IF=4.47)
43、 Li W, Wang L, Jiang C, Li H, Zhang K, Xu Y, Hao Q, Li M, Xue X, Qin X, Zhang C, Wang H, Zhang W, Zhang Y. UXT is a novel regulatory factor of regulatory T cells associated with Foxp3. Eur J Immunol. 2014 Feb; 44(2):533-44. (IF=4.97)
44、 Suxia Yao, Xiaochang Xue, Anthony Cao, Heather Evans, Charles Elson, Yingzi Cong1. Microbiota down-regulates intestinal DC expression of miR-107 which targets IL-23p19 and IL-10RB (P3158) J Immunol, 2013 May 190: Meeting abstract. (IF=5.36)
45、 Xu TJ, Wang Q, Ma XW, Zhang Z, Zhang W, Xue XC, Zhang C, Hao Q, Li WN, Zhang YQ, Li M. A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing. Drug Des Devel Ther. 2013 Oct 1; 7:1075-88. (IF=3.03)
46、 Li M, Xu T, Zhang Z, Xue X, Zhang C, Qin X, Li W, Hao Q, Zhang W, Zhang Y. A Phase II Multicenter, Randomized, Double-Blind study of a recombinant mutated human tumor necrosis factor-alpha in combination with Chemotherapies in Cancer patients. Cancer Sci. 2012 Feb; 103(2):288-295. (IF=3.479)
47、 Li W, Song L, Wu S, Xue X, Zhang L, He L, Han W, Wang Q, Ling R, Zhang W, Yan Z, Zhang Y. Expression, purification and characterization of a novel soluble human thymosin alpha1 concatemer exhibited a stronger stimulation on mice lymphocytes proliferation and higher anti-tumor activity. Int J Biol Sci. 2011; 7(5):618-628. (IF=3.168)
48、 Zhang C, Wu S, Xue X, Li M, Qin X, Li W, Han W, Zhang Y. Anti-tumor immunotherapy by blockade of the PD-1/PD-L1 pathway with recombinant human PD-1-IgV. Cytotherapy. 2008; 10(7):711-719.(IF=3.471)
49、 Meng J, Yan Z, Wu J, Li L, Xue X, Li M, Li W, Hao Q, Wan Y, Qin X, Zhang C, You Y, Han W, Zhang Y. High-yield expression, purification and characterization of tumor-targeted IFN-alpha2a. Cytotherapy. 2007; 9(1):60-68. (IF=3.553)
