Yinghui Wei

　　 　　

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   Personal information

Yinghui Wei, bornin October 1989 in Sen Menxia, Henan province, ProfessorofSchool of Animal Science and Technology, Northwest A & F University, Doctoral supervisor. He was selected into the "High-level Talent Support Program" and the "Young Top Talent B1 Post" of Northwest A&F University.

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   Education and Academic Experience

2013.09—2019.01 PhD degree, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, China

2009.09—2013.07 Bachelordegree, College of Animal Science and Technology, Henan Instituteof Scienceand Technology, China

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   Work Experience

2023.03—presentProfessor, College of Animal Science and Technology, Northwest A&F University

2021.10—2023.02 Pipeline leader/Principal Investigator, HuidaGene Therapeutics Co., Ltd.

2019.08—2021.09 Postdoctoral Fellow, Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) / Institute of Neuroscience (ION), Chinese Academy of Sciences

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   Research Areas

（1）Using molecular biology and cell biology with bioinformatics to develop and optimize gene editing tools.

（2）Using gene-editing toolsandanimalcloningtechnology to generate gene-edited animal materialsforsheeporgoatbreeding, includingnewstrains (species) fordiseaseresistancebreedingandimproved productive traitbreeding.

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   Chaired Project

（1）Project title: Engineering of the mitochondrial base editor DdCBE and generation of a mouse model with Leber hereditary optic neuropathy; Project Source: National Natural Science Foundation of China Youth Program; Number: 32301251; Start and end time: 2024.01-2026.12; Amount: 0.3 million.

（2）Project title: Optimization of prime editing system and generation of sheep models using engineered pegRNA; Project Source: "Young Talent Program" of Northwest A&F University; Number: Z1013023006; Start and end time: 2023.03-2028.12; Amount: 1 million.

（3）Project title: Interspecies blastocyst complementation generates functional rat cell-derived forebrain tissues in mice; Project Source:China Postdoctoral Science Foundation; Number: 2020M681417; Start and end time: 2020.10-2021.09; Amount: 0.08 million.

6.Selected Publications (#Co-first authors, *Correspondence)

(1) Yinghui Wei#; Zhifang Li#; Kui Xu#; Hu Feng#; Long Xie#; Di Li; Zhenrui Zuo; Meiling Zhang*; Chunlong Xu*; Hui Yang*; Erwei Zuo*; Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos, Cell Discovery, 2022, 8(1): 27.

(2) Yinghui Wei#; Chunlong Xu#; Hu Feng#; Kui Xu#; Zhifang Li#; Jing Hu; Ling Zhou; Yu Wei; Zhenrui Zuo; Erwei Zuo; Wen Li*; Hui Yang*; Meiling Zhang*; Human cleaving embryos enable efficient mitochondrialbase-editing with DdCBE, Cell Discovery, 2022, 8(1): 7.

(3) Yinghui Wei#; Meiling Zhang#*; Jing Hu#; Yingsi Zhou#; Mingxing Xue#; Jianhang Yin; Yuanhua Liu; Hu Feng; Ling Zhou; Zhifang Li; Dongshuang Wang; Zhiguo Zhang; Yin Zhou; Hongbin Liu; Ning Yao; ErweiZuo; Jiazhi Hu; Yanzhi Du*; Wen Li*; Chunlong Xu*; Hui Yang*; Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor, Protein & Cell, 2023, 14: 1-17.

(4) Yinghui Wei#; Qian Gao#; Pengxia Niu#; Kui Xu; Yiqing Qiu; Yanqing Hu; Shasha Liu; Xue Zhang; Miaoying Yu; Zhiguo Liu; Bingyuan Wang; Yulian Mu*; Kui Li*; Integrative Proteomic and Phosphoproteomic Profiling of Testis from Wip1 Phosphatase-Knockout Mice: Insights into Mechanisms of Reduced Fertility, Molecular & Cellular Proteomics, 2019, 18(2): 216-230.

(5) Huawei Tong#*; Nana Liu#; Yinghui Wei#; Yingsi Zhou#; Yun Li#; Danni Wu#; Ming Jin； Shuna Cui; Hengbin Li; Guoling Li; Jingxing Zhou; Yuan Yuan; Hainan Zhang; Linyu Shi; Xuan Yao; Hui Yang*; Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase, National Science Review, 2023, nwad143.

(6) Yinghui Wei; Junhua Fan; Lin Li; Zhiguo Liu*; Kui Li; Pretreating porcine sperm with lipase enhances developmental competence of embryos produced by intracytoplasmic sperm injection, Zygote, 2016,24(4): 594-602.

(7)Yinghui Wei; Zhiguo Liu；Kui Xu; Evanna Huyhn; Paul Dyce;Jiliang Li; Weiliang Zhou; Shuren Dong; Baoliang Feng; Yulian Mu; Julang Li;Kui Li. Generation and propagation of Cluster of Differentiation 163 Biallelic Gene Editng Pigs.Scientia Agricultura Sinica, 2018 (04):770-777.

7. Contact Information

Postal Address: College of Animal Science and Technology, Northwest A&F University, Yangling, China, 712100

E-mail：yinghuiwei@nwafu.edu.cn;yinghuiwei1019@126.com