教授
药物分析与药物化学
1964年12月生。1984.07毕业于南京中医药大学，同年留校任教，从事中药质量，生物活性天然产物，中药资源开发的研究。1990年留学日本国立富山医科药科大学，历经研修生，硕士研究生，1996年取得药学博士学位。同年留该校任文部省特别研究员，主要从事生物活性天然产物的研究。1998年进入美国P&G公司日本神户亚太地区技术中心，研究开发本部工作。主要从事定量核磁共振指纹图谱及生物核磁共振对生物活性分子间相互作用的研究。2003年到南京大学化学化工学院药物化学研究所工作，聘为教授、博士生导师。
主研方向：
1.分子探针的生物转化与代谢分析；
2.生物活性天然产物（包括中药）先导化合物的分离、鉴定、合成及结构修饰；
3.抗骨质疏松及抗炎新药研发；
4.生物核磁共振技术。
在研项目：
1.教育部博士点基金：新型抗骨吸收先导化合物齐墩果酸的结构修饰及其活性相关性（2006-08年）。
2.参与了鞠晃先教授为首的2005年'生命科学中的分析新方法和新技术的研究'创新研究群体（2006-09）。
3.参与国家科技支撑计划中药资源可持续利用与产业共性技术研究，负责其中的一个子课题中药侧柏炭炮制技术研究（2007-09）。
4.参与973计划'微流控学在化学和生物医学中的应用基础研究'（2008-12）。
横向课题：医药中间体的合成研究（TEVA）。
1.Deng Zhang-Shuang, Li Jian-Xin*, Teng Peng, Li Peng and Sun Xiao-Ru, Biocatalyzed cross-coupling of sinomenine and guaiacol by Antrodiella semisupina, Organic Letters 10(6), 1119-1122, 2008.
2.Li Jian-Xin*, Liu Jun, He Cui-Cui, Yu Zhi-Yong, Yun Du, Kadota Shigetoshi, Seto Hikaru, Triterpenoids from cimicifugae rhizoma, a novel class of inhibitors on bone resorption and ovariectomy-induced bone loss, Maturitas 58(1), 59-69, 2007.
3.Li Jian-Xin*, Yu Zhi-Yong, Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes, Current Medicinal Chemistry 13(24), 2927-2951, 2006.
4.Li Jian-Xin*, Jia Hua , Cui-Cui He, Jian-Wei Zhao, Li Jian-Xin*, Investigation on inclusion interactions of aromatic molecules with methyl-β-cyclodextrin using NMR techniques, Chinese Journal of Analytical Chemistry 35, 988-992, 2007.
5.Li Jian-Xin*, Hareyama Toru, Tezuka Yasuhiro, Zhang Yuan, Miyahara Tatsuro, Kadota Shigetoshi, Five new oleanolic acid glycosides from Achyranthes bidentata with inhibitory activity of osteoclast formation, Planta Medica 71, 673-679, 2005.
6.Yuan, Li Jian-Xin*, Jianwei Zhao, Shao-zhong Wang, Yi Pan Ken Tanakad and Shigetoshi Kadota, Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation, Bioorganic & Medicinal Chemistry Letters 15, 1629-1632, 2005.
7.Chen Ting, Li Jian-Xin, Xu Qiang, Five phenylpropanoid glycosides from Smilax glabra, Phytochemistry 53, 1051-1053, 2000.
8.Chen Ting, Li Jian-Xin, Cao Jingsong, Xu Qing, Komatsu Katsuko, Namba Tsuneo, A new flavanone isolated from rhizoma smilacis glabra and the structural requirements of its derivatives for preventing immunological hepatocyte damage, Planta Medica 65, 56-59, 1999.
9.Li Jian-Xin, Qin Shi, Xiong Quan-Bo, Prasain Jeevan Kumar, Tezuka Yasuhiro, Hareyama Toru, Wang Zheng Tao, Tanaka Ken, Namba Tsuneo, Kadota Shigetoshi, Tribulusamide A and B, two new hepatoprotective lignanamides from the fruits of Tribulus terrestris, Planta Medica 64, 628-631, 19998.
10.Li Jian-Xin, Li Ping, Tezuka Yasuhiro, Namba Tsuneo, Kadota Shigetoshi, Three phenylethanoid glycosides and one iridoid glycoside from Picrorhiza scrophulariiflora, Phytochemistry 48, 537-542, 1998.
11.Li Jian-Xin, Kadota Shigetoshi, Li Huiying, T Miyahara atsurou, Wu Yi-wei, Seto Hikaru, Namba Tsuneo, Effects of cimicifugae rhizoma on serum calcium and phosphate levels in low calcium dietary rats and on bone mineral density in ovariectomized Rats, Phytomedicine 4, 379-385, 1996.
12.Kadota Shigetoshi, Li Jian-Xin, Tanaka Ken, Namba Tsuneo, Constituents of cimicifugae rhizoma ii. isolation and structures of new cycloartenol triterpenoids and related compounds from Cimicifuga foetida L, Tetrahedron 51(4), 1143-1166, 1995.
13.Li Jian-Xin, Kadota Shigetishi, Pu Xu-feng, Namba Tsuneo, Foetidinol, a new trinor-triterpenoid with a novel carbon skeleton, from a chinese crude drug 'Shengma' (Cimicifuga foetida L.) Tetrahedron Letters 35(26), 4475-4476, 1994.
电话/手机： 025-83686419
电子信箱 ： lijxnju@nju.edu.cn
工作地点：化学楼
