黄   硕

黄硕教授长期从事单分子生物物理和单分子纳米孔测序技术的新仪器，新方法研究。在纳米孔单分子成像、纳米孔检测方面具有多项原创性技术。近五年，黄硕教授于在Nature Methods、Nature Nanotechnology、JACS、Angewandte Chemie、Nature Communications、Science Advances、Nano Lett和ACS Nano等期刊发表通讯作者论文30余篇。相关著作于Nature Nanotechnology、Physics World、ASU News等期刊或媒体报道。黄硕教授所开发技术吸引到了众多投资或产业机构关注，并已展开具体的专利转化和技术落地的合作商谈。已授权国际专利2项、国内专利1项，申请PCT专利若干项。

1. Wang, K.^#; Zhang, S.^#; Zhou, X.^#; Yang, X.; Li, X.; Wang, Y.; Fan, P.; Xiao, Y.; Sun, W.; Zhang, P.; Li, W.; Huang, S.^*; Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore.Nature Methods 2023, DOI : 10.1038/s41592-023-02021-8

2. Wang, Y.^#; Zhang, S.^#; Jia, W.^#; Fan, P.; Wang, L.; Li, X.; Chen, J.; Cao, Z.; Du, X.; Liu, Y.; Wang, K.; Hu, C.; Zhang, J.; Hu, J., Zhang, P.; Chen, H.-Y.; Huang, S.^*, Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.Nature Nanotechnology 2022, 17 (9), 976-983.

3. Liu, Y.^#; Zhang, S.^#; Wang, Y.; Wang, L.; Cao, Z.; Sun, W.; Fan, P.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Nanopore identification of alditol epimers and their application in rapid analysis of alditol-containing drinks and healthcare products. Journal of the American Chemical Society 2022,144(30), 13717–13728

4. Liu, Y.; Wang, K.; Wang, Y.; Yan, S.; Du, X.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Machine Learning assisted simultaneous structural profiling of differently charged proteins in a Mycobacterium smegmatis porin A (MspA) electroosmotic trap. Journal of the American Chemical Society 2022,144(2), 757–768

5. Wang, Y.; Wang, Y.; Du, X.; Yan, S.; Zhang, P.; Chen, H.-Y.^*; Huang, S.^*, Electrode-free nanopore sensing by DiffusiOptoPhysiology, Science Advances 2019, 5(9), eaar3309.

6. Yang, J.^#; Wang, K.^#; Zhang, S.; Zheng, X.; Cui, T.; Yang, X.; Liu, Y.; Lu, D.; Wang, Y.; Tian, X.; Zhang, P.; Huang, S.^*; Xie, R.^*, Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion. Angewandte Chemie International Edition 2023 , 62(21):e202216115

7. Zhang, S.^#; Cao, Z.^#; Fan, P.^#; Wang, Y.; Jia, W.; Wang, L.; Wang, K.; Liu, Y.; Du, X.; Hu, C.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, A Nanopore-Based Saccharide Sensor. Angewandte Chemie International Edition 2022，61(33):e202203769

8. Yan, S.^#; Wang, L.^#; Wang, Y.; Cao, Z.; Zhang, S.; Du, X.; Fan, P.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Non-binary Encoded Nucleic Acid Barcodes Directly Readable by a Nanopore. Angewandte Chemie International Edition 2022, 61 (20), e202116482.

9. Liu, Y.; Pan, T.; Wang, K.; Wang, Y.; Yan, S.; Wang, L.; Zhang, S.; Du, X.; Jia, W.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Allosteric Switching of Calmodulin in a Mycobacterium smegmatis porin A (MspA) Nanopore-Trap. Angewandte Chemie International Edition 2021, 60(44), 23863–23870

10. Wang, Y.^#; Patil, K. M.^#; Yan, S.; Zhang, P.; Guo, W.; Wang, Y.; Chen, H.-Y.; Gillingham, D.^*; Huang,S.^*, Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O6-Carboxymethyl Guanine and Reveals Its Behavior in Replication, Angewandte Chemie International Edition 2019, 58(25), 8432-8436.

11.Jia, W.; Hu, C.; Wang, Y.; Gu, Y.; Qian, G.; Du, X.; Wang, L.; Liu, Y.; Cao, J.; Zhang, S.; Yan, S.; Zhang, P.; Ma, J.; Chen, H.-Y.; Huang, S.^*, Programmable Nano-Reactors for Stochastic Sensing. Nature Communications 2021.12(1), 5811

12.Wang, Y.^#; Guan, X.^#; Zhang, S.; Liu, Y.; Wang, S.; Fan, P.; Du, X.; Yan, S.; Zhang, P.; Chen, H.-Y.; Li, W.^*; Zhang, D.^*; Huang, S.^*, Structural-profiling of low molecular weight RNAs by nanopore trapping/translocation using Mycobacterium smegmatis porin A, Nature Communications 2021, 12(1), 3368.

13. Cao, J.; Jia, W.; Zhang, J.; Xu, X.; Yan, S.; Wang, Y.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore, Nature Communications 2019, 10(1), 5668.

14. Du, X.^#; Zhang, S.^#; Wang, L.; Wang, Y.; Fan, P.; Jia, W.; Zhang, P.; Huang, S.^*, Single Molecule-Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor. ACS Nano 2023, 17(3), 2881–2892

15. Wang, Y.^#; Fan, P.^#; Zhang, S.; Wang, L.; Li, X.; Jia, W.; Liu, Y.; Wang, K.; Du, X.; Zhang, P.; Huang, S.^*, Discrimination of ribonucleoside mono-, di-, and triphosphates using an engineered nanopore. ACS Nano 2022,16(12), 21356–21365

16. Jia, W.; Hu, C.; Wang, Y.; Liu, Y.; Wang, L.; Zhang, S.; Zhu, Q.; Gu, Y.; Zhang, P.; Ma, J.; Chen, H.-Y.; Huang, S.^*, Identification of Single-Molecule Catecholamine Enantiomers Using a Programmable Nanopore, ACS Nano 2022, 16(4): 6615-6624.

17. Jia, W.; Ouyang, Y.; Zhang, S.; Du, X.; Zhang, P.; Huang, S.^*, Nanopore Signatures of Nucleoside Drugs. Nano Letters 2023, 23(20), 9437–9444

18. Wang, K.^#; Yang, X.^#; Zhang, S.; Zhang, P.; Huang, S.^*, Nanopore Discrimination of Nucleotide Sugars. Nano Letters 2023, 23(18), 8620–8627

19. Yan, S.; Zhang, J.; Wang, Y.; Guo, W.; Zhang, S.; Liu, Y.; Cao, J.; Wang, Y.; Wang, L.; Ma, F.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Single Molecule Ratcheting Motion of Peptides in a Mycobacterium smegmatis Porin A (MspA) Nanopore, Nano Letters 2021, 21(15), 6703-6710.

20. Zhang, J.^#; Wang, Y.^#; Wang, Y.; Zhang, P.; Chen, H.-Y.; Huang, S.^*, Discrimination between different DNA lesions by monitoring single molecule polymerase stalling kinetics during nanopore sequencing. Nano Letters 2022，22(13), 5561–5569