华伯洋

2008-2012，南京大学匡亚明学院，学士

2012-2018，约翰霍普金斯大学生物物理系，博士

2019-2021，约翰霍普金斯大学分子生物学系，博士后

2021-2023，格飞（测序）生物技术公司，资深研究员

主要研究兴趣包括单细胞和活体单分子分析方法等，致力于：1）搭建先进的单分子显微平台；2）探索重要生物大分子的关键构象以及构效关系；3）使用单分子荧光分析技术深入研究重要生物学问题的机理，为疾病治疗和药物开发提供新机制。在Nature Methods, Nature Chemical Biology, Nature Communications, JACS, PNAS, ChemComm, Biochemistry等学术期刊发表研究论文10余篇，被引用>1000次。

1. Hua B.*, Jones C. P.*, Mitra J., Murray P. J., Rosenthal R., Ferré-D’Amaré A. R., Ha T. Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape. Nat. Commun., 2020, 11, 4531.

2. Hellenkamp B.*, Schmid S.*, et al (including Hua B.). Precision and accuracy of single-molecule FRET measurements–a multi-laboratory benchmark study. Nat. Methods, 2018, 15, 669–676.

3. Hua B.*, Panja S.*, Wang Y., Woodson S. A., Ha T. Mimicking Co-Transcriptional RNA Folding Using a Superhelicase. J. Am. Chem. Soc., 2018, 140, 10067–10070.

4. Hua B., Wang Y., Park S., Han K. Y., Singh D., Kim J. H., Cheng W., Ha T. The Single-Molecule Centroid Localization Algorithm Improves the Accuracy of Fluorescence Binding Assays. Biochemistry, 2018, 57, 1572–1576.

5. Panja S., Hua B., Zegarra D., Ha T., Woodson S. A. Metals induce transient folding and activation of the twister ribozyme. Nat. Chem. Biol., 2017, 13, 1109–1114.

6. Hua B., Han K. Y., Zhou R., Kim H., Shi X., Abeysirigunawardena S. C., Jain A., Singh D., Aggarwal V., Woodson S. A., Ha T. An improved surface passivation method for single-molecule studies. Nat. Methods, 2014, 11, 1233–1236.

7. Hua B.-Y., Wang J., Wang K., Li X., Zhu X.-J., Xia X.-H. Greatly improved catalytic activity and direct electron transfer rate of cytochrome C due to the confinement effect in a layered self-assembly structure. Chem. Commun., 2012, 48, 2316–2318.

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