毛大庆


毛大庆

教授

一、教育经历:

2006/09-2011/06 清华大学 生物学博士;

2001/09-2003/09 比利时鲁汶大学 生物信息学硕士;

1996/09-1999/07 哈尔滨工业大学 环境工程硕士;

1988/09-1992/07 辽宁大学 微生物学学士

二、工作经历:

2017/08-至今 南开大学医学院 教授;

2012/05-2017/08 天津大学 副教授;

2003/10-2012/05 沈阳药科大学 讲师-副教授;

三、研究方向和承担项目

研究方向:病原菌耐药机制、病原微生物风险防控

主持的科研项目:

1. 国自然面上项目,抗生素促进病原菌传播的机制研究”, 2024.01-2027.12,主持;

2. 中华人民共和国科学技术部, 国家重点研发计划项目/课题, 2020YFC180690, “场地抗生素及抗性基因健康暴露风险研究”, 2020.11-2024.10,主持;

3. 国自然面上项目,“人体肠道菌群中耐药基因分布和增殖机制研究”, 2019.01-2022.12,主持;

4. 国自然面上项目,“离子液体促进耐药基因增殖扩散机制研究”,2017.01-2020.12,主持;

5. 国自然面上项目,“NDM-1耐药基因在微生物菌群的多态性分布及传播扩散机制”,2015.1-2018.12,主持;

6. 国自然面上项目,“土壤抗生素抗性基因的污染特征和传播扩散机制研究”, 2013.1-2016.12,主持;

7. 国自然面上项目,“污水处理系统中以质粒和整合子携带耐药基因的分子传播机制”,2012.1-2015.12,主持;

8. 国自然面上项目,“环境中持久存在抗生素抗性基因传播机制及生态风险”,2009.1-2011.12,主持。

四、近五年代表性论文

1. WJ Hu, YC Liu, X Li, LS Lei, H Lin, QB Yuan, DQ Mao, Y Luo. Nanobody-based strategy for rapid and accurate pathogen detection: A case of COVID-19 testing. Biosensors and Bioelectronics 2024 263: 116598.

2. WJ Hu, SX Yang, XL Wang, X Li, LS Lei, H Lin, DQ Mao, Y Luo. Development of a Dual-Epitope Nanobody-Based Immunosensor with MXenes@CNTs@AuNPs for Ultrasensitive Detection of Rotavirus. Analytical Chemistry 2024 96(49): 19678-19686.

3. XL Wang, HH Zhang, SB Yu, DH Li, MR Gillings, HQ Ren, DQ Mao, JH Guo, Y Luo. Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens. The ISME Journal 2024 Vol. 18 Issue 1.

4. XX Liu, H Fang, LZ Pan, P Zhang, H Lin, HH Gao, CL Ye, DQ Mao & Y Luo. S-amlodipine induces liver inflammation and dysfunction through the alteration of intestinal microbiome in a rat model. Gut Microbes 2024 16(1): 2316923

5. YT Gao, P Zhang, YM Wei, CL Ye, DQ Mao, DS Xia, Y Luo. Porphyromonas gingivalis exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice. Journal of Clinical Periodontology 2023 50 Issue 9: 1253-1263.

6. J Hou, X Long, XL Wang, LY Li, DQ Mao, Y Luol. Global trend of antimicrobial resistance in common bacterial pathogens in response to antibiotic consumption. J Hazard Mater 2023 Vol. 442: 130042.

7. XL Wang, HH Zhang, X Long, XM Xu, H Ren, D Mao, Y Luo. Global Increase of Antibiotic Resistance Genes in Conjugative Plasmids. Microbiology Spectrum 2023 11 Issue 2.

8. P Zhang, D Mao*, HH Gao, LY Zheng, ZY Chen, YT Gao, YT Duan, JH Guo, Y Luo and HQ Ren. Colonization of gut microbiota by plasmid-carrying bacteria is facilitated by evolutionary adaptation to antibiotic treatment. The ISME Journal 2022 16: 1284–1293.

9. P Zhang, LY Zheng, YT Duan, YT Gao, HH Gao, DQ Mao and Y Luo. Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis. J Hazard Mater 2022 421: 126707.

10. J Hou, DQ Mao#, YL Zhang, RY Huang, LY Li, XL Wang and Y Luo. Long-term spatiotemporal variation of antimicrobial resistance genes within the Serratia marcescens population and transmission of S. marcescens revealed by public whole-genome datasets. J Hazard Mater 2022 Vol. 423: 127220.

11. YT Duan, SQ Liu, YT Gao, P Zhang, DQ Mao and Y Luo. Macrolides mediate transcriptional activation of the msr(E)-mph(E) operon through histone-like nucleoid-structuring protein (HNS) and cAMP receptor protein (CRP). The Journal of antimicrobial chemotherapy 2022 Vol. 77: 391–399.

12. Q Wang, YJ Duan, SP Wang, LT Wang, ZL Hou, YX Cui, J Hou, R Das, DQ Mao and Y Luo. Occurrence and distribution of clinical and veterinary antibiotics in the faces of a Chinese population. J Hazard Mater 2022 383: 121129.

13. L Liu, Q Wang, XY Wu, HM Qi, R Das, H Lin, JL Shi, SY Wang, J Yang, YG Xue, DQ Mao and Y Luo. Vancomycin exposure caused opportunistic pathogens bloom in intestinal microbiome by simulator of the human intestinal microbial ecosystem (SHIME). Environmental Pollution 2020 265: 114399.

14. L Liu, Q Wang, H Lin, R Das, SY. Wang, HM Qi, J Yang, YG Xue, DQ Mao and Y Luo. Amoxicillin Increased Functional Pathway Genes and Beta-Lactam Resistance Genes by Pathogens Bloomed in Intestinal Microbiota Using a Simulator of the Human Intestinal Microbial Ecosystem. Frontiers in Microbiology 2020 11: 1213.

15. H Lin, Q Wang, M Yuan, L Liu, ZY Chen, YH Zhao, R Das, YJ Duan, XM Xu, YG Xue, Y Luo and DQ Mao. The prolonged disruption of a single-course amoxicillin on mice gut microbiota and resistome, and recovery by inulin, Bifidobacterium longum and fecal microbiota transplantation. Environmental Pollution 2020 265: 114651.

16. H Lin, Q Wang, L Liu, ZY Chen, R Das, Y Zhao, DQ Mao and Y Luo. Colonization of Mice With Amoxicillin-Associated Klebsiella variicola Drives Inflammation via Th1 Induction and Treg Inhibition. Frontiers in Microbiology 2020 11: 1256.

17. YT Duan, HH Gao, LY Zheng, SQ Liu, Y Cao, SY Zhu, ZZ Wu, HQ Ren, DQ Mao and Y Luo. Antibiotic Resistance and Virulence of Extraintestinal Pathogenic Escherichia coli (ExPEC) Vary According to Molecular Types. FRONTIERS IN MICROBIOLOGY 2020 11: 598305.

18. YJ Duan, ZY Chen, L Tan, XL Wang, Y Xue, S Wang, Q Wang, R Das, H Lin, J Hou, L Li, DQ Mao and Y Luo. Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals. Science of The Total Environment 2019 : 135674

19. Y Xu, XL Wang, L Tan, DQ Mao and Y Luo. Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China. Environmental Science and Pollution Research 2019 26: 25208–25217.

20. L Tan, F Wang, MM Liang, XL Wang, R Das, DQ Mao and Y Luo. Antibiotic resistance genes attenuated with salt accumulation in saline soil. J Hazard Mater 2019 374: 35-42.

21. J Hou, ZY Chen, J Gao, Y Xie, L Li, S Qin, Q Wang, DQ Mao and Y Luo. Simultaneous removal of antibiotics and antibiotic resistance genes from pharmaceutical wastewater using the combinations of up-flow anaerobic sludge bed, anoxic-oxic tank, and advanced oxidation technologies. Water Research 2019 159: 511-520.

22. H Zhou, XL Wang, ZH Li, Y Kuang, DQ Mao and Y Luo. Occurrence and Distribution of Urban Dust-Associated Bacterial Antibiotic Resistance in Northern China. Environmental Science & Technology Letters 2019 5(2): 50-55.

五、荣誉和奖励

1. 天津市自然科学奖特等奖  2023

2. 教育部自然科学奖一等奖  2018

六、讲授课程

1. 病原生物学

2. 医学微生物学

3. 口腔微生物学

七、联系方式

1. 通讯地址:天津南开区卫津路94号综合实验楼A603

2. E-mail:maodq@nankai.edu.cn