Xiaojie CUI
Position: Lecturer in Chemical Biology and Organic Chemistry
Email:xiaojiecui@muc.edu.cn
Office: 1418, Science Building
Education and Research Experience
2018-Present: Lecturer at College of Life and Environmental Sciences
2015.6-2017.7: Postdoctoral Researcher, UMR3244, Institut Curie (Paris) Supervisor: Dr. Alain Nicolas
2014.7-2015.5: Research Assistant, College of Chemistry and Molecular Engineering, Peking University
2009.9-2014.7: Ph. D. in Biological Chemistry, College of Chemistry and Molecular Engineering, Peking University
2005.9-2009.7: B. S. in Chemistry, College of Chemistry and Chemical Engineering, Shandong University
Teaching
Organic Chemistry, Chemical Biology, Organic Chemistry Experiment
Research Interests
DNA and RNA higher-order structures like G-quadruplexes and i-motifs play crucial roles in gene transcription and functional regulation. Our research mainly focuses on the following aspects:
1. Structural characterization of the four-stranded nucleic acids including G-quadruplexes and i-motifs.
2. Natural small molecule ligands screening and derivatives design for regulation of nucleic acids recognition.
Selected Publications
1. Yun Zhang, Junliu Huang, Kainan Yu and Xiaojie Cui*, “G-Quadruplexes Formation by the C9orf72 Nucleotide Repeat Expansion d(GGGGCC)(n) and Conformation Regulation by Fangchinoline”, Molecules, 2023, 28, 4671.
2. Yun Zhang, Xinao Ma, Jingtian Zhang, Feixian Luo, Wenshu Wang and Xiaojie Cui*, “Design of a High-Sensitivity Dimeric G-Quadruplex/Hemin DNAzyme Biosensor for Norovirus Detection”, Molecules, 2021, 26, 7352.
3. Xiaojie Cui*, Han Chen, Qiang Zhang, Ming Xu, Gu Yuan and Jiang Zhou*, “Exploration of the structure and Recognition of a G-quadruplex in the her2 Proto-oncogene Promoter and Its transcriptional Regulation”, Sci. Rep., 2019, 9, 3966.
4. Aurèle Piazza#, Xiaojie Cui#, Michael Adrian, Frédéric Samazan, Brahim Heddi, Anh Tuân Phan* and Alain Nicolas*, “Non-Canonical G-quadruplexes Cause the hCEB1 Minisatellite Instability in Saccharomyces cerevisiae”, # co-first author, eLife, 2017, 6, e26884.
5. Xiaojie Cui, Qiang Zhang, Han Chen, Jiang Zhou, and Gu Yuan*, “ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide”, J. Am. Soc. Mass Spectrom., 2014, 25, 684.
6. Xiaojie Cui, Sen Lin, Jiang Zhou and Gu Yuan*, “Investigation of non-covalent interaction of natural flexible cyclic molecules with telomeric RNA G-quadruplexes by electrospray ionization mass spectrometry”, Rapid Commun. Mass Spectrom., 2012, 26 , 1803.
7. Xiaojie Cui, Sen Lin and Gu Yuan*, “Spectroscopic probing of recognition of the G-quadruplex in c-kit promoter by small-molecule natural products”, Int. J. Biol. Macromol., 2012, 50, 996.
8. Xiaojie Cui andGu Yuan*, “Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry”, J. Mass Spectrom., 2011, 46, 849.
9. Qiang Zhang, Xiaojie Cui, Sen Lin, Jiang Zhou, and Gu Yuan*, “Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA”, Org. Lett.,2012, 14, 6126.
10. Han Chen, Haitao Long, Xiaojie Cui, Jiang Zhou, Ming Xu and Gu Yuan*, “Exploring the Formation and Recognition of an Important G-Quadruplex in a HIF1-alpha Promoter and Its Transcriptional Inhibition by a Benzo-c-phenanthridine Derivative”, J. Am. Chem. Soc., 2014, 136, 258.
11. Sen Lin, HuipingGu, Ming Xu, Xiaojie Cui, Youyi Zhang, Wei Gao and Gu Yuan, “The Formation and Stabilization of a Novel G-Quadruplex in the 5 '-Flanking Region of the Relaxin Gene”, Plos One, 2012, 7, e31201.
