Jinbo CHENG
Position: Professor in Minzu University of China (Beijing, China)
Adress: College of Life and Environmental Science, Minzu University of China, Beijing, China.
Email: cheng_jinbo@126.com
Doctor of Science (Beijing Normal University), 2019 High-Level Excellent Talents of Minzu University of China, Professor, Master Supervisor, Visiting Scholar at Sanford-Burnham Medical Institute, Vice Chairman of Youth Committee of Beijing Neuroscience Society, Standing Committee Member of Chinese Stroke Society-Transformation Branch, Deputy Editor-in-Chief of Frontiers in Pharmacology, Topic Editor of Frontiers in Aging Neuroscience.
His research mainly focuses on the pathogenic mechanism and intervention of neurological diseases (Neurodegenerative diseases, Stroke, Depression, etc.), especially the role and regulatory mechanism of microglial activation-induced neuroinflammation. Until now, Cheng Jinbo published more than 40 SCI papers as the first author or corresponding author in Science Advances (IF=14.9), Autophagy (IF= 16.0), Cell Death and Differentiation (IF=15.8) and other internationally renowned journals. He has hosted four State Natural Science Fund of China grants (2015-2017, 2019-2020, 2021-2024, 2023-2026), and one Beijing Natural Science Foundation project grant, etc.
TEACHING：
Neurobiology, Neuropathology, Molecular Pharmacology, Brain Science and Brain Health, Introduction to Biological Sciences (biomedical component)
RESEARCH INTERESTS：
1. Research on the pathogenic mechanism of neurodegenerative diseases: focusing on the pathogenesis of Alzheimer's disease and Parkinson's disease, combining gene knockout, animal behaviour, molecular biology and other technical methods, we will focus on the role and molecular mechanism of microglia-mediated neuroinflammation in the development of the diseases, to reveal the key role of neuroinflammation in the diseases, and provide key molecular targets and new strategies for the treatment of the diseases.
2. Research on the pathogenic mechanism and intervention of affective disorders: focusing on the pathogenic mechanism of affective disorders such as depression and post-traumatic stress disorder, revealing the molecular mechanism of the occurrence of affective disorders such as depression and post-traumatic stress disorder and exploring new strategies to intervene in these disorders by establishing animal models of the diseases and combining gene knockout and drug intervention.
3. Epigenetic modification research: focusing on the role and mechanism of epigenetic regulation (RNA methylation modification, post-translational modification of proteins, etc.) in neuroinflammatory regulation and neurological diseases
PAPERS AND PUBLICATIONS:
1. Bo X, Xie F, Zhang J, Gu R, Li X, Li S, Yuan Z*, Cheng J*. Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia. Theranostics. 2023 Mar 13;13(6):1809-1822. (IF: 12.4, Front cover article)
2. Jinbo Cheng*, Yuan Dong, Jun Ma, Ruiyuan Pan, Yajin Liao, Xiangxi Kong, Xiaoheng Li, Shuoshuo Li, Pingfang Chen, Liang Wang, Ye Yu, Zengqiang Yuan*. 2021. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Science Advances. 25;7(35):eabe3600. (IF: 14.9）
3. Jinbo Cheng*, Yajin Liao, Yuan Dong, Han Hu, Nannan Yang, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Jifeng Guo, Lixia Qin, Jiezhong Yu, Cungen Ma, Jianke Li, Mingtao Li, Beisha Tang*, Zengqiang Yuan*. 2020. Microglial Autophagy Defect Causes Parkinson’s Disease-like Symptom by Accelerating Inflammasome Activation in Mice. Autophagy. 2193-2205. (IF: 16.0）
4. Jinbo Cheng, Yajin Liao, Lei Xiao, Rong Wu, Siqi Zhao, Shengyi Peng, Jun Ma, Hong Chen, Baidong Hou, Xia Zhang, Chengyu Liang, Yun Xu, Zengqiang Yuan. 2017. Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia. Cell Death and Differentiation. 24.276-287.（IF: 15.8）
5. Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou*, Zengqiang Yuan*, Jinbo Cheng*. 2020. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. Journal of Neuroinflammation. 17.205. (IF: 9.5）
6. Yajin Liao#, Jinbo Cheng#, Xiangxi Kong#, Shuoshuo Li , Xiaoheng Li , Meijuan Zhang , He Zhang , Tianli Yang , Yuan Dong , Jun Li , Yun Xu , Zengqiang Yuan*. 2020. HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. Theranostics. 2020 Jul 29;10(21):9644-9662. (IF:12.4）
7. Shuoshuo Li, Yajin Liao, Yuan Dong, Xiaoheng Li, Jun Li, Yong Cheng, Jinbo Cheng* and Zengqiang Yuan*. 2021. Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice. Journal of Neuroinflammation. 18.7 (IF: 9.5）
8. Cheng J*, Wang S, Dong Y and Yuan Z*. 2020. The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System. Front. Immunol. 11:281. doi: 10.3389/fimmu.2020.00281. （IF: 8.3）
9. YanM, Bo X, Zhang X, Zhang J, Liao Y, Zhang H, Cheng Y, Guo J* and Cheng J*. 2022. Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia. Front. Pharmacol. 13:840567. （IF: 5.8）
10. Liao Y, Dong Y and Cheng J*. 2020. The Molecular Determinants of Mitochondrial Membrane Contact with ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology. Front. Cell. Neurosci. 14:194. （IF: 5.5）
11. Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan*, Jinbo Cheng* 2020. Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury. Aging and Disease. 11(3); 523-535.（IF: 6.7）
12. Yao R, Pan R, Shang C, Li X, Cheng J*, Xu J* and Li Y*. 2020. Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function. Front. Pharmacol. 11:986. （IF: 5.8）
13. Kong X, Liao Y, Zhou L, Zhang Y, Cheng J*, Yuan Z* and Wang S*. 2020. Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo. Front. Pharmacol. 11:581011. （IF: 5.8）
14. Lujun Zhou, Qiang Zhang, Peng Zhang, Zengqiang Yuan*, Jinbo Cheng* 2017. c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death and Disease. Oct 12;8(10):e3117 .（IF: 8.4）
15. Yajin Liao, Yumin Hao, Hong Chen, Qing He, Zengqiang Yuan*, Jinbo Cheng*. 2015. Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death. Protein & Cell. 6, 434-442.（IF: 14.8）
