Lin YANG
Position: Associated Professor, Ph.D. (Chinese Academy of Medical Sciences & Peking Union Medical College)
Postal address: College of Life and Environmental Sciences, Minzu University of China, 27 Zhongguancun South Avenue, Haidian district, Beijing 100081
E-mail: 15116995486@126.com;yanglin72@muc.edu.cn
Doctor of Science, Professor, Master Supervisor. From 1998, I have been working in College of Life and Environmental Sciences, Minzu University of China after I got a master degree on botany in 1998 in Central Normal University. 2003, I went to department of Chemistry and Chemistry Engineering, Niigata University, Japan to learn chemistry for a year as a visitor. I obtained a doctoral degree from Peking Union Medical College in 2011. My research focuses on the biosynthesis and synthetic biology of plant natural medicines, I have published over 30 academic papers including Nature Communications, Journal of Agricultural and Food Chemistry and so on; and hosted 2 projects of National Natural Science Foundation of China.
Teaching
For undergraduate: Plant Biology, Plant Biology Experiment, Pharmaceutical Botany, Field Practice of Botany.
For master:Phytochemistry, Frontiers of Life Sciences.
Research Interests
Cell and tissue culture of medicinal plants
Biotransformation of natural products
Natural product research
Main research contents
1. Discovery and application of key enzymes in the biosynthesis pathway of natural medicines. Discovering key enzymes in the biosynthesis pathways of natural medicines from medicinal plants, such as glycosyltransferases, oxidases, and methyltransferases with good catalytic activity, laying the foundation for elucidating the metabolic pathways of plant natural medicines.
2. Analysis and artificial construction of biosynthetic pathways of plant natural medicines. Constructing and optimizing engineering bacteria for the production of plant natural medicines, achieving large-scale production of natural medicines, and providing a new method to solve the problem of shortage of natural medicines.
Hosted main research projects
1. 2024~2027, Project of National Natural Science Foundation of China: Study on the synthetic biology of bergenin, an active compound of traditional Chinese medicine (82373995).
2. 2016~2019, Project of National Natural Science Foundation of China: Functional characterization and biocatalytic application of quinochalcone C-glycosyltransferases from Carthamus tinctorius (81573317).
Representative papers (*corresponding author)
1. Ruiqi Yan, BinghanXie, KeboXie, QiLiuSongyangSui, Shuqi Wang, DaweiChen, JimeiLiu, RidaoChen, JunguiDai*, Lin Yang*. Unravelling and reconstructing the biosynthetic pathway of bergenin. Nature Communications|, 2024, 15:3539.
2. Songyang Sui, Kebo Xie, Ruimingqian Guo, Jungui Dai*, LinYang*. Molecular characterization of a stereoselective and promiscuous flavanone 3‑hydroxylase from Carthamus tinctorius L. Journal of Agricultural and Food Chemistry, 2023, 71: 1679-1689.
3. Yujiao Zhang, Kebo Xie, Aijing Liu, Ridao Chen, Dawei Chen, Lin Yang*, Jungui Dai*. Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius. Chinese Chemical Letters, 2019, 30: 443-446.
4. Keping Feng, Ridao Chen, Kebo Xie, Dawei Chen, Jimei Liu, Wenyu Du, Lin Yang* and Jungui Dai*. Ep7GT, a glycosyltransferase with sugar donor flexibility from Epimedium pseudowushanense, catalyzes the 7-O-glycosylation of baohuoside. Organic & Biomolecular Chemistry, 2019, 17: 8106-8114.
5. Lin Yang*, Peiyi Guo, Aijing Liu, Songyang Sui, Sha Shi, Shunxing Guo, Jungui Dai*. Aquilariaenes A-H, eight new diterpenoids from Chinese eaglewood. Fitoterapia, 2019, 133: 180-185.
6. Lili Sun, Dawei Chen, Ridao Chen, Kebo Xie, Jimei Liu, Lin Yang*, Jungui Dai*. Exploring the aglycon promiscuity of a new glycosyltransferase from Pueraria lobata. Tetrahedron Letters, 2016, 57: 1518-1521.
