周立全，教授，博士/硕士生导师，科技部重点研发计划课题负责人。长期从事生殖生物学和表观遗传学相关研究工作，目前主要通过动物模型、临床样本、干细胞模型，并结合高通量组学方法研究染色质结构和基因表达调控对配子发生、早期胚胎发育和染色质重编程过程的影响。第一/通讯作者文章分别发表在Adv Sci, Nucleic Acids Res, Dev Cell, Trends Cell Biol, Development等。

团队名称：生殖与干细胞表观遗传调控研究团队

团队介绍：本团队致力于使用生殖和干细胞模型以开展哺乳动物配子发生、早期胚胎发育和染色质重编程过程的表观遗传调控机制研究。

SELECTED PUBLICATION (Publication list, http://orcid.org/0000-0002-9332-9408)

1. Tian Q, Yin Y, Tian Y, Wang Y, Wang YF, Fukunaga R, Fujii T, Liao AH, Li L, Zhang W, He X, Xiang W, Zhou LQ. Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice. Adv Sci. 2024 May;11(20):e2308018.

2. Mei NH, Guo SM, Zhou Q, Zhang YR, Liu XZ, Yin Y, He X, Yang J, Yin TL, Zhou LQ. H3K4 Methylation Promotes Expression of Mitochondrial Dynamics Regulators to Ensure Oocyte Quality in Mice. Adv Sci. 2023 Feb 23:e2204794.


3. Li Z, Zhang X, Xie S, Liu X, Fei C, Huang X, Tang Y, Zhou LQ. H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis. Nucleic Acids Res. 2022 Jul 8;50(12):6786-6800.


4. Tian Q, Zhou LQ. Lactate Activates Germline and Cleavage Embryo Genes in Mouse Embryonic Stem Cells. Cells. 2022 Feb 4;11(3):548.


5. Wang XF, Xie SM, Guo SM, Su P, Zhou LQ. Dynamic pattern of histone H3 core acetylation in human early embryos. Cell Cycle. 2020 Sep;19(17):2226-2234.


6. Zhou LQ, Canagarajah B, Zhao Y, Baibakov B, Tokuhiro K, Maric D, Dean J. BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice. Dev Cell. 2017 Mar 13;40(5):453-466.e5.


7. Zhou LQ, Baibakov B, Canagarajah B, Xiong B, Dean J. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos. Development. 2017 Feb 1;144(3):519-528.


8. Zhou LQ, Dean J. Reprogramming the genome to totipotency in mouse embryos. Trends Cell Biol. 2015 Feb;25(2):82-91.


9. Wu J, Zhou LQ, Yu W, Zhao ZG, Xie XM, Wang WT, Xiong J, Li M, Xue Z, Wang X, Zhang P, Mao BB, Hao DL, Lv X, Liu DP. PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1. Blood. 2014 Jan 9;123(2):261-70.