Shengmin Zhang
·Personal Information
Professor Shengmin ZHANG, PhD, FBSE
The University Chair Professor of Biomedical Engineering
Director, Center for Advanced Biomaterials & Tissue Engineering, HUST
Director, Institute of Regulatory Science for Medical Devices, HUST
The President-Elect, TERMIS-AP (2021-2023)
The Vice President, Chinese Society for Biomaterials (2019-2023)
Chief Scientist, The National Key R & D Program of China (2018-2021)
E-mail: smzhang@hust.edu.cn
Tel: +86 27 8779 2216 Fax: +86 27 87792035
Recent Selected Publications（2014-2020）
Haoming Liu, Yingying Du, Jean-Philippe St-Pierre, Mads S. Bergholt, Hélène Autefage, Jianglin Wang, Mingle Cai, Gaojie Yang, Molly M. Stevens*, Shengmin Zhang*. Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state. Science Advances 2020, 6, eaay7608 (A Cover Highlight)
Matthew. L. Bedell, Adam. M. Navara, Yingying Du, Shengmin Zhang*, and Antonios G. Mikos*. Polymeric systems for bioprinting. Chemical Reviews, 2020, 120, 10744−10792. （A Cover Highlight）
Xiao Li, Yifan Wang, Yan Chen, Pan Zhou, Kang Wei, Huan Wang, Jianglin Wang, Huang Fang*, Shengmin Zhang*. Hierarchically constructed selenium-doped bone-mimetic nanoparticles promote ROS-mediated autophagy and apoptosis for bone tumor inhibition, Biomaterials 2020, 257, 120253
Gaojie Yang, Haoming Liu, Yi Cui, Jiaqi Li， Xuan Zhou, Nuoxin Wang, Feige Wu, Yan Li，Yu Liu, Xingyu Jiang*, Shengmin Zhang*. Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration, Biomaterials 2021, 268, 120561
Yao Zha, Tianyi Lin, Yawu Li, Xin Zhang, Zihao Wang, Zubing Li, Yongqin Ye, Bin Wang*, Shengmin Zhang*, Jianglin Wang*. Exosome-mimetics as an engineered gene-activated matrix induces in-situ vascularized osteogenesis. Biomaterials, 2020, 247, 119985
Zihao Wang, Chungeng Liu, Di Zhu, Xiang Gu, Yin Xu, Qinghua Qin, Nianguo Dong, Shengmin Zhang*, Jianglin Wang*. Untangling the co-effects of oriented nanotopography and sustained anticoagulation in a biomimetic intima on neovessel remodeling. Biomaterials, 231,119654, 2020.
Haoming Liu, Yingying Du, Gaojie Yang, Xixi Hu, Lin Wang, Bin Liu, Jianglin Wang, and Shengmin Zhang*. Delivering proangiogenic factors from 3D-printed polycaprolactone scaffolds for vascularized bone regeneration. Advanced Healthcare Materials 2020, 2000727. （A Cover Highlight）
Weikang Hu, Zijian Wang, Yao Zha, Xiang Gu, Wenjie You, Yu Xiao, Xinghuan Wang*, Shengmin Zhang*, and Jianglin Wang*, High flexible and broad antibacterial nanodressing induces complete skin repair with angiogenic and follicle regeneration. Advanced Healthcare Materials, 2020, 2000035.
Yingying Du, Jason L. Guo, Jianglin Wang, Antonios G. Mikos*, Shengmin Zhang*. Hierarchically designed bone scaffolds: from internal cues to external stimuli. Biomaterials, 2019, 218, 119334
Shenglong Tan, Shangsi Chen, Yifan Wang a,b, Feige Wu, Yufei Shi, Jianglin Wang, Yingying Du, Shengmin Zhang∗，Enhanced effect of nano-monetite hydrosol on dentin remineralization and tubule occlusion, Dental Materials, 2020, https://doi.org/10.1016/j.dental.2020.03.028
Yan Li, Hang Hao, Zhengyu Zhong, Mengdie Li, Jiaqi Li, Yingying Du, Xiaodan Wu, Jianglin Wang, and Shengmin Zhang*. Assembly mechanism of high-crystallized selenium-doped hydroxyapatite nanorods via particle attachment and their effect on stem cells fate. ACS Biomaterials Science and Engineering, 2019, 5, 12, 6703-6714
Yingying Du, Haoming Liu, Qin Yang, Shuai Wang, Jianglin Wang, Jun Ma, Insup Noh, Antonios G. Mikos*, Shengmin Zhang*. Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits. Biomaterials, 2017, 137: 37-48
Gaojie Yang, Haoming Liu,Xixi Hu,Zetao Chen,Thor E. Friis,Jianglin Wang,Yin Xiao* and Shengmin Zhang*. Bio-inspired hybrid nanoparticles promote vascularized bone regeneration in a morphology-dependent manner. Nanoscale, 2017, 9: 5794-5805 （A Cover Highlight）
Yifan Wang, Jianglin Wang, Hang Hao, Mingle Cai, Shiyao Wang, Jun Ma, Yan Li, Chuanbin Mao,* and Shengmin Zhang*. In vitro and in vivo mechanism of bone tumor inhibition by selenium-doped bone mineral nanoparticles. ACS Nano, 2016, 10: 9927-9937
Jianglin Wang, Gaojie Yang, Yifan Wang, Yinying Du, Haoming Liu,Ye Zhu, Chuanbin Mao,* and Shengmin Zhang*. Chimeric protein template-induced shape control of bone mineral nanoparticles and its impact on mesenchymal stem cell fate. Biomacromolecules, 2015, 16: 1987-1996
Yanhua Wang, Hang Hao, Haoming Liu, Yifan Wang, Yan Li, Gaojie Yang, Jun Ma, Chuanbin Mao,* and Shengmin Zhang*. Selenite-releasing bone mineral nanoparticles retard bone tumor growth and improve healthy tissue functions in vivo. Advanced Healthcare Materials, 2015, 4: 1813-1818 （A Cover Highlight）
Jun Ma, Jianglin Wang, Xin Ai, Shengmin Zhang*. Biomimetic self-assembly of apatite hybrid materials: From a single molecular template to bi-/multi-molecular templates. Biotechnology Advances, 2014, 32:744–760
Guest-edited Special Issue：
Shengmin Zhang and Antonios G. Mikos. Biomaterials for Regenerative Medicine. Advanced Healthcare Materials, Vol 9, No 23, 2020. WILEY-VCH. Germany.
Major Grants（PI: Shengmin Zhang）
2018-2021 National Key R & D Project “Biomaterials and Controlled Release System for Accelerated Tissue Regeneration”
2019-2022 National Science Foundation of China (NSFC) “3D Printing Bio-energy Active Materials for Bone Regeneration”
2016-2021 Key Projects from Ministry of Education of China and Ministry of Finance of China: “Key Innovative Team for Interdisciplinary Advancement on Biomaterials and Regenerative Medicine”
2016-2019 NSFC Key Project: “Influence and Its Regulation of 3-D Micro-Pattern Structure of Biomaterials on MSCs Differentiation”
2016-2017 NSFC Key Project for International Cooperation: “Biomimetic gradient regenerative medical materials for repairing complex defects of cartilage and bone”
2016-2019 NSFC: “Study on Fabrication of Bioenergic Materials Based on ATP-Pathway and its Molecular Mechanism of Promoting Bone Repair”
2012-2016 National Key Project for Science and Technology Development “Innovative Biomaterials Devices for Bone and Spine Repair and Regeneration”
2012-2016 National Key Basic Science Project: “Controlled Preparation of Micro/Nano-Multi-scale Structural Biomaterials for Accelerated Bone Regeneration”
2011-2013 International Cooperative Program of Ministry of Science and Technology of China: “Surface Coating of PEEK with Functional Element Doped Hydroxyapatite and its Application”
2011-2013 NSFC: “Molecular Mechanism Discovery of Bone Healing Triggered by Ca-P Bone Substitutes Containing Elements Si and Zn”
2009-2011 NSFC: “A New Fabrication for Biominerization Nano-Bone Materials Based on Composite Template Co-assembly and Their Mechanism”
2006-2010 National “863” High-Tech Program: “Novel Controlled Degradable Biomaterials Composed of Inorganic and Organic Composition for Repairing of Bone and Cartilage defects”