Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications
发布时间：2023-02-14 点击次数：
论文类型：期刊论文
发表刊物：Advanced Functional Materials
收录刊物：SCI
学科门类：工学
文献类型：J
发表时间：2023-02-05
影响因子：19.92
摘要：The integration of bio‐adaptable performance, elaborate structure, and biological functionality for degradable bone implants is crucial in harnessing the body's regenerative potential to remold load‐bearing bone defects. Herein, material–structure–function integrated additive manufacturing (MSFI‐AM) is deployed to innovate novel zinc‐based bone implants, namely Zn–Mg–Cu alloy. In situ alloying of AM and boundary engineering strategy yield prominent mechanical properties, and the degradation products enable a mechanical self‐strengthened effect, thus coordinating mechanical degeneration and promoting mechanical adaptability. In addition, MSFI‐oriented Zn alloy implants successfully manifest in situ multifunctions of augmenting osteogenesis, immunoregulation, angiogenesis, and anti‐infective activity in vitro and expediting bone ingrowth and regeneration in vivo through the sustained release of divalent metal cations and triply periodic minimal surface (TPMS) structure construction. Overall, MSFI‐AMed Zn alloy implants signify promising clinical translation prospects for load‐bearing applications, and an integrated approach is proposed to endow degradable bone implants with boosted bio‐adaptable performance and in situ bio‐multifunctions.
发布期刊链接：https://doi.org/10.1002/adfm.202213128
