职务：讲师，硕士生导师

系所：环境医学研究所

地址：湖北省武汉市航空路13号公共卫生学院，430030

邮箱：lhx@hust.edu.cn

个人简介

       华中科技大学同济医学院公共卫生学院研究生导师，在华中科技大学公共卫生学院获博士学位，在美国纽约大学、华科公卫学院完成博士后研究。长期从事环境流行病学研究，基于疾病与健康的胎儿起源理论，探索环境污染物对儿童发育的不良健康影响，寻找儿童疾病的早期标志物，探索改善儿童健康状态的干预措施。参与我国华中地区的大型出生队列“武汉健康宝贝队列（Wuhan Healthy Baby Cohort, WHBC）”的筹建、管理工作，是WHBC的主要研究骨干之一。以第一作者、通讯作者在Science bulletin、BMC medicine、ES&T、J Hazard Mater、Environ Int等环境与健康权威杂志发表多篇SCI论文，阐述了环境污染物包括农药、塑化剂、全氟化合物在新生儿人群中的暴露状态、健康效应等。主持国家自然科学基金面上项目、青年项目、中国博士后科学基金面上资助项目，作为主要骨干参与多项国家自然科学基金重点项目、面上项目和国家重点研发计划。作为主要会务成员筹办了我国第一届“出生队列国际研讨会（The 1st International Symposium on Birth Cohort, ISBC）”。受邀成为SCI杂志ES&T、Environ Int、Environ Pollut等的审稿人，任英文期刊BMC birth and pregnancy、Hygiene and Environmental Health Advances的青年编委。参编多项环境与健康领域的全国团体标准或行业标准。

研究方向                                                                                        

1）   孕妇妊娠期疾病发病规律、儿童生长发育规律和不良状态的流行病学研究。

2）   生命早期不良环境因素对胎儿发育、儿童肥胖、性早熟以及神经发育的影响。

3）   基于多组学研究不良环境因素所致母婴健康效应中的相关机制。

4）   环境暴露健康风险的综合评价和防控对策。

主持项目：

国家自然科学基金面上项目、国家自然科学基金青年项目、中国博士后基金等。

代表性论著:

[1].    Yun Huang, Zhenxian Jia, Xinhe Lu, Yin Wang, Ruizhen L, Aifen Zhou, Lei Chen, Yuyan Wang, Huai-Cai Zeng, Pei Li, Akhgar Ghassabian, Ningxue Yuan, Fanjuan Kong, Shunqing Xu *, Hongxiu Liu *. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and ASD-Related Symptoms in Early Childhood: Mediation Role of Steroids. Environ Sci Technol. 2024 Sep 3. doi: 10.1021/acs.est.4c04500

[2].    Yin Wang, Yuyan Wang, Ruizhen Li, Baiwen Ni, Ruixin Chen, Yun Huang, Rongrong Cheng, Pei Li, Han Li, Yang Peng, Xue Chen, Jingyu Wang, Yuehao Fu, Chenhui Yang, Ningxue Yuan, Xianhe Xiao, Yizhao Huang, Huaicai Zeng, Wei Xia, Yuanyuan Li, Shunqing Xu, Lei Chen *, Hongxiu Liu *. Low-grade systemic inflammation links heavy metal exposures to mortality: A multi-metal inflammatory index approach. Sci Total Environ. 2024 Oct 15:947:174537. doi: 10.1016/j.scitotenv.

[3].    Xinmei Chen #, Hongxiu Liu #, Yuanyuan Li, Wenxin Zhang, Aifen Zhou, Wei Xia, Shunqing Xu. First-trimester fetal size, accelerated growth in utero, and child neurodevelopment in a cohort study. BMC Med. 2024 Apr 29;22(1):181. doi: 10.1186/s12916-024-03390-3

[4].    Hongxiu Liu #*, Yun Huang, Yitao Pan, Rongrong Cheng, Xiaojun Li, Yuanyuan Li, Shi Lu, Aifen Zhou, Jiayin Dai, Shunqing Xu. Associations between per and polyfluoroalkyl ether sulfonic acids and vitamin D biomarker levels in Chinese newborns. The Science of the total environment. 2023 Mar 25;866:161410.

[5].    Xiaojun Li#, Hongxiu Liu #, Hongxia Wan, Yuanyuan Li, Shunqing Xu, Han Xiao, Wei Xia. Sex-specific associations between legacy and novel per- and polyfluoroalkyl substances and telomere length in newborns in Wuhan, China: Mixture and single pollutant associations. The Science of the total environment. 2023 Jan 20;857(Pt 3):159676.

[6].    Hongxiu Liu #, YuyanWang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Yu Chen, Linda G. Kahn, Melanie H.Jacobson, Bo Gu, Shilpi Mehta-Lee, Sara G.Brubaker, Akhgar Ghassabian *, LeonardoTrasande. Determinants of phthalate exposures in pregnant women in New York City. Environmental research 2022, 212, 113203.

[7].    Hongxiu Liu #, Yitao Pan #, Shuna Jin, Xiaojie Sun, Yangqian Jiang, Yuyan Wang, Akhgar Ghassabian, Yuanyuan Li, Wei Xia, Qianqian Cui, Bin Zhang, Aifen Zhou, Jiayin Dai *, Shunqing Xu *. Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China. Journal of hazardous materials 2021, 407, 124378.

[8].    Hongxiu Liu  # *, Anna Maria Campana , Yuyan Wang , Kurunthachalam Kannan , Mengling Liu , Hongkai Zhu , Shilpi Mehta-Lee , Sara G Brubaker , Linda G Kahn , Leonardo Trasande , Akhgar Ghassabian, Organophosphate pesticide exposure: Demographic and dietary predictors in an urban pregnancy cohort. Environmental pollution 2021, 283, 116920.

[9].    Li YY, Liu HX, Xia W, Wong GWK, Xu SQ. Cold chain logistics: a possible mode of SARS-CoV-2 transmission? BMJ. 2021 Dec 1;375:e066129.

[10]. Lu, X.; Zhang, L.; Du, H.; Zhang, J.; Li, Y. Y.; Qu, J.; Zhang, W.; Wang, Y.; Bao, S.; Li, Y.; Wu, C.; Liu, HX.; Liu, D.; Shao, J.; Peng, X.; Yang, Y.; Liu, Z.; Xiang, Y.; Zhang, F.; Silva, R. M.; Pinkerton, K. E.; Shen, K.; Xiao, H.; Xu, S.; Wong, G. W. K., SARS-CoV-2 Infection in Children. The New England journal of medicine 2020, 382, (17), 1663-1665.

[11]. Hongxiu Liu # , Yitao Pan # , Shuna Jin , Yuanyuan Li , Liuqing Zhao , Xiaojie Sun , Qianqian Cui , Bin Zhang , Tongzhang Zheng , Wei Xia , Aifen Zhou , Anna Maria Campana , Jiayin Dai * , Shunqing Xu *, Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns. Environment international 2020, 140, 105636.

[12]. Hongxiu Liu # , Jiufeng Li #, Wei Xia , Bin Zhang , Yang Peng , Yuanyuan Li , Yanqiu Zhou , Jing Fang , Hongzhi Zhao , Yangqian Jiang , Wenyu Liu , Xiaojie Sun , Cheng Hu , Zongwei Cai * , Shunqing Xu *, Blood pressure changes during pregnancy in relation to urinary paraben, triclosan and benzophenone concentrations: A repeated measures study. Environment international 2019, 122, 185-192.

[13]. Hongxiu Liu # , Shi Lu # , Bin Zhang , Wei Xia , Wenyu Liu , Yang Peng , Hongling Zhang , Kangbing Wu , Shunqing Xu , Yuanyuan Li *. Maternal arsenic exposure and birth outcomes: A birth cohort study in Wuhan, China. Environmental pollution 2018, 236, 817-823.

[14]. Hongxiu Liu, Jiaqiang Liao , Yangqian Jiang , Bin Zhang , Huifang Yu , Jiawei Kang , Cheng Hu , Yuanyuan Li , Shunqing Xu *, Maternal exposure to fine particulate matter and the risk of fetal distress. Ecotoxicology and environmental safety 2019, 170, 253-258.

[15]. Yanqiu Zhou #, Hongxiu Liu # , Jiufeng Li , Shunqing Xu , Yuanyuan Li , Hongzhi Zhao , Hangbiao Jin , Wenyu Liu , Arthur C K Chung , Yanjun Hong , Xiaojie Sun , Yangqian Jiang , Wenxin Zhang , Jing Fang , Wei Xia *, Zongwei Cai *. Profiles, variability, and predictors of urinary benzotriazoles and benzothiazoles in pregnant women from Wuhan, China. Environment international 2018, 121, (Pt 2), 1279-1288.

[16]. Jing Fang #, Hongxiu Liu # , Hongzhi Zhao , Minghung Wong , Shunqing Xu *, Zongwei Cai *. Association of prenatal exposure to organochlorine pesticides and birth size. The Science of the total environment 2019, 654, 678-683.

[17]. Jing Fang #, Hongxiu Liu # , Hongzhi Zhao , Yanqiu Zhou , Shunqing Xu * , Zongwei Cai *. Association of in utero hexachlorocyclohexane exposure with gestational age. Ecotoxicology and environmental safety 2019, 174, 263-269.

[18]. Hongxiu Liu # , Wei Xia #, Shunqing Xu , Bin Zhang , Bin Lu , Zheng Huang , Hongling Zhang , Yangqian Jiang , Wenyu Liu , Yang Peng , Xiaojie Sun , Yuanyuan Li * . Cadmium body burden and pregnancy-induced hypertension. International journal of hygiene and environmental health 2018, 221, (2), 246-251.

[19]. Jing Fang #, Hongxiu Liu # , Hongzhi Zhao , Shunqing Xu *, Zongwei Cai *.. Concentrations of organochlorine pesticides in cord serum of newborns in Wuhan, China. The Science of the total environment 2018, 636, 761-766.

[20]. Jiang, Y.; Li, J.; Xu, S.; Zhou, Y.; Zhao, H.; Li, Y.; Xiong, C.; Sun, X.; Liu, HX.; Liu, W.; Peng, Y.; Hu, C.; Cai, Z.; Xia, W., Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years. Journal of hazardous materials 2020, 388, 121774.

#Co-first authors * Corresponding author