23) Zheng Y, Hu Q-Q, Huang Q, Xie Y*; "Late-Stage C−H Nitration of Unactivated Arenes by Fe(NO3)3·9H2O in Hexafluoroisopropanol"; Org. Lett.; 2024; 26; 3316-3320.
Release time:2024-04-24
Hits:
- Indexed by:
- Journal paper
- Journal:
- Organic Letters
- Included Journals:
- SCI
- Discipline:
- Science
- Volume:
- 26
- Page Number:
- 3316-3320
- ISSN No.:
- 1523-7060
- DOI number:
- 10.1021/acs.orglett.4c01006
- Date of Publication:
- 2024-04-10
- Abstract:
- Operationally simple and generally applicable arene nitration with cheap and easily accessible chemicals has been a long sought transformation in the synthetic organic community. In this work, we realized this goal with nontoxic and inexpensive Fe(NO3)3·9H2O as the nitro source and easily recyclable solvent hexafluoroisopropanol as the promotor via a network of hydrogen-bonding interactions. As a result of the relative mildness and high reliability of this protocol, late-stage nitration of various highly functionalized natural products and commercially available drugs was realized.
- Links to published journals:
- https://pubs.acs.org/doi/10.1021/acs.orglett.4c01006?ref=PDF