杨培周-食品与生物工程学院

- 姓名：杨培周
- 职务：
- 职称：副教授、硕导
- 所属系：食品科学与工程系
- 邮箱：yangpeizhou@163.com
  yangpeizhou@hfut.edu.cn
- 办公地点：食品楼817

个人简介
研究领域
科研项目
学术成果
荣誉奖项

学习经历：

2005-09至2008-06,华南农业大学,农产品加工及贮藏工程,博士

2002-09至2005-06,华南农业大学,作物遗传育种,硕士

1997-09至2001-06,华南农业大学,茶学,学士

工作经历：

2017-09至今,合肥工业大学,食品与生物工程学院,副教授

2016-09至2017-08,美国伊利诺伊大学厄巴纳-香槟分校（UIUC）,食品科学与人类营养系,副教授

2012-12至2016-08,合肥工业大学,食品与生物工程学院,副教授

2008-07至2012-11,合肥工业大学,食品与生物工程学院,讲师

2009-04至2011-04,合肥工业大学博士后

1.基因编辑技术和合成生物学
基于基因编辑的酵母工程菌改造，提高乙醇产率、耐胁迫能力，增加底物的利用率；采用代谢工程和系统生物学原理，改造微生物代谢路径提高NAD及辅酶A等高附加值辅因子的表达和积累；改造菌种代谢路径提高微生物氨基酸积累和表达。
2.食品酶工程和益生菌开发
适应于黄曲霉毒素、呕吐毒素和玉米赤霉烯酮等生物毒素降解新酶的开发和创制；采用机器学习和分子对接等方法设计和创制新型人工酶；开发适用于饲料和食品的功能性益生菌，包括酵母、乳酸菌和枯草芽孢杆菌等。

1.粮食淀粉质生物发酵及分子筛膜制备高纯电子级乙醇的关键技术研发及产业化（202003c08020001），安徽省科技重大专项—重大科技成果工程化研发项目，主持。
2.蛋白基豆制品酶法高值化加工技术集成熟化及示范推广（202103b06020014），安徽省科技重大专项，主持。
3.酥松加工关键技术及质量控制体系研究（1604a0702001），安徽省科技攻关计划项目，主持。
4.云芝黄曲霉毒素解毒酶的酵母基因工程菌构建及解毒机制研究（1908085MC80），安徽省自然科学基金面上，主持。
5.高表达多功能纤维素酶基因的黑曲霉基因工程菌构建（1408085MC67），安徽省自然科学基金面上，主持。
6.基于基因编辑技术产高纯乙醇酿酒酵母的分子改造及碳架物质流调动机制研究（2022047），合肥市自然科学基金，主持。
7.粮食真菌毒素检测及质量控制关键技术研究（PA2020GDSK0058），合肥工业大学安徽省农产品精深加工重点实验室自主创新专项，校内主持。
8.茶道与茶艺（2020mooc398），安徽省省级质量工程，主持。
9.广东省省部产学研合作专项资金 (2012B091100377)，主持。
10.体外无细胞酶级联催化产氢研究（20100470825），中国博士后基金，主持。
11.潮州市芡实蛋白肽螯合钙高效制备关键技术及产业化示范（2013B011301002），潮州市科技计划项目，主持。
12.蜂蜜功能食品的研制（W2019JSKF0034），横向，主持。
13.微生物辅助发酵的臭鳜鱼生产技术研发（W2015JSKF0076），横向，主持。
14.大豆全果仁植物蛋白饮品生产关键技术研究及产业化（W2020JSKF0691），横向，主持。
15.小麦面粉抗老化酶制剂开发及应用（W2019JSKF0681），横向，主持。

1 Peizhou Yang*; Zhuanzhuan Lin; Jianchao Chen; Shuying Jiang; Zhi Zheng; Kanglin Wang**. S. cerevisiae ERG5DeltaNTH1DeltaAMS1Delta construction enhancing stress tolerance for ethanol production increase in the presence of inhibitors and mechanism analysis based on the comparative transcriptomics, Heliyon, 2024, e37885. in press.
2 Wu, Wenjing; Lu, Shuhua; Jiang, Suwei; Chen, Jianchao; Zheng, Zhi; Jiang, Shaotong; Yang, Peizhou*. Immobilization of recombinant Trametes versicolor aflatoxin B1-degrading enzyme (TV-AFB1D) with montmorillonite for absorption and in situ degradation of aflatoxin B1. Mycotoxin Research, 2024. DOI10.1007/s12550-024-00520-x.
3 Peizhou Yang*; Jianchao Chen; Wenjing Wu; Suwei Jiang; Yanhong Deng; Jiuling Lu; Hu Wang; Yong Zhou; Yuyou Geng; Zhi Zheng. Saccharomyces cerevisiae MET5DeltaSIZ1Delta enhancing organic acid tolerance with XYL1 and XYL2 integration for ethanol yield improvement in the presence of xylose and low pH value. LWT - Food Science and Technology 180 (2023) 114718.
4 Peizhou Yang*; Wenjing Wu; Jianchao Chen; Suwei Jiang; Zhi Zheng; Yanhong Deng; Jiuling Lu; Hu Wang; Yong Zhou; Yuyou Geng; Kanglin Wang. Thermotolerance improvement of engineered Saccharomyces cerevisiae ERG5 Delta ERG4 Delta ERG3 Delta, molecular mechanism, and its application in corn ethanol production. Biotechnology for Biofuels and Bioproducts (2023) 16:66.
5 Yang, Peizhou; Wu, Wenjing; Zhang, Danfeng; Cao, Lili; Cheng, Jieshun. AFB1 Microbial Degradation by Bacillus subtilis WJ6 and Its Degradation Mechanism Exploration Based on the Comparative Transcriptomics Approach. Metabolites,2023, 13(7). DOI10.3390/metabo13070785.
6 Yang, Peizhou*; Jiang, Shuying; Lu, Shuhua; Jiang, Suwei; Jiang, Shaotong; Deng, Yanhong; Lu, Jiuling; Wang, Hu; Zhou, Yong. Ethanol yield improvement in Saccharomyces cerevisiae GPD2 Delta FPS1 Delta ADH2 Delta DLD3 Delta mutant and molecular mechanism exploration based on the metabolic flux and transcriptomics approaches, Microbial Cell Factories 2022,21(1):160.
7 Yang, Peizhou*; Jiang, Shuying; Jiang, Suwei; Lu, Shuhua; Zheng, Zhi; Chen, Jianchao; Wu, Wenjing; Jiang, Shaotong. CRISPR-Cas9 Approach Constructed Engineered Saccharomyces cerevisiae with the Deletion of GPD2, FPS1, and ADH2 to Enhance the Production of Ethanol, Journal of Fungi, 2022,8(7):703.
8 Peizhou Yang*; Wei Xiao;, Shuhua Lu; Shuying Jiang; Suwei Jiang; Jianchao Chen; Wenjing Wu; Zhi Zheng; Shaotong Jiang. Characterization of a Trametes versicolor aflatoxin B1-degrading enzyme (TV-AFB1D) and its application in the AFB1 degradation of contaminated rice in situ,Front. Microbiol.2022, 13:960882. doi: 10.3389/fmicb.2022.960882.
9 Yang, Peizhou*; Xiao, Wei; Lu, Shuhua; Jiang, Suwei; Zheng, Zhi; Zhang, Danfeng; Zhang, Min; Jiang, Shaotong; Jiang, Shuying. Recombinant Expression of Trametes versicolor Aflatoxin B1-Degrading Enzyme (TV-AFB1D) in Engineering Pichia pastoris GS115 and Application in AFB1 Degradation in AFB1-Contaminated Peanuts. Toxins (Basel), 2021. 13(5).
10 Yang, Peizhou*; Lu, Shuhua; Xiao, Wei; Zheng, Zhi; Jiang, Suwei; Jiang, Shaotong; Jiang, Shuying; Cheng, Jieshun; Zhang, Danfeng. Activity enhancement of Trametes versicolor aflatoxin B-1-degrading enzyme (TV-AFB(1)D) by molecular docking and site-directed mutagenesis. Food and Bioproducts Processing, 2021. 129: 168-175.
11 Zhang, H.; Zhai, C.; Yang, P.; Yuan, C.; Fu, N.; Zhu, M., In Situ Growth of BiOI/MoS2 Heterostructure as Pt Supports for Visible Light-Assisted Electrocatalytic Methanol Oxidation Reaction. Energy Technology 2020, 8 (1).
12 Yang, P.; Du, M.; Cao, L.; Yu, Z.; Jiang, S., Preparation and Characterization of Emulsion-based Peony Seed Oil Microcapsule. Journal of oleo science 2020, 69 (3), 219-226.
13 Jiang, S.; Xiao, W.; Zhu, X.; Yang, P.*; Zheng, Z.; Lu, S.; Jiang, S.; Zhang, G; .Liu, J., Review on D-Allulose: In vivo Metabolism, Catalytic Mechanism, Engineering Strain Construction, Bio-Production Technology. Frontiers in Bioengineering and Biotechnology 2020, 8.
14 Mu, D.; Li, H.; Li, X.; Zhu, J.; Qiao, M.; Wu, X.; Luo, S.; Yang, P.; Zhao, Y.; Liu, F.; Jiang, S.; Zheng, Z., Enhancing laccase-induced soybean protein isolates gel properties by microwave pretreatment. Journal of Food Processing and Preservation 2020.
15 Yang, P.; Jiang, S.; Wu,Y.; Hou, Z.; Zheng, Z.; Cao, L.; Du,M.; Jiang,S. Recombinant Expression of Serratia marcescens Outer Membrane Phospholipase A (A1) in Pichia pastoris and Immobilization With Graphene Oxide-Based Fe3O4 Nanoparticles for Rapeseed Oil Degumming. Front Microbiol 2019, 10.
16 Yang, P.*; Wu, Y.; Qian, J.; Cai, K.; Cao, L; Zheng, Z.; Luo, S. ;Jiang, S.; Zhu, X., Effect of prodigiosin on the alleviation of the intestinal inflammation of weaned rats based on 1H-NMR spectroscopy study and biochemistry indexes. Brazilian Journal of Pharmaceutical Sciences 2019, 55, e17819-e17819.
17 Yang, P.*; Wu, Y.; Jiang, S.; Zheng, Z.; Hou, Z.; Mu, D.; Xiao, W.; Jiang, S.; Yang, Y., Effective Expression of the Serratia marcescens Phospholipase A1 Gene in Escherichia coli BL21(DE3), Enzyme Characterization, and Crude Rapeseed Oil Degumming via a Free Enzyme Approach. Frontiers in Bioengineering and Biotechnology 2019, 7.
18 Yang, P.*; Qian, J.; Xiao, W.; Zheng, Z.; Zhu, M., Bioactive Compound Prodigiosin in Vivo Affecting the Nutrient Metabolism of Weaned Rats. Acs Omega 2018, 3 (12), 17474-17480.
19 Yang, P.*; Zhu, X.; Zheng, Z.; Mu, D.; Jiang, S.; Luo, S.; Wu, Y.; Du, M., Cell regeneration and cyclic catalysis of engineered Kluyveromyces marxianus of a d-psicose-3-epimerase gene from Agrobacterium tumefaciens for d-allulose production. World Journal of Microbiology & Biotechnology 2018, 34 (5).
20 Yang, P.*; Wu, Y.; Zheng, Z.; Cao, L.; Zhu, X.; Mu, D.; Jiang, S., CRISPR-Cas9 Approach Constructing Cellulase sestc-Engineered Saccharomyces cerevisiae for the Production of Orange Peel Ethanol. Front Microbiol 2018, 9.
21 Yang, P.*; Zhang, H.; Zheng, Z., Glyceraldehyde-3-phosphatedehydrogenase promoter from enoki mushroom drove gene expression of exogenous cellulase in Aspergillus niger. Biomass Conversion and Biorefinery 2018, 8 (1), 11-17.
22 Mu, D.; Lu, J.; Qiao, M.; Kuipers, O.; Zhu, J.; Li, X.; Yang, P.; Zhao, Y.; Luo, S.;Wu, X.; Jiang, S.; Zheng, Z., Heterologous signal peptides-directing secretion of Streptomyces mobaraensis transglutaminase by Bacillus subtilis. Applied Microbiology and Biotechnology 2018, 102 (13), 5533-5543.
23 Mu, D.; Lu, J.; Shu, C.; Li, H.; Li, X.; Cai, J.; Luo, S.; Yang, P.; Jiang, S.; Zheng, Z., Improvement of the activity and thermostability of microbial transglutaminase by multiple-site mutagenesis. Biosci Biotech Bioch 2018, 82 (1), 106-109.
24 Yang, P.*; Zhang, H.; Cao, L.; Zheng, Z.; Mu, D.; Jiang, S.; Cheng, J., Combining sestc engineered A. niger with sestc engineered S. cerevisiae to produce rice straw ethanol via step-by-step and in situ saccharification and fermentation. 3 Biotech 2017, 8.
25 Yang, P.*; Zhu, X.; Cao, L.; Cheng, S.; Zheng, Z.; Jiang, S., Safety evaluation of Bacillus cereus isolated from smelly mandarin fish. Journal of Food Measurement and Characterization 2017, 11 (2), 726-735.
26 Yang, P.; Zhang, H.; Cao, L.; Zheng, Z.; Jiang, S. Construction of Aspergillus niger integrated with cellulase gene from Ampullaria gigas Spix for improved enzyme production and saccharification of alkaline-pretreated rice straw. 3 Biotech 2016, 6.
27 Yang, P.*; Zhang, H.; Jiang, S., Construction of recombinant sestc Saccharomyces cerevisiae for consolidated bioprocessing, cellulase characterization, and ethanol production by in situ fermentation. 3 Biotech 2016, 6.
28 Cheng, S.; Yang, P.; Guo, L.; Lin, J.; Lou, N., Expression of multi-functional cellulase gene mfc in Coprinus cinereus under control of different basidiomycete promoters. Bioresource Technology 2009, 100 (19), 4475-4480.
29 Bao, F.; Yan, H.; Sun, H.; Yang, P.; Liu, G.; Zhou, X., Hydrolysis of by-product adenosine diphosphate from 3 '-phosphoadenosine-5 '-phosphosulfate preparation using Nudix hydrolase NudJ. Applied Microbiology and Biotechnology 2015, 99 (24), 10771-10778.
30 Ke, W.; Chang, S.; Chen, X.; Luo, S.; Jiang, S.; Yang, P.; Wu, X.; Zheng, Z., Metabolic control analysis of L-lactate synthesis pathway in Rhizopus oryzae As 3.2686. Bioprocess and Biosystems Engineering 2015, 38 (11), 2189-2199.
31 Ye, M.; Wang, J; Guo, G.; He, Y.; Lu, Y.; Ye, Y..; Yang,Q.; Yang, P., Physicochemical characteristics and antioxidant activity of arginine-modified melanin from Lachnum YM-346. Food Chem 2012, 135 (4), 2490-2497.
32 Yang, P.; Guo, L.; Cheng, S.; Lou, N.; Lin, J., Recombinant multi-functional cellulase activity in submerged fermentation of lignocellulosic wastes. Renewable Energy 2011, 36 (12), 3268-3272.
中文
1 邓衍宏;汪虎;周勇;卢久灵;杨培周*, 提高乙酸耐受性酿酒酵母JJJ1突变株构建及转录组学分析, 食品安全质量检测学报,2023,.DOI, 10.19812/j.cnki.jfsq11-5956/ts.2023.11.001
2 杨培周;陆书花;李丛旭;王泽民,柠檬酸水解法制备大豆多肽的研究,农产品加工2023, ,DOI：10.16693/j.cnki.1671-9646(X).2023.05.030
3 杨培周;陆书花;杨雨翰;李丛旭;王泽民, 不同加工工艺对大豆多肽形成的影响农产品加工,2023, 10.16693/j.cnki.1671-9646(X).2023.05.010
4 周勇,杨培周,低甘油产率的酿酒酵母工程菌构建研究进展,当代化工, 2021 ,50 (04) 10.13840/j.cnki.cn21-1457/tq.2021.04.037
5朱星星,杨培周*,杜明睿,吴芸,姜绍通.根癌农杆菌D-阿洛酮糖-3-差向异构酶基因克隆、结构预测及原核表达[J].食品科学技术学报,2019,37(03):61-66
6杜明睿,杨培周*,陈新颜,操丽丽,吴芸,姜绍通,朱星星,单浩东.加工工艺对鸡酥松生产过程中美拉德反应的影响[J].食品科学技术学报,2018,36(03):72-77.
7杜明睿,杨培周*,程杰顺,柏林,操丽丽,姜绍通,单浩东.加工工艺对鸡酥松脂肪氧化的影响[J].食品科学技术学报,2019,37(01):98-103.
8杨培周*朱星星,操丽丽,郑志,程杰顺,姜绍通.传统发酵食品臭鳜鱼中分离的苏云金芽孢杆菌(Bacillus thuringiensis 29.118)的毒理学评价（英文）[J].食品科学,2019,40(03):186-193.
9杨培周*,单浩东,周良正,操丽丽,姜绍通.炒松温度对鸡酥松水分迁移及蛋白纤维结构的影响[J].肉类工业,2017(08):33-36.
10吴芸,杨培周*,操丽丽,单浩东,陈新颜,姜绍通.酥松加工的鸡胸肉品质影响因素分析[J].肉类工业,2017(03):33-35+38.
11吴芸,杨培周*,单浩东,操丽丽,陈新颜,姜绍通.酥松特征风味形成机制的研究进展[J].肉类工业,2017(02):37-40.
12钱静,杨培周*,操丽丽,操新民,郑志,姜绍通.灵菌红素对断奶大鼠肠道发育以及抗氧化能力的影响[J].食品科学,2017,38(17):244-250.
13杨培周*,周良正,操丽丽,姜绍通,郑志,单浩东.鸡肉酥松危害分析与关键控制点(HACCP)系统建立[J].肉类工业,2016(09):40-44+49.
14陈新颜,操丽丽,杨培周*,王康林,章华,操新民,郑志,姜绍通.响应面试验优化黏质沙雷氏菌利用菜籽饼粕产灵菌红素工艺[J].食品科学,2017,38(04):231-236.
15陈新颜,杨培周*,姜绍通,郑志,操丽丽,操新民,朱星星,张丹峰,刘广庆.天然红色素灵菌红素的急性经口毒性和遗传毒性[J].食品科学,2017,38(13):224-228.
16杨培周. mfc酿酒酵母基因工程菌构建及纤维素酶系特性[C]. 中国微生物学会酶工程专业委员会,2015:87-89.
17张丹峰,杨培周,姜绍通.一株分离自鳜鱼肠道的粘质沙雷氏菌(Serratia marcescens)HFUT 1301的鉴定及灵菌红素的分析[J].现代食品科技,2015,31(06):78-83+204.
18张丹峰,杨培周,操丽丽,姜绍通.粘质沙雷氏菌摇瓶发酵产灵菌红素的工艺优化[J].食品科学,2015,36(13):119-124.
19柯玮,郑志,姜绍通,罗水忠,吴学凤,杨培周,李兴江.米根霉As3.2686丙酮酸分支点代谢通量分析及相关酶活性研究[J].高校化学工程学报,2014,28(05):1071-1079.
20郭晨晨,罗水忠,杨培周,李新江,郑志.改变NADH代谢途径对米根霉酵解的影响[J].农产品加工(学刊),2014(07):50-54.
21杨培周,钱静,姜绍通,潘丽军,王建强,张丹峰,操新民.臭鳜鱼的质构特性、特征气味及发酵微生物的分离鉴定[J].现代食品科技,2014,30(04):55-62.
22高星星,潘丽军,杨培周,王秀洋.里氏木霉与黑曲霉混合发酵产纤维素酶的条件优化[J].食品科学,2012,33(19):193-198.
23杨培周,郑志,罗水忠,姜绍通,陈淼林,高书蕊.酿酒酵母和嗜鞣管囊酵母对稀酸水解抑制物的耐受性[J].农业机械学报,2012,43(04):88-92.
24郑志,李超孟,杨培周,王丽娟,李兴江,罗水忠,姜绍通.不同预处理对玉米芯酶解特性和形态结构的影响研究[J].可再生能源,2012,30(03):43-48.
25杨培周. 嗜鞣管囊酵母产乙醇的关键酶及蛋白质组双向电泳图谱分析[C]. 中国微生物学会酶工程专业委员会2011:95-97.
26袁忠娣,潘丽军,杨培周.复合诱变选育丙酮丁醇梭菌发酵玉米秸秆水解液[J].安徽农业科学,2011,39(24):14778-14781+14796.
27杨培周,郭丽琼,林俊芳.毛柄金钱菌gpd启动子驱动福寿螺纤维素酶基因在灰盖鬼伞菌中的表达[J].食品科学,2011,32(15):209-213.
28杨培周,姜绍通,郑志,罗水忠,高星星.4种工业微生物产纤维素酶酶学特性的比较研究[J].可再生能源,2011,29(04):68-71.
29潘丽军,储开庆,杨培周.嗜鞣管囊酵母木糖发酵乙醇高产突变株选育及其发酵特性[J].核农学报,2011,25(03):477-481.
30姜绍通,吴锦长,杨培周,潘丽军.纤维素酶产生菌的诱变选育及发酵条件优化[J].食品科学,2011,32(11):192-197.
31杨培周,姜绍通,郑志.组合酶催化体系产氢气的研究进展[J].农业工程学报,2011,27(S1):189-193.
32杨培周,姜绍通,郑志,罗水忠.草坪草糖化及发酵生产燃料乙醇[J].农业工程学报,2011,27(S1):143-146.
33邱静,罗水忠,姜绍通,郑志,杨培周.高产L-乳酸米根霉的原生质体制备与再生条件研究[J].食品科学,2011,32(09):174-178.
34杨培周,姜绍通,郑志,罗水忠,高星星.碱性氧化物预处理玉米秸秆维管柱、皮层和表皮研究[J].农业机械学报,2010,41(S1):137-140.
35杨培周,姜绍通,潘丽军,罗水忠,许燕,易守连.玉米芯糖化微波与酸/碱联合预处理效果实验分析[J].农业机械学报,2010,41(07):101-104.
36杨培周,姜绍通,罗水忠.枯草芽孢杆菌05表达β-甘露聚糖酶酶学性质的初步研究[J].食品与发酵工业,2010,36(01):5-7.
37杨培周,姜绍通,潘丽军,罗水忠,黄俊.超声波/稀H_2SO_4预处理对玉米秸秆液体发酵产纤维素酶的影响[J].安徽农业科学,2010,38(01):520-521+537.
38杨培周,姜绍通,潘丽军,罗水忠,黄俊.超声波/稀H_2SO_4预处理对玉米秸秆液体发酵产纤维素酶的影响(摘要)(英文)[J].Agricultural Science & Technology,2009,10(06):20-22.
39易守连,潘丽军,杨培周,高星星.玉米芯纤维素、半纤维素分离及水解成可发酵性糖初步研究[J].包装与食品机械,2009,27(06):35-40.
40杨培周,郭丽琼,王艺红,林俊芳.福寿螺(Ampullaria crossean)mfc基因的分子克隆和序列分析[J].中国食品学报,2008(04):21-27.
41杨培周,郭丽琼,王艺红,林俊芳.毛柄金钱菌gpd-Fv启动子的克隆及序列分析[J].工业微生物,2008(03):33-37.
42杨培周,刘向东,李金泉,卢永根.高州普通野生稻主要生殖性状的数理统计分析[J].植物遗传资源学报,2006(04):393-397. 43杨培周,郭海滨,赵杏娟,李金泉,刘向东,卢永根（中国科学院院士）.广东高州普通野生稻生殖特性的研究 Ⅱ.胚囊育性、胚囊发育、胚胎发生和胚乳发育[J].植物遗传资源学报,2006(02):136-143.
44杨培周,郭海滨,赵杏娟,李金泉,黄成达,刘向东,卢永根（中国科学院院士）.广东高州普通野生稻生殖特性的研究 Ⅰ.结实率、花粉育性及其发育特点[J].植物遗传资源学报,2006(01):7-12.

指导比赛获奖
1.2015年，安徽省互联网+大学生创新创业大赛，省级金奖。
2.2022年第六届安徽省互联网+大学生创新创业大赛，省级银奖。
3.2020年第六届安徽省互联网+大学生创新创业大赛，省级银奖。
4.2016 创青春，省级银奖。
5.2018年“古井贡酒·年份原浆”杯安徽省第五届工业设计大赛食品工业设计专项赛，省级三等奖。
6. 2020年第十届全国大学生电子商务“创新、创意及创业”挑战赛安徽赛，省级三等奖。
7.多次组织学生参加中国大学生茶文化创新大赛（齐源杯2019，“徽府茶行杯”2018，白云春毫杯2016年）大赛，并获奖。

职务：		职称：	副教授、硕导
所属系：	食品科学与工程系	邮箱：	yangpeizhou@163.com <br>yangpeizhou@hfut.edu.cn
办公地点：	食品楼817	学术成果	<br>1 Peizhou Yang; Zhuanzhuan Lin; Jianchao Chen; Shuying Jiang; Zhi Zheng; Kanglin Wang. S. cerevisiae ERG5DeltaNTH1DeltaAMS1Delta construction enhancing stress tolerance for ethanol production increase in the presence of inhibitors and mechanism analysis based on the comparative transcriptomics, Heliyon, 2024, e37885. in press. <br>2 Wu, Wenjing; Lu, Shuhua; Jiang, Suwei; Chen, Jianchao; Zheng, Zhi; Jiang, Shaotong; Yang, Peizhou. Immobilization of recombinant Trametes versicolor aflatoxin B1-degrading enzyme (TV-AFB1D) with montmorillonite for absorption and in situ degradation of aflatoxin B1. Mycotoxin Research, 2024. DOI10.1007/s12550-024-00520-x. <br>3 Peizhou Yang; Jianchao Chen; Wenjing Wu; Suwei Jiang; Yanhong Deng; Jiuling Lu; Hu Wang; Yong Zhou; Yuyou Geng; Zhi Zheng. Saccharomyces cerevisiae MET5DeltaSIZ1Delta enhancing organic acid tolerance with XYL1 and XYL2 integration for ethanol yield improvement in the presence of xylose and low pH value. LWT - Food Science and Technology 180 (2023) 114718. <br>4 Peizhou Yang; Wenjing Wu; Jianchao Chen; Suwei Jiang; Zhi Zheng; Yanhong Deng; Jiuling Lu; Hu Wang; Yong Zhou; Yuyou Geng; Kanglin Wang. Thermotolerance improvement of engineered Saccharomyces cerevisiae ERG5 Delta ERG4 Delta ERG3 Delta, molecular mechanism, and its application in corn ethanol production. Biotechnology for Biofuels and Bioproducts (2023) 16:66. <br>5 Yang, Peizhou; Wu, Wenjing; Zhang, Danfeng; Cao, Lili; Cheng, Jieshun. AFB1 Microbial Degradation by Bacillus subtilis WJ6 and Its Degradation Mechanism Exploration Based on the Comparative Transcriptomics Approach. Metabolites,2023, 13(7). DOI10.3390/metabo13070785. <br>6 Yang, Peizhou; Jiang, Shuying; Lu, Shuhua; Jiang, Suwei; Jiang, Shaotong; Deng, Yanhong; Lu, Jiuling; Wang, Hu; Zhou, Yong. Ethanol yield improvement in Saccharomyces cerevisiae GPD2 Delta FPS1 Delta ADH2 Delta DLD3 Delta mutant and molecular mechanism exploration based on the metabolic flux and transcriptomics approaches, Microbial Cell Factories 2022,21(1):160. <br>7 Yang, Peizhou; Jiang, Shuying; Jiang, Suwei; Lu, Shuhua; Zheng, Zhi; Chen, Jianchao; Wu, Wenjing; Jiang, Shaotong. CRISPR-Cas9 Approach Constructed Engineered Saccharomyces cerevisiae with the Deletion of GPD2, FPS1, and ADH2 to Enhance the Production of Ethanol, Journal of Fungi, 2022,8(7):703. <br>8 Peizhou Yang; Wei Xiao;, Shuhua Lu; Shuying Jiang; Suwei Jiang; Jianchao Chen; Wenjing Wu; Zhi Zheng; Shaotong Jiang. Characterization of a Trametes versicolor aflatoxin B1-degrading enzyme (TV-AFB1D) and its application in the AFB1 degradation of contaminated rice in situ,Front. Microbiol.2022, 13:960882. doi: 10.3389/fmicb.2022.960882. <br>9 Yang, Peizhou; Xiao, Wei; Lu, Shuhua; Jiang, Suwei; Zheng, Zhi; Zhang, Danfeng; Zhang, Min; Jiang, Shaotong; Jiang, Shuying. Recombinant Expression of Trametes versicolor Aflatoxin B1-Degrading Enzyme (TV-AFB1D) in Engineering Pichia pastoris GS115 and Application in AFB1 Degradation in AFB1-Contaminated Peanuts. Toxins (Basel), 2021. 13(5). <br>10 Yang, Peizhou; Lu, Shuhua; Xiao, Wei; Zheng, Zhi; Jiang, Suwei; Jiang, Shaotong; Jiang, Shuying; Cheng, Jieshun; Zhang, Danfeng. Activity enhancement of Trametes versicolor aflatoxin B-1-degrading enzyme (TV-AFB(1)D) by molecular docking and site-directed mutagenesis. Food and Bioproducts Processing, 2021. 129: 168-175. <br>11 Zhang, H.; Zhai, C.; Yang, P.; Yuan, C.; Fu, N.; Zhu, M., In Situ Growth of BiOI/MoS2 Heterostructure as Pt Supports for Visible Light-Assisted Electrocatalytic Methanol Oxidation Reaction. Energy Technology 2020, 8 (1). <br>12 Yang, P.; Du, M.; Cao, L.; Yu, Z.; Jiang, S., Preparation and Characterization of Emulsion-based Peony Seed Oil Microcapsule. Journal of oleo science 2020, 69 (3), 219-226. <br>13 Jiang, S.; Xiao, W.; Zhu, X.; Yang, P.; Zheng, Z.; Lu, S.; Jiang, S.; Zhang, G; .Liu, J., Review on D-Allulose: In vivo Metabolism, Catalytic Mechanism, Engineering Strain Construction, Bio-Production Technology. Frontiers in Bioengineering and Biotechnology 2020, 8. <br>14 Mu, D.; Li, H.; Li, X.; Zhu, J.; Qiao, M.; Wu, X.; Luo, S.; Yang, P.; Zhao, Y.; Liu, F.; Jiang, S.; Zheng, Z., Enhancing laccase-induced soybean protein isolates gel properties by microwave pretreatment. Journal of Food Processing and Preservation 2020. <br>15 Yang, P.; Jiang, S.; Wu,Y.; Hou, Z.; Zheng, Z.; Cao, L.; Du,M.; Jiang,S. Recombinant Expression of Serratia marcescens Outer Membrane Phospholipase A (A1) in Pichia pastoris and Immobilization With Graphene Oxide-Based Fe3O4 Nanoparticles for Rapeseed Oil Degumming. Front Microbiol 2019, 10. <br>16 Yang, P.; Wu, Y.; Qian, J.; Cai, K.; Cao, L; Zheng, Z.; Luo, S. ;Jiang, S.; Zhu, X., Effect of prodigiosin on the alleviation of the intestinal inflammation of weaned rats based on 1H-NMR spectroscopy study and biochemistry indexes. Brazilian Journal of Pharmaceutical Sciences 2019, 55, e17819-e17819. <br>17 Yang, P.; Wu, Y.; Jiang, S.; Zheng, Z.; Hou, Z.; Mu, D.; Xiao, W.; Jiang, S.; Yang, Y., Effective Expression of the Serratia marcescens Phospholipase A1 Gene in Escherichia coli BL21(DE3), Enzyme Characterization, and Crude Rapeseed Oil Degumming via a Free Enzyme Approach. Frontiers in Bioengineering and Biotechnology 2019, 7. <br>18 Yang, P.; Qian, J.; Xiao, W.; Zheng, Z.; Zhu, M., Bioactive Compound Prodigiosin in Vivo Affecting the Nutrient Metabolism of Weaned Rats. Acs Omega 2018, 3 (12), 17474-17480. <br>19 Yang, P.; Zhu, X.; Zheng, Z.; Mu, D.; Jiang, S.; Luo, S.; Wu, Y.; Du, M., Cell regeneration and cyclic catalysis of engineered Kluyveromyces marxianus of a d-psicose-3-epimerase gene from Agrobacterium tumefaciens for d-allulose production. World Journal of Microbiology & Biotechnology 2018, 34 (5). <br>20 Yang, P.; Wu, Y.; Zheng, Z.; Cao, L.; Zhu, X.; Mu, D.; Jiang, S., CRISPR-Cas9 Approach Constructing Cellulase sestc-Engineered Saccharomyces cerevisiae for the Production of Orange Peel Ethanol. Front Microbiol 2018, 9. <br>21 Yang, P.; Zhang, H.; Zheng, Z., Glyceraldehyde-3-phosphatedehydrogenase promoter from enoki mushroom drove gene expression of exogenous cellulase in Aspergillus niger. Biomass Conversion and Biorefinery 2018, 8 (1), 11-17. <br>22 Mu, D.; Lu, J.; Qiao, M.; Kuipers, O.; Zhu, J.; Li, X.; Yang, P.; Zhao, Y.; Luo, S.;Wu, X.; Jiang, S.; Zheng, Z., Heterologous signal peptides-directing secretion of Streptomyces mobaraensis transglutaminase by Bacillus subtilis. Applied Microbiology and Biotechnology 2018, 102 (13), 5533-5543. <br>23 Mu, D.; Lu, J.; Shu, C.; Li, H.; Li, X.; Cai, J.; Luo, S.; Yang, P.; Jiang, S.; Zheng, Z., Improvement of the activity and thermostability of microbial transglutaminase by multiple-site mutagenesis. Biosci Biotech Bioch 2018, 82 (1), 106-109. <br>24 Yang, P.; Zhang, H.; Cao, L.; Zheng, Z.; Mu, D.; Jiang, S.; Cheng, J., Combining sestc engineered A. niger with sestc engineered S. cerevisiae to produce rice straw ethanol via step-by-step and in situ saccharification and fermentation. 3 Biotech 2017, 8. <br>25 Yang, P.; Zhu, X.; Cao, L.; Cheng, S.; Zheng, Z.; Jiang, S., Safety evaluation of Bacillus cereus isolated from smelly mandarin fish. Journal of Food Measurement and Characterization 2017, 11 (2), 726-735. <br>26 Yang, P.; Zhang, H.; Cao, L.; Zheng, Z.; Jiang, S. Construction of Aspergillus niger integrated with cellulase gene from Ampullaria gigas Spix for improved enzyme production and saccharification of alkaline-pretreated rice straw. 3 Biotech 2016, 6. <br>27 Yang, P.; Zhang, H.; Jiang, S., Construction of recombinant sestc Saccharomyces cerevisiae for consolidated bioprocessing, cellulase characterization, and ethanol production by in situ fermentation. 3 Biotech 2016, 6. <br>28 Cheng, S.; Yang, P.; Guo, L.; Lin, J.; Lou, N., Expression of multi-functional cellulase gene mfc in Coprinus cinereus under control of different basidiomycete promoters. Bioresource Technology 2009, 100 (19), 4475-4480. <br>29 Bao, F.; Yan, H.; Sun, H.; Yang, P.; Liu, G.; Zhou, X., Hydrolysis of by-product adenosine diphosphate from 3 '-phosphoadenosine-5 '-phosphosulfate preparation using Nudix hydrolase NudJ. Applied Microbiology and Biotechnology 2015, 99 (24), 10771-10778. <br>30 Ke, W.; Chang, S.; Chen, X.; Luo, S.; Jiang, S.; Yang, P.; Wu, X.; Zheng, Z., Metabolic control analysis of L-lactate synthesis pathway in Rhizopus oryzae As 3.2686. Bioprocess and Biosystems Engineering 2015, 38 (11), 2189-2199. <br>31 Ye, M.; Wang, J; Guo, G.; He, Y.; Lu, Y.; Ye, Y..; Yang,Q.; Yang, P., Physicochemical characteristics and antioxidant activity of arginine-modified melanin from Lachnum YM-346. Food Chem 2012, 135 (4), 2490-2497. <br>32 Yang, P.; Guo, L.; Cheng, S.; Lou, N.; Lin, J., Recombinant multi-functional cellulase activity in submerged fermentation of lignocellulosic wastes. Renewable Energy 2011, 36 (12), 3268-3272. <br>中文 <br>1 邓衍宏;汪虎;周勇;卢久灵;杨培周, 提高乙酸耐受性酿酒酵母JJJ1突变株构建及转录组学分析, 食品安全质量检测学报,2023,.DOI, 10.19812/j.cnki.jfsq11-5956/ts.2023.11.001 <br>2 杨培周;陆书花;李丛旭;王泽民,柠檬酸水解法制备大豆多肽的研究,农产品加工2023, ,DOI：10.16693/j.cnki.1671-9646(X).2023.05.030 <br>3 杨培周;陆书花;杨雨翰;李丛旭;王泽民, 不同加工工艺对大豆多肽形成的影响农产品加工,2023, 10.16693/j.cnki.1671-9646(X).2023.05.010 <br>4 周勇,杨培周,低甘油产率的酿酒酵母工程菌构建研究进展,当代化工, 2021 ,50 (04) 10.13840/j.cnki.cn21-1457/tq.2021.04.037 <br>5朱星星,杨培周,杜明睿,吴芸,姜绍通.根癌农杆菌D-阿洛酮糖-3-差向异构酶基因克隆、结构预测及原核表达[J].食品科学技术学报,2019,37(03):61-66 <br>6杜明睿,杨培周,陈新颜,操丽丽,吴芸,姜绍通,朱星星,单浩东.加工工艺对鸡酥松生产过程中美拉德反应的影响[J].食品科学技术学报,2018,36(03):72-77. <br>7杜明睿,杨培周,程杰顺,柏林,操丽丽,姜绍通,单浩东.加工工艺对鸡酥松脂肪氧化的影响[J].食品科学技术学报,2019,37(01):98-103. <br>8杨培周朱星星,操丽丽,郑志,程杰顺,姜绍通.传统发酵食品臭鳜鱼中分离的苏云金芽孢杆菌(Bacillus thuringiensis 29.118)的毒理学评价（英文）[J].食品科学,2019,40(03):186-193. <br>9杨培周,单浩东,周良正,操丽丽,姜绍通.炒松温度对鸡酥松水分迁移及蛋白纤维结构的影响[J].肉类工业,2017(08):33-36. <br>10吴芸,杨培周,操丽丽,单浩东,陈新颜,姜绍通.酥松加工的鸡胸肉品质影响因素分析[J].肉类工业,2017(03):33-35+38. <br>11吴芸,杨培周,单浩东,操丽丽,陈新颜,姜绍通.酥松特征风味形成机制的研究进展[J].肉类工业,2017(02):37-40. <br>12钱静,杨培周,操丽丽,操新民,郑志,姜绍通.灵菌红素对断奶大鼠肠道发育以及抗氧化能力的影响[J].食品科学,2017,38(17):244-250. <br>13杨培周,周良正,操丽丽,姜绍通,郑志,单浩东.鸡肉酥松危害分析与关键控制点(HACCP)系统建立[J].肉类工业,2016(09):40-44+49. <br>14陈新颜,操丽丽,杨培周,王康林,章华,操新民,郑志,姜绍通.响应面试验优化黏质沙雷氏菌利用菜籽饼粕产灵菌红素工艺[J].食品科学,2017,38(04):231-236. <br>15陈新颜,杨培周*,姜绍通,郑志,操丽丽,操新民,朱星星,张丹峰,刘广庆.天然红色素灵菌红素的急性经口毒性和遗传毒性[J].食品科学,2017,38(13):224-228. <br>16杨培周. mfc酿酒酵母基因工程菌构建及纤维素酶系特性[C]. 中国微生物学会酶工程专业委员会,2015:87-89. <br>17张丹峰,杨培周,姜绍通.一株分离自鳜鱼肠道的粘质沙雷氏菌(Serratia marcescens)HFUT 1301的鉴定及灵菌红素的分析[J].现代食品科技,2015,31(06):78-83+204. <br>18张丹峰,杨培周,操丽丽,姜绍通.粘质沙雷氏菌摇瓶发酵产灵菌红素的工艺优化[J].食品科学,2015,36(13):119-124. <br>19柯玮,郑志,姜绍通,罗水忠,吴学凤,杨培周,李兴江.米根霉As3.2686丙酮酸分支点代谢通量分析及相关酶活性研究[J].高校化学工程学报,2014,28(05):1071-1079. <br>20郭晨晨,罗水忠,杨培周,李新江,郑志.改变NADH代谢途径对米根霉酵解的影响[J].农产品加工(学刊),2014(07):50-54. <br>21杨培周,钱静,姜绍通,潘丽军,王建强,张丹峰,操新民.臭鳜鱼的质构特性、特征气味及发酵微生物的分离鉴定[J].现代食品科技,2014,30(04):55-62. <br>22高星星,潘丽军,杨培周,王秀洋.里氏木霉与黑曲霉混合发酵产纤维素酶的条件优化[J].食品科学,2012,33(19):193-198. <br>23杨培周,郑志,罗水忠,姜绍通,陈淼林,高书蕊.酿酒酵母和嗜鞣管囊酵母对稀酸水解抑制物的耐受性[J].农业机械学报,2012,43(04):88-92. <br>24郑志,李超孟,杨培周,王丽娟,李兴江,罗水忠,姜绍通.不同预处理对玉米芯酶解特性和形态结构的影响研究[J].可再生能源,2012,30(03):43-48. <br>25杨培周. 嗜鞣管囊酵母产乙醇的关键酶及蛋白质组双向电泳图谱分析[C]. 中国微生物学会酶工程专业委员会2011:95-97. <br>26袁忠娣,潘丽军,杨培周.复合诱变选育丙酮丁醇梭菌发酵玉米秸秆水解液[J].安徽农业科学,2011,39(24):14778-14781+14796. <br>27杨培周,郭丽琼,林俊芳.毛柄金钱菌gpd启动子驱动福寿螺纤维素酶基因在灰盖鬼伞菌中的表达[J].食品科学,2011,32(15):209-213. <br>28杨培周,姜绍通,郑志,罗水忠,高星星.4种工业微生物产纤维素酶酶学特性的比较研究[J].可再生能源,2011,29(04):68-71. <br>29潘丽军,储开庆,杨培周.嗜鞣管囊酵母木糖发酵乙醇高产突变株选育及其发酵特性[J].核农学报,2011,25(03):477-481. <br>30姜绍通,吴锦长,杨培周,潘丽军.纤维素酶产生菌的诱变选育及发酵条件优化[J].食品科学,2011,32(11):192-197. <br>31杨培周,姜绍通,郑志.组合酶催化体系产氢气的研究进展[J].农业工程学报,2011,27(S1):189-193. <br>32杨培周,姜绍通,郑志,罗水忠.草坪草糖化及发酵生产燃料乙醇[J].农业工程学报,2011,27(S1):143-146. <br>33邱静,罗水忠,姜绍通,郑志,杨培周.高产L-乳酸米根霉的原生质体制备与再生条件研究[J].食品科学,2011,32(09):174-178. <br>34杨培周,姜绍通,郑志,罗水忠,高星星.碱性氧化物预处理玉米秸秆维管柱、皮层和表皮研究[J].农业机械学报,2010,41(S1):137-140. <br>35杨培周,姜绍通,潘丽军,罗水忠,许燕,易守连.玉米芯糖化微波与酸/碱联合预处理效果实验分析[J].农业机械学报,2010,41(07):101-104. <br>36杨培周,姜绍通,罗水忠.枯草芽孢杆菌05表达β-甘露聚糖酶酶学性质的初步研究[J].食品与发酵工业,2010,36(01):5-7. <br>37杨培周,姜绍通,潘丽军,罗水忠,黄俊.超声波/稀H_2SO_4预处理对玉米秸秆液体发酵产纤维素酶的影响[J].安徽农业科学,2010,38(01):520-521+537. <br>38杨培周,姜绍通,潘丽军,罗水忠,黄俊.超声波/稀H_2SO_4预处理对玉米秸秆液体发酵产纤维素酶的影响(摘要)(英文)[J].Agricultural Science & Technology,2009,10(06):20-22. <br>39易守连,潘丽军,杨培周,高星星.玉米芯纤维素、半纤维素分离及水解成可发酵性糖初步研究[J].包装与食品机械,2009,27(06):35-40. <br>40杨培周,郭丽琼,王艺红,林俊芳.福寿螺(Ampullaria crossean)mfc基因的分子克隆和序列分析[J].中国食品学报,2008(04):21-27. <br>41杨培周,郭丽琼,王艺红,林俊芳.毛柄金钱菌gpd-Fv启动子的克隆及序列分析[J].工业微生物,2008(03):33-37. <br>42杨培周,刘向东,李金泉,卢永根.高州普通野生稻主要生殖性状的数理统计分析[J].植物遗传资源学报,2006(04):393-397. 43杨培周,郭海滨,赵杏娟,李金泉,刘向东,卢永根（中国科学院院士）.广东高州普通野生稻生殖特性的研究 Ⅱ.胚囊育性、胚囊发育、胚胎发生和胚乳发育[J].植物遗传资源学报,2006(02):136-143. <br>44杨培周,郭海滨,赵杏娟,李金泉,黄成达,刘向东,卢永根（中国科学院院士）.广东高州普通野生稻生殖特性的研究 Ⅰ.结实率、花粉育性及其发育特点[J].植物遗传资源学报,2006(01):7-12.
研究领域	<br>1.基因编辑技术和合成生物学 <br>基于基因编辑的酵母工程菌改造，提高乙醇产率、耐胁迫能力，增加底物的利用率；采用代谢工程和系统生物学原理，改造微生物代谢路径提高NAD及辅酶A等高附加值辅因子的表达和积累；改造菌种代谢路径提高微生物氨基酸积累和表达。 <br>2.食品酶工程和益生菌开发 <br>适应于黄曲霉毒素、呕吐毒素和玉米赤霉烯酮等生物毒素降解新酶的开发和创制；采用机器学习和分子对接等方法设计和创制新型人工酶；开发适用于饲料和食品的功能性益生菌，包括酵母、乳酸菌和枯草芽孢杆菌等。	科研项目	<br>1.粮食淀粉质生物发酵及分子筛膜制备高纯电子级乙醇的关键技术研发及产业化（202003c08020001），安徽省科技重大专项—重大科技成果工程化研发项目，主持。 <br>2.蛋白基豆制品酶法高值化加工技术集成熟化及示范推广（202103b06020014），安徽省科技重大专项，主持。 <br>3.酥松加工关键技术及质量控制体系研究（1604a0702001），安徽省科技攻关计划项目，主持。 <br>4.云芝黄曲霉毒素解毒酶的酵母基因工程菌构建及解毒机制研究（1908085MC80），安徽省自然科学基金面上，主持。 <br>5.高表达多功能纤维素酶基因的黑曲霉基因工程菌构建（1408085MC67），安徽省自然科学基金面上，主持。 <br>6.基于基因编辑技术产高纯乙醇酿酒酵母的分子改造及碳架物质流调动机制研究（2022047），合肥市自然科学基金，主持。 <br>7.粮食真菌毒素检测及质量控制关键技术研究（PA2020GDSK0058），合肥工业大学安徽省农产品精深加工重点实验室自主创新专项，校内主持。 <br>8.茶道与茶艺（2020mooc398），安徽省省级质量工程，主持。 <br>9.广东省省部产学研合作专项资金 (2012B091100377)，主持。 <br>10.体外无细胞酶级联催化产氢研究（20100470825），中国博士后基金，主持。 <br>11.潮州市芡实蛋白肽螯合钙高效制备关键技术及产业化示范（2013B011301002），潮州市科技计划项目，主持。 <br>12.蜂蜜功能食品的研制（W2019JSKF0034），横向，主持。 <br>13.微生物辅助发酵的臭鳜鱼生产技术研发（W2015JSKF0076），横向，主持。 <br>14.大豆全果仁植物蛋白饮品生产关键技术研究及产业化（W2020JSKF0691），横向，主持。 <br>15.小麦面粉抗老化酶制剂开发及应用（W2019JSKF0681），横向，主持。
荣誉奖项	<br>指导比赛获奖 <br>1.2015年，安徽省互联网+大学生创新创业大赛，省级金奖。 <br>2.2022年第六届安徽省互联网+大学生创新创业大赛，省级银奖。 <br>3.2020年第六届安徽省互联网+大学生创新创业大赛，省级银奖。 <br>4.2016 创青春，省级银奖。 <br>5.2018年“古井贡酒·年份原浆”杯安徽省第五届工业设计大赛食品工业设计专项赛，省级三等奖。 <br>6. 2020年第十届全国大学生电子商务“创新、创意及创业”挑战赛安徽赛，省级三等奖。 <br>7.多次组织学生参加中国大学生茶文化创新大赛（齐源杯2019，“徽府茶行杯”2018，白云春毫杯2016年）大赛，并获奖。

食品科学与工程系