Xiaoni Ai
Associate Professor, Ph.D.
School of Pharmaceutical Sciences, Peking University
National Outstanding Young Scientist (2025)
Email：aixn@pku.edu.cn
We are recruiting research assistants, postdoctoral researchers and doctoral candidates. Welcome to join us!
Education
· 2004-2008, College of Chemistry and Molecular Sciences, Wuhan University, B.S.
· 2008-2013, Department of Chemistry, Tsinghua University, Ph.D.
· 2011-2013, Biomedical Engineering, Georgia Institute of Technology, Joint Ph.D.
Professional Experience
· 2013-2021, Assistant Professor, School of Pharmaceutical Sciences, Peking University
· 2021-present, Associate Professor, School of Pharmaceutical Sciences, Peking University
Research Interests
· Organs-on-Chips and Organoids-on-Chips
· Pharmaceutical Analysis for Natural Products
Selected Publications
1. Zhao Gao, Zhiyong Du, Yu Hou, Kun Hua, Pengfei Tu, Xiaoni Ai*, Yong Jiang*. A microfluidic coculture model for mapping signaling perturbations and precise drug screening against macrophage-mediated dynamic myocardial injury. Acta Pharm Sin B, 2024, 12: 5393.
2. Yu Hou, Zhao Gao, Pengfei Tu, Xiaoni Ai*, Yong Jiang*. Establishment of an Idiosyncratic Drug-Induced Liver Injury Model on a Stacked Array Chip for Identification of CCL5-Mediated Paracrine Dynamics. Analytical Chemistry, 2024, 96(49): 19370-19377.
3. Rong-Rong Xiao, Bolin Jing, Lei Yan, Jiajia Li, Pengfei Tu*, Xiaoni Ai*. Constant-rate perfused array chip for high-throughput screening of drug permeability through brain endothelium. Lab on a Chip, 2022, 22(23): 4481-4492
4. Yancheng Cui, Rongrong Xiao, Yushi Zhou, Jianchuang Liu, Yi Wang, Xiaodong Yang, Zhanlong Shen, Bin Liang, Kai Shen, Yi Li, Geng Xiong, Yingjiang Ye, Xiaoni Ai*. Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy. Bio-Design and Manufacturing, 2022, 674–686.
5. Rong-Rong Xiao, Tian Lv, Xia Tu, Peiwen Li, Tiantian Wang, Haiheng Dong, Pengfei Tu, Xiaoni Ai*. An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. Biotechnology and Bioengineering, 2021, 118(12):4687-4698.
6. Xiaoni Ai, Yang Wu, Wenbo Lu, Xinran Zhang, Lin Zhao, Pengfei Tu*, Kewei Wang*, Yong Jiang*. A Precise Microfluidic Assay in Single-Cell Profile for Screening of Transient Receptor Potential Channel Modulators. Advanced Science, 2020, 7: 2000111.
7. Xiaoni Ai, Lin Zhao, Yingyuan Lu, Yu Hou, Tian Lv, Pengfei Tu*, Xiaoyu Guo*. Integrated Array Chip for High-Throughput Screening of Species Differences in Metabolism. Analytical Chemistry, 2020, 92(17):11696-11704.
8. Yu Hou#, Xiaoni Ai#, Zhao Lin, Zhao Gao, Yujiang Wang, Yingyuan Lu, Pengfei Tu, Yong Jiang*. An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening. Lab on a Chip, 2020, 20(14):2482-2494. (Co-first authors)
9. Xiaoni Ai, Wenbo Lu, Kewu Zeng, Chun Li, Yong Jiang*, Pengfei Tu*. Microfluidic Coculture Device for Monitoring of Inflammation-Induced Myocardial Injury Dynamics. Analytical Chemistry, 2018, 90(7): 4485-4494.
10. Xiaoni Ai, Weipeng Zhuo, Qionglin Liang*, Patrick T McGrath*, Hang Lu*. A high-throughput device for size based separation of C. elegans developmental stages. Lab on a Chip, 2014, 14: 1746-1752.
11. Xiaoni Ai, Qionglin Liang, Minna Luo, Kai Zhang, Junmin Pan*, Guoan Luo*. Controlling gas/liquid exchange using microfluidics for real-time monitoring of flagellar length in living Chlamydomonas at the single-cell level. Lab on a Chip, 2012, 12: 4516-4522.
